[Place of biochemical markers of bone turnover in guidelines for diagnosis and treatment of osteoporosis]. / Miejsce biochemicznych markerów obrotu kostnego w zaleceniach diagnostyczno-leczniczych osteoporozy.

Biochemical markers of bone turnover ara fragments of protein elements of sceleton (or product of their degradation) or enzymes and proteins release into circulation during metabolic activity cells of osteogenesis--osteoblasts and cells of osteoclastic--osteoclasts. Their concentrations at plasma and urine give us information about all metabolic processes take place presently into whole sceletal system. Measuring of concentration biochemical markers of bone turnover let us evaluate the speed of osteogenesis and osteoclastic. In this way we can predict the fractures and the changes of bone mass which will come from treatment. At polish guidelines for diagnosis and treatment of osteoporosis allowing for measuring concentration some biochemical markers of bone turnover in prediction individual 10 years risk of the fracture at postmenopausal women and in prediction the effectiveness of the treatment of osteoporosis after short time (3 months). The aim of this paper is to present the current state of knowledge on the biochemical markers of bone turnover and their place at diagnosis and treatment of osteoporosis.

[Diagnostic and prognostic significance of homocysteine determined in acute phase of myocardial infarction]. / Znaczenie rozpoznawczo-prognostyczne homocysteiny oznaczanej w ostrej fazie zawalu.

THE AIM: Of this study was to assess the serum homocysteine concentration in subjects with acute myocardial infarction and its correlation with the course of infarction and further prognosis considering particularly left ventricle dysfunction, heart rate and conduction disorders as well as to assess the usefulness of metionin load test as a prognostic test in patients with myocardial infarction. MATERIAL AND METHODS: 66 patients were studied: 36 with recent myocardial infarction and 30 healthy individuals as a control group. Fasting serum homocysteine and its concentration two hours after metionin load were determined in all patients. They all underwent echocardiographic examination, stress test and 24-hour Holter monitoring. The study revealed a significant positive correlation between increased serum homocysteine concentration in patients with myocardial infarction and worsening of contractility parameters, extent of infarction area, and negative correlation between homocysteine concentration and ejection fraction. CONCLUSIONS: On the basis of the study outcome we can make a statement that increased homocysteine concentration in patients with acute phase of myocardial infarction indicates its more severe course, more extensive disorders of myocardium kinetics, more significant left ventricle diastolic and systolic dysfunction. Increased serum homocysteine in metionin load test indicates higher death risk in patients with myocardial infarction.