[The possibility of using highly disperse iron for the directed transport of thyroxin in the body]. / Izuchenie vozmozhnosti ispol'zovaniia vysokodispersnogo zheleza dlia napravlennogo transporta tiroksina v organizm.

It has been ascertained that high-disperse powders of iron obtained by a thermochemical method in the process of formation of particles with pre-determined physical-and-chemical and medical-and-biological properties (essentially monodisperse, harmless, capable of exerting a bactericidal action, having an as-needed specific surface, corrosion resistance, withstanding sterilization heat up to 120 degrees C, allowing the magnetic characteristics to be controlled, etc.) can be used for directed transport of medicinal substances (thyroxin), hormone control, protection of the organism from overdosing of the administered drug preparations. Feasibility is shown of prolonged administration of thyroid hormones through the gastrointestinal wall with the aid of high-disperse ferromagnetic compositions as containers-carriers, which fact may secure the organism-controlled maintenance of the thyroid status in various thyroidal pathologies.

[Modeling the kinetics of regeneration of nonhomogeneous populations of hematopoietic cells during antitumor therapy]. / Modelirovanie kinetiki regeneratsii neodnorodnykh populiatsii krovetvornykh kletok v usloviiakh protivoopukholevoi terapii.

On the basis of a mathematical model imitating known properties of stem blood-forming cells regeneration of these cells was studied under the conditions of antitumor therapy depending on the regime of cytostatics introduction. Metotraxat and vinblastin preparations taken as an example, a principal possibility for theoretical analysis of toxic influence of cytotoxic therapy on stem hemopoietic cells was shown as well as modification of the schemes of introduction of antitumor preparations for decreasing their suppressing effect on hemopoiesis. Possible application of kinetic modelling of regeneration of the pool of stem hemopoietic cells for preclinical selection of the schemes of antitumor therapy, taking into account their effect on the hemopoiteic system is discussed.