[Contribution of the pathology chair of the Military Medical Academy to the development of military pathological anatomy]. / Rol' kafedry patologicheskoi anatomii Voenno-meditsinskoi akademii v razvitii voennoi patologicheskoi anatomii.

In 1930-1940 the pathology chair of the Military Medical Academy participated in organization of military pathological anatomy service. The activity of the chair staff goes in two directions: management of pathology service activity in the army both at peace and war time and research in combat pathology.

[Experimental and histological analysis of histogenesis and tissue regeneration (some results of the 20th century and perspectives on further research)]. / Eksperimental'no-gistologicheskii analiz gistogeneza i regeneratsii tkanei (nekotorye itogi XX v. i perspecktivy dal'neishikh issledovanii).

The article is devoted to theoretical analysis of certain achievements in the area of cellular and tissue biology. Evolutional laws of tissue development, theory of divergent differentiation of histological structures, conception of cellular-differon tissue organization, formulated earlier were completely suitable for analysis of processes of development and regeneration of living systems at different structural levels of organization. System-forming plasmalemmas, receptor-transductor and adaptive properties were related to most important characteristics of living systems that can be experimentally histologically analysed. Morphofunctional signs of differons and histions and tissue classifications were considered.

[Pathology of traumatic disease in wounded people]. / Patologicheskaia anatomiia travmaticheskoi bolezni u ranenykh.

The hemodynamic concept of TD pathogenesis and morphogenesis is based on the vascular response initiated by neuroendocrine mechanisms. Their effect in grave wounds is potentiated by blood loss, shock, endotoxicosis as well as inadequate therapy. Secondary damage to organs with clinical syndrome of their failure results from impaired correlation between the plasticity of histones and speed of microcirculatory alterations. Periodization of TD is suggested that takes into account its cyclicity and specificity of time distribution of therapeutic and diagnostic actions. Cerebral, pulmonary, renal, cardiac, gastro-intestinal and mixed forms of TD are distinguished.

[Complications and the proximate causes of death in typhoid]. / Oslozhneniia i neposredstvennye prichiny smerti pri briushnom tife.

The article analyses the 65 lethal cases by typhoid in the period 1980-1986 during an outbreak of infection among the servicemen of the 40-th Army. All the deceased had the age of 18-37, 79.8% of them were 18-20 years old. The most frequent complications were: myocarditis (84.6%), pneumonia (75.4%), hemorrhagic syndrome (50.8%), intestinal perforation (49.2%), intestinal ulcer hemorrhage (21.5%), pleuritis (20.0%), purulent complications (11.7%), endotoxic shock (12.3%). The structure of proximate causes of death was as following: perforative peritonitis (30.8%), pneumonia (20.0%), acute heart failure (13.8%), intestinal ulcer hemorrhage (12.3%), suprarenal hemorrhage (7.7%). The results obtained during this study prove the fact that this outbreak of epidemic infection had the features of classical typhoid.

[Measures for improving the quality of autopsies]. / Usloviia povysheniia kachestva autopsiinoi raboty.

The difficulties in performing the clinico-anatomical analysis of fatal outcomes and establishing the direct causes of death are discussed. It is suggested the automatic monitoring of basic physiologic indices with an obligatory magnetic registration of heart rate respiratory movements and encephalogram should be introduced into the practice of the surgical departments and departments of intensive therapy. This system should be implemented when the operation started, when the patient is in the critical condition, terminal state and resuscitation.

[Thanatological problems in cardiopulmonary surgery]. / Tanatologicheskie problemy v kardiopul'monal'noi khirurgii.

The pattern of immediate causes of death and types of terminal states (mechanisms of death) has been examined on the basis of thanatological analysis of 190 deaths occurred after operations on the heart (valve prosthesis) and lung (pneumonectomy). The differences in the thanatological profile of the respective surgical units are shown. Ways for reducing postoperative death in cardiopulmonary surgery are discussed.

[Pathogenesis and morphogenesis of acute pulmonary insufficiency during blood loss]. / Patogenez i morfogenez ostroi legochnoi nedostatochnosti pri krovopotere.

Postmortem clinical and anatomic lung examinations in patients dead of blood loss and the experiments on animals have shown that pathological changes underlying acute pulmonary failure are to a great extent due to disorders in pulmonary hemodynamics associated with the spasm in the arterial and venous vascular bed of the respiratory zone. Durable spasm of pulmonary veins promotes to hydrostatic pressure elevation and the onset of pulmonary edema even after blood loss replacement. Massive infusion-transfusion therapy performed in pulmonary hemodynamic disorders may aggravate pulmonary edema and lead to the onset of acute pulmonary failure.

[Thanatological analysis of traumatic disease]. / K tanatologicheskomu analizu travmaticheskoi bolezni.

The transition of trauma disease to the premortal period represents a qualitative leap of changing pathogenesis into thanatogenesis. Practically it means the appearance of such a condition of the patient which requires urgent measures of treatment directed to the correction of life-threatening alterations of homeostasis. The determination of some pathological process in the clinical picture of trauma disease as a possible direct cause of death presupposes the following prognosis of the type of the terminal condition, mechanism of death with the resulting conclusions concerning organization of curative measures.

[Various nosologic aspects of traumatic disease]. / Nekotorye nozologicheskie aspekty travmaticheskoi bolezni.

Trauma disease (TD) is a nosological unit which should be mentioned in diagnosis under the heading of combined main disease at the second place after trauma as a complex of local injuries. It has specific etiology, pathogenesis, semiotics and pathomorphology. Syndromes of insufficiency of different organs and systems are included in the typical plan of the TD course and should be considered as its manifestations. They characterize specificity of TD in the given patient and should be taken into consideration in developing a clinical classification.

[Electron microscopic study of archival material fixed in formalin]. / Ob élektronno-mikroskopicheskom issledovanii arkhivnogo, fiksirovannogo v formaline materiala.

A method for treatment of formalin-fixed and paraffin-embedded material for electron microscope examinations is described. Archive material may be examined in the electron microscope for the elucidation of some problems concerning conditions of intercellular structures, comparative size and localization in the cells of secrete granules, myofibrillar apparatus and various inclusions.

[Differential diagnosis of ulcerogenic tumors, insulomas and carcinoid tumors]. / K differentsial'noi diagnostike ul'tserogennykh opukholei, insulom i kartsinoidov.

The ultrastructural intactness of secretory granules in the cells of ulcerogenic tumours, insuloma and carcinoid were demonstrated in the operation material embedded in paraffin. Feature of similarity and differences in the tumours under study with respect to the size and shape, and distribution of granules in the cells were established.