Assuntos
Síndrome MELAS/diagnóstico , Transtornos Neurocognitivos/diagnóstico , Adulto , DNA Mitocondrial/genética , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Síndrome MELAS/genética , Síndrome MELAS/patologia , Transtornos Neurocognitivos/genética , Transtornos Neurocognitivos/patologia , Mutação PuntualRESUMO
The case registers of the patients admitted consecutively to the mother-and-baby unit of the Rotterdam University Hospital between 1967 and 1989 were studied in detail and classified according to the Research Diagnostic Criteria (RDC). The temporal relationship between delivery and the onset of symptoms for the different RDC categories is presented. A comparison is made with the classical concept of puerperal psychosis as it is held in the Netherlands. According to RDC, postpartum psychosis has 3 main phenomenological manifestations: affective, schizoaffective and unspecified functional psychosis. The classical concept of puerperal psychosis largely overlaps the RDC categories schizoaffective disorder and unspecified functional psychosis. The implications regarding the nosology of postpartum psychosis are discussed.
Assuntos
Hospitalização , Transtornos Psicóticos/classificação , Transtornos Puerperais/classificação , Adulto , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Escalas de Graduação Psiquiátrica/estatística & dados numéricos , Psicometria , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/psicologia , Transtornos Puerperais/diagnóstico , Transtornos Puerperais/psicologiaRESUMO
At three centres, 21 women at high risk for puerperal psychosis were given prophylactic lithium carbonate late in the third trimester of pregnancy or immediately after delivery. Only two of the women had a recurrence of their psychotic illness while on prophylactic lithium. One woman given lithium during third trimester had an unexplained stillbirth. Although a larger sample in a carefully controlled study is still required, there now seems to be grounds for the use of prophylactic lithium immediately after delivery in women not breastfeeding who have previously suffered from either puerperal psychosis or bipolar disorder.
Assuntos
Lítio/administração & dosagem , Transtornos Psicóticos/prevenção & controle , Transtornos Puerperais/prevenção & controle , Adolescente , Adulto , Transtorno Bipolar/prevenção & controle , Transtorno Bipolar/psicologia , Transtorno Depressivo/prevenção & controle , Transtorno Depressivo/psicologia , Feminino , Seguimentos , Humanos , Lítio/efeitos adversos , Carbonato de Lítio , Transtornos Psicóticos/psicologia , Transtornos Puerperais/psicologia , Recidiva , Fatores de RiscoRESUMO
Binding of paroxetine to blood platelet membranes was studied longitudinally in 20 healthy volunteers (11 men and 9 women) in order to determine seasonal and gender variations. Blood samples were obtained in September, December, March, and June, and repeated in September. A significant seasonal variation in the maximal number of binding sites (Bmax) was found. Men were found to have significantly lower (Bmax) values than women. Although the pattern of seasonal variation was not identical in men and women, no significant differences were detected. The affinity constant (KD) of paroxetine binding showed a significant seasonal variation. Men were found to have a significantly higher KD (lower affinity) than women. The pattern of seasonal variation was identical in men and women. These data support the evidence indicating a substantial seasonal effect on the serotonergic system, and show that in paroxetine binding studies, groups of subjects should be matched for season and gender.
