[Spread of methicillin-resistant Staphylococcus aureus. Are our hygienic precautions sufficient?]. / Spredning af meticillinresistente staphylococcus aureus. Er vores hygiejniske forholdsregler tilstraekkelige?

A patient was transferred from Pakistan to a Danish orthopaedic ward. In Denmark he was tested MRSA-positive. Two months after he was discharged, similar MRSA strains were found in another patient. The two patients had been on the same ward for one week. All hygienic precautions had been taken. Staff and other patients on the ward at the relevant time all tested MRSA-negative.

A 6-month prospective study of hospital-acquired bacteremia in Copenhagen county.

During a 6-month period, 892 positive blood cultures were detected in the Copenhagen County hospitals. 302 (34%) were regarded as contaminations, and of the remaining cases 419 (71%) were community-acquired and 171 (29%) hospital-acquired, giving incidence rates of 6.8/1,000 admissions and 2.8/1,000 admissions, respectively. Both frequency and rate of hospital-acquired bacteremia were lower compared to most other studies. E. coli was more commonly found in community-acquired infections, while coagulase-negative staphylococci were the organisms most often considered as a contaminant. The main causative organisms in hospital-acquired infections were S. aureus (n = 37) and E. coli (n = 34). The proportion of polymicrobial bacteremias in this study was lower compared to most other studies (8%). E. coli from hospital-acquired infections were resistant to ampicillin in 42% of cases, but other Enterobacteriaceae showed higher percentage of resistance to beta-lactam antibiotics. S. aureus was penicillin-resistant in 92% of cases, but no methicillin-resistant strains were isolated. The frequency of antibiotic resistance was low compared to reports from other countries. A total of 136 hospital-acquired cases were followed prospectively. 61% of the patients were male and 46% were > or = 60 years of age. Most patients had predisposing diseases, 90% had foreign body and/or recent surgery performed, and 74 (54%) had an intraveneous catheter. The portal of entry was known in 132 (97%) of the cases, the most common being the urinary tract (42%), followed by an intravenous catheter (30%). The prevalence of urinary tract catheters gave an increased number of cases with E. coli bacteremia. The mortality was 16%.

[Clodronate in treatment of tumor osteopathy. Evaluation in tumor patients with bone metastases or hypercalcemia]. / Clodronat in der Behandlung der Tumorosteopathie. Anwendungsbeobachtung bei Tumorpatienten mit Knochenmetastasen oder Hyperkalzämien.

METHOD: In an observational study involving 398 tumor patients with bone metastases or related hypercalcemia, the effect of treatment with clodronate over a period of 12 months was investigated. Bone pain, analgesic requirements, quality of life and laboratory parameters were recorded at monthly intervals. RESULTS: Some 71.4% of all patients indicated an improvement in quality of life. Bone pain, experienced by 91.4% of the patients at the start of treatment, regressed (from 2.0 +/- 1.2 to 1.3 +/- 1.0). After the 12-month treatment period, 36% of the patients did without analgesics completely (prior to treatment the corresponding figure was 24%). The most common side effects attributed to clodronate were gastrointestinal disorders (10%). CONCLUSION: Clodronate would appear to be a useful supportive drug in the management of tumor-related bone disease.

Wound infection after cesarean section.

A prospective multicenter study of 1,032 cesarean sections was performed to identify risk factors for postoperative wound infection. The overall rate of wound infection was 6.6% (3.8% in elective cases and 7.5% following nonelective operations), with considerable interhospital variation. Obesity was recognized as a patient-related risk factor, while risk factors inherent to the obstetric situation were duration of ruptured membranes prior to operation, fetal and labor monitoring by intrauterine devices, and omission of the use of plastic draping and redisinfection of the skin before closure. Logistic regression analysis was used to estimate the influence of these factors on the probability of wound infection. Certain risk factors associated with and over-represented in nonelective operations would explain the increased infection rates in these, and the observed interhospital variations did not differ from the expected rates when the distribution of other risk factors was considered.