[Effect of 4-amidinophenylpyruvic acid on the generalized Sanarelli-Shwartzman phenomenon]. / Vliianie 4-amidinofenilpirovinogradnoi kisloty na generalizovannyi fenomen Sanarelli-Shvarttsmana.

The influence of 4-amidinophenylpyruvic acid (APPA)--a synthetic thrombin inhibitor--on the incidence of disseminated intravascular coagulation was tested with the aid of a model of the generalized Sanarelli-Schwarzman phenomenon. After application of APPA the thrombogenesis in different organs subsided quite significantly.

[Inhibition of the activity of human serum cholinesterase by aminoalkyl benzenesulfonyl fluorides]. / Podavlenie aktivnosti chelovecheskoi syvorotochnoi kholinesterazy aminoalkilbenzol-sul'foftoridami

Aminoalkyl benzenesulfonyl fluorides, like organophosphates, act as irreversible inhibitors of serine proteinases by splitting off hydrogen fluoride to form an enzyme-inhibitor complex, stable in the physiological pH region. Several of these compounds are characterized by a higher rate of inhibition when trypsin is used and the second order rate constants are compared with those of organophosphates. On the other hand, upon inhibition of human serum cholinesterase by DFP and 4-nitrophenyl diethyl phosphate, some orders of magnitude higher than that of benzenesul fonyl fluorydes are observed. As shown by an oral toxicity study in mice similar differences exist with respect to LD50 values.