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1.
J Med Case Rep ; 17(1): 432, 2023 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-37845768

RESUMO

BACKGROUND: Details of improved gait ability after wide resection of soft tissue sarcomas that necessitate removal of portions of the quadricep muscle have not yet been reported. We describe a patient with improved gait ability following a rehabilitation program after wide resection of a soft tissue sarcoma that included four components of the quadricep muscle. CASE PRESENTATION: An 85-year-old Japanese man underwent wide resection of an undifferentiated pleomorphic sarcoma that included portions of the quadriceps femoris muscle. The rectus femoris, vastus medialis, sartorius, and vastus intermedius were separated in the maximally bulging region of the tumour. Three weeks postoperatively, gait exercise was initiated using a rigid knee orthosis with a dual-adjustable lock knee. The contraction loading of the knee extension muscle was controlled by adjusting the hinge motion range of the orthosis as follows: fully extended, fixed knee 0°-30°, and free range. Under this regimen, he could walk independently without a rigid orthosis within 5 weeks postoperatively but could not sit on his heels during daily living activities. At six months, there was no clinical evidence of recurrent tumours or complications. CONCLUSIONS: Postoperative gait ability might be affected by not only the number of resected muscles but also by the function of the separated muscles and the cross-sectional area of the remaining muscle. Gradually loaded exercise of the knee extension muscles using an orthosis could result in an improved gait motion for patients who undergo wide resection of a sarcoma that includes four components of the quadriceps femoris.


Assuntos
Sarcoma , Neoplasias de Tecidos Moles , Masculino , Humanos , Idoso de 80 Anos ou mais , Músculo Quadríceps , Recidiva Local de Neoplasia , Articulação do Joelho/cirurgia , Sarcoma/cirurgia , Aparelhos Ortopédicos , Neoplasias de Tecidos Moles/cirurgia
2.
Cureus ; 15(1): e33420, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36751226

RESUMO

Treatment strategies for patients with cervical spinal cord injury (CSCI) without major bone injury in the acute phase are under debate. For CSCI without major bone injury, conservative treatment is often the first choice owing to the absence of fractures and spinal column instability. However, treatment of CSCI without major bone injury by either surgery or conservative measures remains controversial. We described a case of a 48-year-old man with cervical American Spinal Cord Injury Association Impairment Scale (AIS) grade C tetraplegia as a result of a fall. Computed tomography scan and magnetic resonance imaging revealed no fractures and widespread T2-hyperintense signal changes in the cord centered on C3-4. The paralyzed condition of his lower extremities remained unchanged with conservative treatment for eight months after the injury. Therefore, he underwent decompression surgery eight months after the injury. At two weeks postoperatively, he could transfer and walk using a walker. After discharge, he underwent regular home-visit rehabilitation and gradually improved his physical functions, including gait ability one year postoperatively. We encountered a case in which surgery and intensive rehabilitation eight months after the injury improved motor function. The combination of surgery in the chronic phase and postoperative rehabilitation can therefore improve the outcomes. The message in this paper is by no means a recommendation for "late surgery." However, we suggested that surgical treatment might be an option if the functional improvement is poor, as even quite late surgery can provide functional improvement.

3.
Prog Rehabil Med ; 7: 20220062, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36561294

RESUMO

Background: Auto-mobilization (AM) is a treatment method that patients can use by themselves for pain relief. We report the case of a patient diagnosed with cervical disk herniation (CDH), with frequent recurrences of upper limb numbness and neck pain. The patient experienced a favorable outcome after cervical spine AM, as evidenced by the immediate and long-term relief of his symptoms as well as changes observed through imaging. Case: A 33-year-old-man diagnosed with CDH presented with frequent recurrences of upper limb numbness and neck pain. Radiographic and T2-weighted magnetic resonance imaging scans revealed cervical spine kyphosis and a left paracentral to intraforaminal lesion with disk herniation of protrusion type at C4-5. He was started on AM to elicit physiological lordosis of the cervical spine. This treatment was painless and did not cause withdrawal on discontinuation. AM improved the mobility of his cervical lower facet joints, reduced dysesthesia, and eliminated pain. Improvement in neck pain and cervical kyphosis and reduction of disk herniation were observed 2 years after initiating the intervention. Discussion: Appropriate physical therapy evaluation and cervical AM for this patient resulted in symptomatic relief and indirect disk herniation regression. By adding imaging findings to clinical findings, the effect of AM could be visualized, and the reliability of the therapeutic effect was further enhanced.

4.
J Strength Cond Res ; 36(2): 379-385, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-32028461

RESUMO

ABSTRACT: Matsuo, H, Kubota, M, Shimada, S, Kitade, I, Matsumura, M, Nonoyama, T, Koie, Y, Naruse, H, Takahashi, A, Oki, H, Kokubo, Y, and Matsumine, A. The effect of static stretching duration on muscle blood volume and oxygenation. J Strength Cond Res 36(2): 379-385, 2022-Muscle blood volume increases due to stretching; however, the minimum duration of stretching to sustainably increase the muscle blood volume after stretching has not yet been elucidated. This study examined whether the duration of static stretching influenced the muscle blood volume and oxygenation. Ten healthy male subjects participated in this controlled laboratory study. Static stretching of the gastrocnemius muscle was performed for 5 durations (20 seconds, and 1, 2, 5, and 10 minutes). Changes in both the total-Hb (ΔtHb), as an index of blood volume, and tissue oxygenation index (ΔTOI) from baseline were determined using near-infrared spectroscopy. Both the ΔtHb and ΔTOI decreased during stretching and increased after stretching. The minimum value of ΔtHb during stretching did not differ in each of the 5 durations, but minimum ΔTOI progressively decreased with longer durations of stretching. The peak value of ΔtHb after stretching increased with longer durations of stretching. The value of ΔtHb at 5 minutes after the end of stretching increased with more than 2 minutes of stretching compared with 20 seconds of stretching, although the value of ΔtHb did not significantly differ between the 2, 5, and 10 minutes' durations. These findings suggest that a longer duration of stretching elicits a decrease in muscle oxygenation during stretching, and an increase in both the muscle blood volume and oxygenation after stretching. The results indicated that the minimum duration of stretching to sustain an increase in the muscle blood volume after stretching is 2 minutes.


Assuntos
Exercícios de Alongamento Muscular , Volume Sanguíneo , Humanos , Masculino , Músculo Esquelético , Fenômenos Fisiológicos Respiratórios , Espectroscopia de Luz Próxima ao Infravermelho
5.
PLoS One ; 15(7): e0236652, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32730298

RESUMO

Osteoporotic hip fracture is a major public health issue. Estimation of the outcome and maximization of functional recovery after fracture is very important in the treatment of older patients. The purposes of this study were to clarify the functional outcomes after the treatment of hip fracture and to identify the factors that influence functional recovery. In the present study, 228 patients admitted to an acute-care hospital from January 2016 to June 2018 were evaluated. The patients were categorized into a trochanteric fracture group (n = 128) and a neck fracture group (n = 100). We retrospectively reviewed their ambulation ability 6 months after fracture using the Functional Ambulation Category (FAC) score. The other survey items were the presurgical duration, length of hospital stay, time until beginning to walk using parallel bars, complications affecting treatment, and mortality rate. The 6-month follow-up rate was 54.4% (n = 124). The results showed that the patients with trochanteric fracture were significantly older than those with neck fracture (86 vs. 82 years, respectively; p = 0.03). In total, 85.0% of patients with trochanteric fracture and 92.2% of patients with neck fracture were independent ambulators before injury (FAC score of 4 or 5). The FAC score 6 months after fracture was positively correlated with the FAC score before fracture and at discharge (all p<0.001) and negatively correlated with patient age (p<0.001) and presurgical duration for patients with neck fracture (p = 0.04). There was no statistically significant correlation with the length of hospital stay or the time until beginning to walk using parallel bars. In conclusion, patients with trochanteric fractures were older than those with neck fractures. In both fracture types, walking recovery 6 months after hip fracture was related to the FAC score before injury and at discharge from an acute-care hospital but not to the time until beginning to walk using parallel bars.


Assuntos
Fraturas do Quadril/cirurgia , Recuperação de Função Fisiológica , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Fraturas do Colo Femoral/cirurgia , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Caminhada
6.
Spine J ; 20(7): 1096-1105, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32032676

RESUMO

BACKGROUND CONTEXT: Although a few reports have shown a change in gait motion in cervical myelopathy (CM) patients using a three-dimensional (3D) gait analysis system, there has been no detailed quantitative investigation of their gait including musculoskeletal modeling parameters. Also, 3D gait analysis using a classification of severity has not been substantiated. PURPOSE: This study aimed to investigate kinematic, kinetic, and musculoskeletal modeling parameters of gait motion in CM patients using a severity classification. STUDY DESIGN: Prospective cohort and cross-sectional study. PATIENT SAMPLE: Forty-two patients with CM and 40 healthy, age-matched volunteers. OUTCOME MEASURES: Lower extremity spatiotemporal, kinematic, kinetic, and musculoskeletal modeling parameters. METHODS: Subjects were classified as to its severity using the Japan Orthopaedic Association score excluding the upper extremity items: group 1 (>10 points); group 2 (7-9 points); and group 3 (<6 points). A 3D motion analysis system and musculoskeletal modeling software were used to obtain the spatiotemporal, kinematic (the lower extremity joints angles in the sagittal plane), kinetic (the lower extremity joints moment and power in the sagittal plane), and musculoskeletal modeling parameters (the muscle-tendon length and velocity). RESULTS: Genu recurvatum, deteriorated lower-extremity joint motion, and muscle-tendon velocity were observed in severe CM patients (group 3). Muscle-tendon velocities of the long head of the biceps femoris in controls and mild CM patients (groups 1 and 2) showed a bimodal waveform in the negative direction during the initial contact and preswing phases, whereas these characteristics were not present in severe CM patients (group 3). CONCLUSIONS: The strategies of the knee joint moment during gait motion in severe CM patients were different from those of the normal gait pattern. The imbalance between agonist and antagonist muscle tissue during gait could be involved in the occurrence of genu recurvatum. It might be important for CM patients to consider improving the contraction or extension velocity of the biceps femoris muscle during each gait phase from the early stages of symptoms.


Assuntos
Marcha , Doenças da Medula Espinal , Fenômenos Biomecânicos , Estudos Transversais , Humanos , Japão , Estudos Prospectivos , Amplitude de Movimento Articular
7.
Spine (Phila Pa 1976) ; 44(24): E1452-E1460, 2019 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-31361728

RESUMO

STUDY DESIGN: A retrospective study. OBJECTIVE: The aim of this study was to assess the outcome, perioperative complications, and prognostic factors of anterior cervical decompression and fusion (ACDF) in patients with cervical ossification of posterior longitudinal ligament (OPLL). SUMMARY OF BACKGROUND DATA: There is little information on the long-term surgical outcome of ACDF including postsurgical remnant ossified spinal lesion. METHODS: Between 1993 and 2013, 80 patients with cervical myelopathy towing to OPLL underwent ACDF at our hospital. Among these, 42 patients were followed-up for at least 5 years and their data were analyzed. RESULTS: The mean follow-up period was 7.9 ±â€Š2.8 years, and the overall improvement rate was 59.2% ±â€Š15.0%. Although 12 (15.0%) perioperative complications were observed in 6 patients, accompanied by neurological deterioration, none of the patients had chronic complications. Multivariate logistic regression analysis that included the preoperative Japanese Orthopaedic Association (JOA) score, type of OPLL, occupying ratio of OPLL, and number of fused segments and increase in the transverse area of the cord identified the latter parameter as the only independent and significant determinant of radiological and clinical improvement of >50%. Among the patients with remaining ossified spinal lesions out of the decompressed range (16 patients), postoperative progression was observed in 6 cases (14.3%) who were all of the mixed type; floated lesions within the decompressed range did not show progression during the follow-up. Adjacent segment degeneration was seen in nine (21.4%) patients, and neurological signs and symptoms were seen in only three of the nine patients and only one patient required revision surgery. CONCLUSION: The long-term clinical outcome of patients with cervical OPLL after ACDF is considered satisfactory. Surgery-related complications and adjacent segment diseases should not be reasons to avoid ACDF. Care should be taken in selecting ACDF with postsurgical remnant ossified spinal lesion, as it could progress postoperatively especially in the mixed type OPLL. LEVEL OF EVIDENCE: 4.


Assuntos
Descompressão Cirúrgica , Ossificação do Ligamento Longitudinal Posterior/cirurgia , Doenças da Medula Espinal/cirurgia , Fusão Vertebral , Adulto , Idoso , Idoso de 80 Anos ou mais , Vértebras Cervicais , Descompressão Cirúrgica/efeitos adversos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/efeitos adversos , Ossificação do Ligamento Longitudinal Posterior/complicações , Ossificação do Ligamento Longitudinal Posterior/diagnóstico por imagem , Período Pós-Operatório , Radiografia , Estudos Retrospectivos , Doenças da Medula Espinal/etiologia , Fusão Vertebral/efeitos adversos , Resultado do Tratamento
8.
J Orthop Sci ; 24(2): 230-236, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30361169

RESUMO

BACKGROUND: Even though the number of patients with cervical spinal cord injury (CSCI) without major bone injury is increased, the treatment with either surgery or conservative measures remains controversial. The aim of this study was to assess its prognostic value in the prediction of useful motor recovery and to clarify whether the patients should be treated surgically are present. METHODS: We reviewed 63 patients (conservative, n = 36; surgery, n = 27) with CSCI without major bone injury (Frankel A-C). Neurological examination using modified Frankel grade at admission and 6 months after injury and International Stoke Mandeville Games (ISMG) classification at subacute phase after injury, MRI findings including rate of spinal cord compression, extent of cord damage and type of signal intensity change were assessed. RESULTS: Thirty-five of 63 patients were improved to walk at 6 months after injury. In multivariate analysis, rate of spinal cord compression, extent of cord damage and improvement of ISMG grade were associated with useful motor recovery. There was no difference in the neurological improvement between conservative and surgical groups. However, patients with spinal cord compression of ≥33.2% showed better motor recovery at 6 months post-injury after surgery than those treated conservatively. There was a positive correlation between the improvement of ISMG grade at subacute phase and Frankel grade at 6 months post-injury. It is difficult to obtain satisfactory surgical outcome for patients with Frankel A or B1 on admission and/or extensive spinal cord damage on T2-weighted image. CONCLUSIONS: Conservative treatment is recommended for patients with CSCI without major bone injury. However, we also recommend surgical treatment to acquire walking ability for patients with spinal cord compression of ≥33.2% and low ISMG grade at subacute phase. Among such patients, careful consideration should be given to patients with Frankel A or B1 and/or extensive spinal cord damage on MRI.


Assuntos
Tratamento Conservador/métodos , Descompressão Cirúrgica/métodos , Fraturas Ósseas/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Traumatismos da Medula Espinal/cirurgia , Caminhada/fisiologia , Adulto , Idoso , Vértebras Cervicais/lesões , Estudos de Coortes , Feminino , Fraturas Ósseas/terapia , Humanos , Escala de Gravidade do Ferimento , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Exame Neurológico/métodos , Prognóstico , Curva ROC , Estudos Retrospectivos , Medição de Risco , Compressão da Medula Espinal/diagnóstico por imagem , Compressão da Medula Espinal/terapia , Traumatismos da Medula Espinal/diagnóstico por imagem , Traumatismos da Medula Espinal/terapia , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do Tratamento
9.
Gait Posture ; 61: 163-168, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29413784

RESUMO

BACKGROUND: A few previous studies have reported a change in gait motion in idiopathic normal pressure hydrocephalus (iNPH) patients after shunt surgery compared with before shunt surgery; however, there has been no detailed quantitative investigation of gait, including kinetic and kinematic parameters. Furthermore, the relationship between gait parameters and magnetic resonance (MR) imaging has not been confirmed. RESEARCH QUESTION: We investigated the gait motion in patients with iNPH, and evaluated the relationship between kinetic gait parameters and MR imaging before and after shunt surgery. METHODS: The subjects were 12 patients with iNPH who could walk 10 m without aids. A three-dimensional motion analysis system was used to obtain the spatiotemporal, kinetic, and kinematic parameters before and after surgery. Relationships between each gait parameter and MR imaging were assessed. RESULTS: The post-shunt walking speed and step length were increased compared with pre-shunt values. The post-shunt evaluation showed increased range of motion of the hip, knee, and ankle joints in the sagittal plane during the gait cycle. The peak flexion moment of the hip during the stance phase was greater after shunt surgery. The improvement rate of the Evans index was significantly correlated with the improvement rate of walking speed, and the total ranges of motion of the hip and ankle joints in the sagittal plane. SIGNIFICANCE: The propulsive force of the hip and ankle joints was regained after shunt surgery. Normalization of the Evans index could predict improvement in propulsive force after shunt surgery in iNPH.


Assuntos
Derivações do Líquido Cefalorraquidiano/métodos , Marcha/fisiologia , Hidrocefalia de Pressão Normal/fisiopatologia , Imageamento por Ressonância Magnética/métodos , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Feminino , Humanos , Hidrocefalia de Pressão Normal/diagnóstico por imagem , Hidrocefalia de Pressão Normal/cirurgia , Masculino , Amplitude de Movimento Articular/fisiologia , Caminhada/fisiologia , Velocidade de Caminhada/fisiologia
10.
J Jpn Phys Ther Assoc ; 17(1): 22-30, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25792905

RESUMO

We investigated the histopathological and immunohistochemical effects of loading on cartilage repair in rat full-thickness articular cartilage defects. A total of 40 male 9-week-old Wistar rats were studied. Full-thickness articular cartilage defects were created over the capsule at the loading portion in the medial condyle of the femur. Twenty rats were randomly allocated into each of the 2 groups: a loading group and a unloading group. Twenty rats from these 2 groups were later randomly allocated to each of the 2 groups for evaluation at 1 and 2 weeks after surgery. At the end of each period, knee joints were examined histopathologically and immunohistochemically. In both groups at 1 and 2 weeks, the defects were filled with a mixture of granulation tissue and some remnants of hyaline cartilage. The repair tissue was not stained with toluidine blue in both groups. Strong staining of type I collagen was observed in the repair tissue of both groups. The area stained with type I collagen was smaller in the unloading group than in the loading groups, and the stained area was smaller at 2 weeks than at 1 week. In the staining for type II collagen, apparent staining of type II collagen was observed in the repair tissue of both groups at 1 week. At 2 weeks, there was a tendency toward a higher degree of apparent staining in the loading group than in the unloading group. Accordingly, these results indicated that loading and unloading in the early phase of cartilage repair have both merits and demerits.

11.
NMC Case Rep J ; 1(1): 20-23, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28663947

RESUMO

We examine the quantitative changes in the gait motion of patients with cervical spinal cord injuries (CSCIs) before and after the intrathecal baclofen (ITB) screening test. The subjects were three patients with CSCI, who exhibited spasticity in the lower extremities. They could all walk 10 or more meters with/without aids. All patients were subjected to the ITB screening test, in which they had gabalon (50 µg) injected into their spinal column via paramedian puncture at the L3-4 level. The subjects had their ankle clonus; patellar tendon reflex; and modified Ashworth scale, Berg balance scale, Spinal Cord Independence Measure, and 10 -meter walk test (10MWT) assessed before and 5 hours after the ITB screening test. At 5 hours after the ITB screening test, all of the patients exhibited decreased spasticity in static position, and improved balance. There were no differences in the abilities of any of the patients to perform ADL. One patient did not change the spatiotemporal gait motion parameters (walking time, step count, and step length in the 10MW T). Therefore, the pomp implantation for ITB therapy was not performed. Two patients who had suffered CSCI more than 20 years ago exhibited a reduced walking time, increased step count, and step length. Out of the two patients one received the pomp of implantation after ITB screening test, and the other was planned to operate. The spatiotemporal gait motion parameters might be one of the useful tests to decide the pomp implantation for CSCI patients who hope improvement of gait ability.

12.
J Orthop Sci ; 12(5): 451-7, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17909930

RESUMO

BACKGROUND: The purpose of this study was to investigate gait characteristics of patients with bilateral hip osteoarthritis (BHO) independent of walking speed. METHODS: We measured gait parameters in 12 BHO patients during free walking activities and in 12 normal adults during both free walking and slow walking activities using a three-dimensional computerized gait analysis system. RESULTS: Patients with BHO had a lower walking speed, step length, and cadence than normal subjects during free walking. When compared with normal subjects walking at a slow speed, the walking speed difference among BHO patients disappeared, although BHO patients retained a relatively high cadence. Kinematic and kinetic factor analysis of BHO patients at free speed compared to normal subjects walking at a slow speed showed a forward-tilted pelvic angle in the BHO patients that dropped to that of the ipsilateral side during the stance phase. The peak extension and abduction angle of the hip and the peak abduction moment of the hip were all low, whereas the peak generation power of the ankle was high in BHO patients. CONCLUSIONS: Gait characteristics of patients with BHO, independent of walking speed, were as follows: (1) increased cadence and ankle generation power; (2) reduced step width, hip extension, and abduction angle as well as a lower hip abduction moment; (3) maintained forward tilting of the pelvis during gait cycle; and (4) appearance of a dropped pelvis during the stance phase.


Assuntos
Marcha/fisiologia , Articulação do Quadril/fisiopatologia , Cinese , Osteoartrite do Quadril/fisiopatologia , Caminhada , Feminino , Humanos , Pessoa de Meia-Idade , Movimento , Osteoartrite do Quadril/diagnóstico , Índice de Gravidade de Doença
13.
Arch Phys Med Rehabil ; 87(11): 1436-41, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17084116

RESUMO

OBJECTIVE: To determine the effects of lateral wedged insoles on knee kinetics and kinematics during walking, according to radiographic severity of medial compartment knee osteoarthritis (OA). DESIGN: A prospective case control study of patients with medial compartment OA of the knee. SETTING: Gait analysis laboratory in a university hospital. PARTICIPANTS: Forty-six medial compartment knees with OA of 23 patients with bilateral disease and 38 knees of 19 age-matched healthy subjects as controls. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: We measured the peak external adduction moment at the knee during the stance phase of gait and the first acceleration peak after heel strike at the lateral side of the femoral condyles. Kellgren and Lawrence grading system was used for radiographic assessment of OA severity. RESULTS: The mean value of peak external adduction moment of the knee was higher in OA knees than the control. Application of lateral wedged insoles significantly reduced the peak external adduction moment in Kellgren-Lawrence grades I and II knee OA patients. The first acceleration peak value after heel strike in these patients was relatively high compared with the control. Application of lateral wedged insoles significantly reduced the first acceleration peak in Kellgren-Lawrence grades I and II knee OA patients. CONCLUSIONS: The kinetic and kinematic effects of wearing of lateral wedged insoles were significant in Kellgren-Lawrence grades I and II knee OA. The results support the recommendation of use of lateral wedged insoles for patients with early and mild knee OA.


Assuntos
Aparelhos Ortopédicos , Osteoartrite do Joelho/reabilitação , Índice de Gravidade de Doença , Sapatos , Idoso , Fenômenos Biomecânicos , Estudos de Casos e Controles , Feminino , Marcha , Humanos , Masculino , Osteoartrite do Joelho/fisiopatologia , Estudos Prospectivos , Caminhada
14.
Arch Phys Med Rehabil ; 86(3): 527-33, 2005 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15759240

RESUMO

OBJECTIVE: To investigate changes in axonal flow after nerve root compression by using immunohistochemical techniques to detect calcitonin gene-related peptide (CGRP), which is thought to be involved in pain sensation. DESIGN: Experimental, controlled study. SETTING: University medical school in Japan. ANIMALS: Forty adult mongrel dogs (weight, 7-15kg). INTERVENTIONS: In dogs, the lumbar nerve roots were compressed using 4 types of clips with different pressures. Changes of CGRP levels in the spinal dorsal horn, dorsal root, and dorsal root ganglia (DRG) were examined immunohistochemically after compression for 24 hours or for 1 week. MAIN OUTCOME MEASURES: CGRP-positive neurons and CGRP-positive fibers. RESULTS: After compression, axonal flow in the dorsal root was impaired, accumulation of CGRP was observed distal to the site of compression, and the number of DRG cells showing positively for CGRP decreased. Compression for 1 week resulted in a decrease in the number of CGRP-positive fibers in the spinal dorsal horn. CONCLUSIONS: These findings indicate that CGRP dynamics are modified by nerve compression.


Assuntos
Peptídeo Relacionado com Gene de Calcitonina/fisiologia , Neurônios Aferentes/patologia , Radiculopatia/patologia , Animais , Cães , Gânglios Espinais/patologia
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