A chronic Access Port model for direct delivery of drugs into the intestine of conscious dogs.

Gastric physiologic properties and emptying can significantly affect the stability and absorption of drugs given orally. A method to deliver drugs directly into the intestines and peritoneal cavity in conscious dogs by using a modified Vascular-Access Port (VAP) was developed and validated. Modified silastic VAP catheters size 7 or 9 French were placed in the duodenum, jejunum, colon, and/or peritoneal cavity in nine adult male dogs. Catheter placement was validated in six dogs by using contrast radiography and by monitoring the fecal excretion of blood after injection of blood via the VAP directly into the intestines. Three dogs were successfully used to evaluate the absorption of a peptide that inhibits platelet aggregation. Results showed this to be a feasible, easily validated model for delivering drugs directly into the intestines of conscious dogs.

A new portacaval shunt.

A new prosthetic, segmented polyether polyurethane portacaval shunt featuring quick-connect anastomotic ends was constructed and evaluated as part of a short-term pharmacokinetic study. The shunts were easily implanted, did not require the use of anticoagulants, and decreased the operative time normally required for this surgical preparation. There was no evidence of thrombosis or venous stasis associated with the shunts.

Fabrication method for endotracheal tubes for sheep, goats, and calves.

A reliable, inexpensive, and reusable endotracheal tube for sheep, goats, and calves was designed and constructed. The tube consisted of reinforced polyvinylchloride tubing with a segmented polyether polyurethane coated latex cuff. These materials were used to make a durable tube which allowed easy intubation.