RESUMO
Globally, the production of zinc oxide nanoparticles (ZnO NPs) increased due to its wide applications including cosmetics, paints etc., and gets accumulated in the environment during their production, use or end-of-life. The toxic effects of the NPs vary with the presence of various surface modification agents. In the current report, toxic effect of bare and capped ZnO NPs with polymeric surface modifying agent including polyvinyl alcohol (PVA), polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) is studied against adult as well as embryonic zebra fish. The surface capped NPs showed great variation in toxicity levels. It was observed that ZnO-PVA showed highly reduced toxic effects relative to ZnO-PEG and ZnO-PVP. Further, various environmental agents including humic acid can also have an impact on NPs toxicity. ZnO particles showed increased toxic effect in humic acid presence. The uptake of ZnO particles by D. rerio was high in the order of PVP-, PEG- and PVA- followed by bare-ZnO. The current investigation found that ZnO NPs dissolution and uptake are the major factors which cause the toxicity against adult as well as embryonic zebra fishes respectively.
