RESUMO
The article presents results of toxicity and hazard effects studies of alcoxicyandiphenyl CnH2n+ 1OC12H8CN with n = 1-8, octilcyandiphenyl and octildiphenyl. Toxicity parameters were established in animal tests and on isolated mitochondria, and inhibiting concentrations were calculated. Correlation was established between the alcoxicyandiphenyl detainment in high-performance liquid chromatography and the inhibition rate constant. The allowable and hazard levels are also specified.
Assuntos
Compostos de Bifenilo/toxicidade , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Nitrilas/toxicidade , Animais , Compostos de Bifenilo/análise , Compostos de Bifenilo/normas , Cromatografia Líquida de Alta Pressão , Técnicas In Vitro , Dose Letal Mediana , Concentração Máxima Permitida , Camundongos , Mitocôndrias Hepáticas/efeitos dos fármacos , Nitrilas/análise , Nitrilas/normas , Coelhos , RatosRESUMO
The article presents research data related to the biotransformation, intoxication mechanisms and pathogenic properties of chlortriazine dye-stuffs. All the dye-stuffs studies were characterized by similar intoxication properties and pathogenesis, and were related to the 3rd class of hazardous substances. The MAC for the organic chlortriazine dye-stuffs constituted 2 mg/m3.