[The correlation analysis of parameters of neurological deficit and quality-of-life in the patients after atherotrombotic stroke]. / Korreliatsionnyi analiz parametrov nevrologicheskogo defitsita i kachestva zhizni bol'nykh, perenesshikh aterotromboticheskii insul't.

AIM: To establish correlations between parameters of the neurological status of patients in the acute period and quality-of-life in the late recovery period of atherotrombotic stroke in carotid and vertebrobasilar areas. MATERIAL AND METHODS: One hundred and sixty-two patients, including 124 with carotid stroke and 28 with vertebrobasilar stroke, were examined. Quantitative parameters of the neurologic status were estimated during the hospitalization of patients. Quality-of-life assessed with the «SF-36 Health Status Survey¼ with the calculation of two parameters (mental (MH) and physical (PH) wellbeing) was evaluated 10-14 months after stroke. RESULTS AND CONCLUSION: Parameters of the neurologic status had an effect only on the PH domain of quality-of-life while MH was independent of the indicators studied. The initial NIHSS index and Rivermead Mobility Index had the greatest impact on PH in patients with carotid stroke. In patients with vertebrobasilar stroke, the strong correlation of PH with the age of patients and an index of independence, measured with the Rankin scale on the 14th day of hospitalization, was found.

[Effectiveness and safety of rufinamide at treatment of epilepsy with complications and drug-resistant epilepsy (according to meta-analysis data)]. / Effektivnost' i bezopasnost' lecheniya epilepsii rufinamidom (po dannym metaanaliza).

AIM: Meta-analysis was undertaken to evaluate rufinamide safety and effectiveness in numerous heterogeneous groups of patients with severe and drug resistant epileptic disorders. MATERIAL AND METHODS: There were 164 relevant articles available via medico-clinical periodic databases, but only 15 have been chosen suitable for meta-analysis. All together 1847 participants were included into common massive, with Lennox-Gastaut syndrome (LGS) and similar encephalopathy syndromes, and with drug-resistant partial epileptic forms. 1169 were administered rufinamide additionally to typical anti-epileptic medications (experimental group). 686 received treatment with common practice drugs without rufinamide (control group). RESULTS AND CONCLUSION: Patient with more than 50% seizures reduction were more numerous in rufinamide group (χ2=89.7 with р=0.000...; ОR=2.9 with 95% CI 2.3-3.7). Most frequent and statistically reliable complications of rufinamide use were headache/dizziness and nausea/vomiting. Rufinamide is safe and effective for treatment of different epilepsies including LGS and drug-resistant partial seizures. Rufinamide may be used as second-line adjuvant for routine neurologic practice.

[Quality of life of the patients who had an atherotrombotic stroke in the carotid artery territory]. / Kachestvo zhizni bol'nykh, perenesshikh aterotromboticheskiĭ insul't v karotidnoĭ sisteme.

AIM: To assess quality of life of patients with first-ever atherothrombotic stroke in the carotid artery territory 2 years after the disease onset. MATERIAL AND METHODS: Authors examined 119 patients. Quality of life was measured with the «SF-36 Health Status Survey¼ using two parameters: level of mental (MH) and physical (PH) health. A control group consisted of 20 sex- and age-matched healthy persons without neurological diseases. RESULTS: After two years, 67% of the patients assessed their health condition as satisfactory. In the patients, a decrease in PH was greater compared to MH than in controls. CONCLUSION: In post-stroke period, patients for a long time had lower quality of life indices with marked physical impairment. Elimination of or reduction in the focal neurological deficit that led to the decrease in the level of physical wellbeing may be considered as a significant rehabilitation reserve.