1.
Arzneimittelforschung
; 24(12): 1988-90, 1974 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4217631
Assuntos
Anti-Inflamatórios/farmacologia , Ouro/farmacologia , Leishmaniose/tratamento farmacológico , Mycoplasma/efeitos dos fármacos , Administração Oral , Animais , Anti-Inflamatórios/uso terapêutico , Artrite Infecciosa/tratamento farmacológico , Artrite Reumatoide/tratamento farmacológico , Aurotioglucose/farmacologia , Aurotioglucose/uso terapêutico , Cricetinae , Ouro/uso terapêutico , Tiomalato Sódico de Ouro/farmacologia , Tiomalato Sódico de Ouro/uso terapêutico , Masculino , Camundongos , Fosfinas/farmacologia , Fosfinas/uso terapêutico
2.
Science
; 152(3730): 1760-1, 1966 Jun 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4287164
RESUMO
I-Adamantanamine hydrochloride, added to chick embryo cells, inhibited focus production upon subsequent inoculation of the cells with Rous and Esh sarcoma viruses. Addition of the chemical to suspensions of Rous and Esh viruses before they were added to chick cell cultures did not inactivate the viruses; and the addition to chick cells did not prevent plaque formation following their inoculation with Newcastle disease virus. This indicates that cells treated with 1-adamantanamine hydrochloride are capable of supporting viral replication, and these observations suggest that the drug inhibits growth of two oncogenic viruses by prevention of virus penetration, but not by a virucidal effect or cell intoxication.