RESUMO
Thirty women with asymptomatic genital gonococcal contamination were cured with one single i.m. injection of 1 g cefotaxime. Seven hours after treatment, the antibiotic level in cervical fluid was found equivalent to the minimal bactericidal concentration for gonococcus strains. But cefotaxime does not appear useful in the prevention of meningococcal pharyngeal carriage.
Assuntos
Portador Sadio/tratamento farmacológico , Cefalosporinas/uso terapêutico , Gonorreia/tratamento farmacológico , Adulto , Cefotaxima , Cefalosporinas/metabolismo , Muco do Colo Uterino/metabolismo , Feminino , Humanos , Testes de Sensibilidade Microbiana , Neisseria gonorrhoeae/efeitos dos fármacos , Saliva/metabolismoRESUMO
Over a period of 28 months, 605 strains of gonococci and 302 strains of meningococci have been isolated in an urban dispensary. The study was particularly concerned with the identification of gonococcal and meningococcal strains isolated from the patients sexual partners and with epidemiological distribution of the two species. There was only little seasonal variations in the occurrence of gonococcal infections. The frequency of meningococcal infections (which are only poorly transmitted, by the nasopharyngeal route) varied inconsistently during the period covered.