[Tolerance and effectiveness of propiverine hydrochloride in 752 patients with symptoms of detrusor hyperactivity and increased sensitivity and irritability of the urinary bladder: results of a study monitoring drug utilization]. / Snásenlivost a úcinnost propiverinhydrochloridu u 752 pacientu s príznaky hyperaktivity detruzoru, zvýsené senzitivity a drázdivosti mocového mechýre: výsledky studie sledování pouzití léku.

In a post-marketing surveillance study of 752 patients suffering from urgent incontinence, mixed urgent-stress incontinence, reflex incontinence, urgency and enuresis were treated with propiverine hydrochloride. Clinical efficacy of propiverine hydrochloride was verified by the improvement of symptoms related to detrusor hyperactivity, hypersensitivity and hyperreflexia during a 12-week surveillance period: daytime and overnight urinary incontinence, as well as the frequency, nocturia, urgency in day time and at night decreased. These results are well demonstrated by decreased pad use and statistically significant decrease of Gaudenz urgency score during treatment, confirming the efficacy of propiverine hydrochloride already proved in clinical trials. The safety profile of propiverine hydrochloride displayed characteristic anticholinergic symptoms (dry mouth, accommodation disorders, constipation, tiredness, dizziness) with decreasing incidence during the 12-week treatment period. The residual urine volume decreased also. Serious adverse events were observed rarely and could be explained by the lack of consideration of contraindications, warnings and interactions with other drugs. The positive risk-benefit relationship of propiverine hydrochloride in the treatment of detrusor hyperactivity, hypersensitivity and hyperreflexia was reconfirmed in this post-marketing drug surveillance study.

Triplicity of the malignant tumor of the urinary bladder.

Described report case of the patient after left nephrectomy, performed 18 years ago, for adenocarcinoma. Recently he has a simultaneous carcinoma of the bladder and the left ureter. Carcinoma of the bladder was treated with transurethral resection and electrocoagulation. Once checked, the hemorrhage was found from the left ureter, later, papilocarcinoma was diagnosed and the urethrectomy with the resection of the part of the wall of the bladder in the region of the estuary. Patient was in good condition 5 months after the operation. There is a review of others report cases.

[Diagnosis and treatment of benign subvesicular obstruction in benign prostatic hyperplasia without enlargement]. / Diagnostika a lécba benigní subvezikální obstrukce u nezvetsené benigní prostatické hyperplazie.

At the urological department of the First Surgical Clinic, Faculty of general Medicine Charles University in Prague from January 1977 to December 1986 922 men were operated on account of benign obstruction of the cervix. Ninety-one patients, i.e. 9.8%, with some common signs were subjected to clinical analysis. The criterium for inclusion in the group was the finding of a not enlarged, through on palpation frequently altered prostate, the finding of a histological, endoscopic, X-ray and urodynamic examination. The common sign of these patients was the presence of the disease in young age, a prolonged persistence (up to 20 years) and the frequent presence of supravesical congestion, sometimes with a diverticulum of the urinary bladder. The cause of the disease was dyssynergy, urethrovesical hypertrophy of the poesterior commissure, atrophy of the prostate, subtrigonal hyperplasia of the prostate and a secondary contracture. A transurethral operation was performed in 64 patients, a transvesicalar one in 24 and in three a XY plastic operation was made.