Utility of respiratory-gated small-animal PET/CT in the chronologic evaluation of an orthotopic lung cancer transplantation mouse model.

Our aim in this study was to clarify the effects of respiratory-gated PET in the evaluation of lung cancer according to the (18)F-FDG uptake in an orthotopic transplantation mouse model. We created such a model, and we performed PET/CT. The mice were divided into two groups according to tumor volume: a small-tumor group (<20 mm(3)) and a large-tumor group (>20 mm(3)). We reconstructed the following conditions based on list-mode data: non-gated (3D) images and gated (4D) images, divided based on the respiratory cycle (expiration phase, stable phase, and inspiration phase). We calculated the maximum standardized uptake values (SUVmax) in each phase. We used the % difference [= (4D SUVmax - 3D SUVmax)/3D PET SUVmax × 100 (%)] to evaluate the differences in the 4D SUVmax and 3D SUVmax. The 4D SUVmax values were significantly higher than the 3D SUVmax, regardless of the tumor size. The % difference for the small tumors was greater than that for the large tumors, and it was highest in the stable phase. We conclude that the SUVmax in the stable phase under respiratory-gated PET are the most reliable. The SUVmax observed under non-gated PET are considered to be more frequently underestimated in cases involving small tumors than in those involving large tumors. In the chronologic study evaluating the time course of tumor development, the size of the tumor is small in early stage, and respiratory-gated PET is effective in reducing the underestimation of such tumors caused by respiratory motion.

[Fabrication of a visualization equipment for scattered X-rays in the diagnosis domain and proposal of a practical training].

We have built equipment that can visualize the angle distributions of scattered X-rays. The main body of the equipment is made of a lead-shielded box 340 mm long, 300 mm wide and 270 mm high. The collimated X-rays are introduced into the equipment from the front face, then scattered by the sample located in the center of the equipment. The X-rays scattering toward the upper side are detected by the phosphor plate. To verify the usability of the equipment, an experiment using diagnostic X-rays was carried out. X-rays with a tube voltage of 100 kV were narrowed down to 6 mm(phi) and a 2 mm-thick acrylic sample was irradiated. The experimental conditions with a tube current-time product of 300 mAs to 1500 mAs proved appropriate for obtaining suitable images on a 10 inch x 12 inch phosphor plate. The obtained images were analyzed using ImageJ. The experimental values were in good agreement with the theoretical distribution calculated by Klein and Nishina. Because the distribution of the scattered X-rays can be visualized in relatively simple experiments using the developed equipment, it is hoped that it will be of use for the practical training of beginners.