RESUMO
Protective action of cerebrokrast--a derivative from 1,4-dihydropyridine--on the processes of reparative osteogenesis in rats in case of combined action of chronic emotional-pain stress and trauma of mandibular was determined. It is stipulated by a antioxidant properties of cerebrokrast, as well as its stabilizing influence on glycoproteins and calcium homeostasis. The redeived data extend the idea about general-metabolic action of the investigated nootrop at the level of the whole organism and testify worthwhile of its use for prophylaxis of extreme conditions.
Assuntos
Antioxidantes/uso terapêutico , Di-Hidropiridinas/uso terapêutico , Traumatismos Mandibulares/tratamento farmacológico , Osteogênese/efeitos dos fármacos , Estresse Oxidativo/fisiologia , Animais , Cálcio/metabolismo , Doença Crônica , Glicoproteínas/metabolismo , Dor/tratamento farmacológico , Ratos , Ratos WistarRESUMO
On the model of acute stress in rats the dependence of accumulating of peroxide hydrogen from typological peculiarities of organism was determined. The highest level of activation of lipid peroxide oxidation coincides with maximally expressed impairing of stomach mucous membrane the dependence of processes of lipid peroxide oxidation in stress from typological peculiarities of organism was grounded as well as high effectiveness of correction of ulcerogenic effects by neuropeptide thymopentin.