RESUMO
In 3 groups of women (1. with pathological hyperprolactinemia, but low estradiol level--19 patients; 2. with pathological hyperprolactinemia, but high estradiol level--17 patients; 3. 16 healthy control women) the level of prolactin, estradiol, cortisol, total cholesterol, triglycerides and apolipoproteins A-I, A-II and B in serum was estimated together with routine clinical examination. In both hyperprolactinemic groups a significant decrease of apolipoprotein A-I and A-II was found, while in the group with high estradiol also a significant decrease of apolipoprotein B was observed. It is suggested that the increased level of prolactin results in an impairment of apolipoprotein biosynthesis and, in addition, in a group with high estradiol level also a lesion of liver function might occur which results in its decreased degradation.
Assuntos
Apolipoproteínas/sangue , Estradiol/sangue , Hiperprolactinemia/sangue , Fígado/patologia , Apolipoproteína A-I , Apolipoproteína A-II , Apolipoproteínas A/sangue , Apolipoproteínas B/sangue , Colesterol/sangue , Feminino , Humanos , Hidrocortisona/sangue , Hiperprolactinemia/patologia , Lipoproteínas HDL/sangue , Triglicerídeos/sangueRESUMO
Ten cases of monosomy X and caryotype 45,X, and 24 cases of the disorder with various forms of mosaicism are reported. The diagnostic significance of particular stigmata is underlined, and the possibility stressed to demonstrate a hidden pterygium colli by declining the patient's head laterally. Moreover, several peculiarities of individual cases are shown: In three girls with mosaicism, spontaneous puberty was observed, however, in two of them, it was followed by precocious menopause at the age of 14 and 18 years, respectively. The necessity of caryotyping in growth-retarded girls with secondary amenorrhoea or with a ren arcuatus or unilateral solitary kidney is emphasized. High values of urinary gonadotropins in girls without signs of puberty or with precocious menopause, indicate the need for substitution. This therapy leads to the appearence of secondary sex phenomena and menstruation, and at the same time prevents osteoporotic changes.
Assuntos
Aberrações dos Cromossomos Sexuais/diagnóstico , Cromossomos Sexuais , Cromossomo X , Anormalidades Múltiplas/genética , Adolescente , Adulto , Fatores Etários , Amenorreia/etiologia , Criança , Nanismo/etiologia , Feminino , Gonadotropinas/urina , Humanos , Lactente , Cariotipagem , Rim/anormalidades , Menopausa , Mosaicismo , PuberdadeRESUMO
The possibility of influencing the pituitary through the cerebral ventricle was examined. Synthetic LH-RH was introduced into the third ventricle of male and female rats and after 4 and 8 minutes, the plasma LH and FSH levels were determined by radioimmunoassay. Both in the male female rats, the LH levels were elevated, but FSH levels remained unchanged. The results show that, after intraventricular LH-RH administration, the LH level can be elevated within a few minutes. It is presumed that the non responsiveness of FSH level after LH-RH may support the view on a separate control of release of each of both hormones.
