Comparative toxicities of methicillin and nafcillin.

In a prospective, randomized study, 75 infants and children were treated with methicillin sodium and 74 were treated with nafcillin sodium. The two groups were comparable with regard to age, sex, duration of therapy, types off illnesses, etiologic bacteria, and bacteremia. Clinical responses were also comparable. The frequencies of fever, rash, eosinophilia, neutropenia, anemia, and abnormal hepatic enzymes were the same in the two groups. Two patients in each group had transient hematuria early in their course that resolved despite continued antibiotic therapy. Definite urologic toxic effect did not occur in patients who received nafcillin, while four (5.3%) of the methicillin-treated patients were judged to have this complication. In addition, six patients (8%) who received methicillin had questionable evidence of urologic toxic effect. It is concluded that methicillin and nafcillin have comparable clinical efficacy and adverse effects, with the exception that definite urologic toxic effect has been observed with nafcillin therapy.

Tetanos. Estudio de 54 casos. / Tetanus. Study of 54 cases

Con el proposito de analizar los resultados y compararlos con los de anos anteriores se revisaron los expedientes de 54 pacientes atendidos en el Hospital Nacional de Ninos con el diagnostico de tetano, en el periodo comprendido entre 1974 y 1979.Se observo un descenso significativo en la mortalidad general, pero sobre todo en los pacientes mayores de 1 mes de edad y una letalidad global del 20%, la cual es baja en comparacion con la de otros paises y con nuestras cifras anteriores. Se discutieron las posibles causas de estos resultados y se hicieron recomendaciones para lograr un descenso aun mayor de la morbilidad y de la mortalidad