[Boceprevir: new possibilities for antiviral treatment of chronic hepatitis C].

The given clinical review covers current antiviral therapy for chronic hepatitis C. Traditional antiviral therapy with pegylated interferon-alpha and ribavirin in patients with chronic hepatitis C virus genotype 1 allows a sustained virological response (SVR) to be achieved in no more than 40% of the treated patients. The practical introduction of the third component of the therapy as direct-acting antiviral agents makes it possible to substantially increase SVR, on the one hand, and to reduce treatment time, on the other hand. This review carefully analyzes the results of clinical trials of boceprevir (a new direct-acting antiviral agent and an NS3 serine protease inhibitor) that, when incorporated into an antiviral therapy regimen with pegylated interferons and ribavirin, considerably improves treatment results in patients with chronic hepatitis C virus genotype 1. Also, it discusses the safety and tolerance of drugs that belong to the class of hepatitis C virus serine protease inhibitors, as well as the problem of viral resistance.

[Therapeutic response to alpha-interferon in chronic alcoholics with viral hepatitis C]. / Rezul'taty lecheniia alpha-interferonom virusnogo hepatita C u lits s khronicheskim alkogolizmom.

Hepatitis C was treated with interferon alpha in chronic alcoholics and control subjects without alcoholism. The results show that ethanol is an independent risk factor in natural progression of chronic hepatitis C. Moreover, it dose-dependently reduces probability of getting a reliable response to interferon therapy. This makes using interferon alpha treatment of hepatitis C in chronic alcoholics doubtful.

[Chronic viral infection in patients with alcoholic liver involvement]. / Khronicheskaia virusnaia infektsiia u bol'nykh s alkogol'nym porazheniem pecheni.

AIM: Detection of viral hepatitides markers in patients with alcoholic damage to the liver. MATERIALS AND METHODS: Virological, immunological and histochemical tests were performed in 36 chronic alcoholics who had enlarged liver and/or abnormal hepatic characteristics. RESULTS: 60% of the examinees carried chronic HBV, HCV, HDV infection. The activity of chronic inflammation of hepatic parenchyma was associated with biological phase of the viral infection development. The degree of hepatic parenchyma morphological changes was unrelated to the virus type. (HBV, HCV, HDV). CONCLUSION: Alcoholic hepatic damages often combine with viral hepatitis.

[Clinical efficiency of high-dose interferon therapy in patients with chronic NCV hepatitis]. / Klinicheskaia éffektivnost' vysokodozodogo rezhima interferonoterapii u bol'nykh s khronicheskim NSV-gepatitom.

11 patients with confirmed chronic HCV-hepatitis were treated with high-dose interferon. 12 matched controls were treated conventionally. Higher response was registered in patients on the interferon treatment. Side effects were not related to the variant of interferon therapy in the studied population.

[Equipment for blood detoxication in critical care of patients]. / Apparat dlia detoksikatsii krovi pri kriticheskikh sostoianiiakh bol'nykh.

The paper deals with the development of a new more improved blood detoxicating system in critical patients. Based on the design of a [symbol: see text]-0.5 plasmapheresis device, the authors have designed a new [symbol: see text] 2-0.5 system, by including into the extracorporeal circuit the second rotor which cultures biologically active agents (hepatocytes, fragments of splenic and placental tissue) enhancing a patient's detoxification. The paper also outlines the operating principles of the [symbol: see text] K 2-0.5 device, its operational preparation and procedure.

[Interaction between the otolithic organ and semicircular canals of the vestibular apparatus in the system of directional orientation of man in space]. / Vzaimodeistvie otolitovogo organa i polukruzhnykh kanalov vestibuliarnogo apparata v sisteme uglovoi stabilizatsii cheloveka v prostranstve.

A mathematical model is suggested of the biological system of angular stabilization in space relative to the local vertical using measures whose parameters are near to the parameters of the semicircular canals and otolithic organ of the man. On the basis of computer simulation for physiologically adequate external stimulations contribution of each of measures to the total process of angular stabilization is evaluated.

[Reaction of the human vestibular apparatus to periodic effects of the ship-rocking type]. / Issledovanie reaktsii vestibuliarnogo apparata cheloveka na periodicheskie vozdeistviia tipa kachki korablia.

Reactions of the semicircular canals to periodic effects of the ship rolling type have been studied, using a mathematical model. The data obtained give evidence that during the above effects linear combinations of reactions of all semicircular canals may describe changes in the angular velocity of man's movement in an absolute (static) space. Besides, the common segment of the vertical semicircular canals (the common limb) allows a more accurate description of time changes in angular velocity. The mathematical model has demonstrated the dependence of absolute angular velocity as approximated by the semicircular canals from head orientation as related to the body. In addition to general discussions about rolling effects on the semicircular canals, the paper presents calculations of such reactions as applied to a specific object, i. e. a medium-size trawler.

[Effect of centrifugal force on neck nystagmus in pigeons]. / Vliianie tsentrobezhnoi sily na sheinyi nistagm u golubei

The neck nystagmus and its changes under the influence of an otolith stimulus--centrifugal force were studied in pigeons. The results show that centrifugal forces exert a dynamic effect on the nystagmus.