RESUMO
We studied microcirculation and a blood nitric oxide level in 30 females aged 23-63 years with overactive bladder (OAB) before and after administration of oxibutinin. We found that OAB patients have microcirculation disorders accompanied with elevation of nitric oxide in the blood. Oxibutin improved bladder microcirculation, normalized blood nitric oxide with resultant positive changes in clinical symptoms with less frequent voiding and alleviation of imperative disorders.
Assuntos
Microcirculação/fisiologia , Bexiga Urinária Hiperativa/fisiopatologia , Bexiga Urinária/irrigação sanguínea , Adulto , Feminino , Humanos , Fluxometria por Laser-Doppler , Pessoa de Meia-Idade , Óxido Nítrico/sangue , Ultrassonografia , Bexiga Urinária/diagnóstico por imagem , Bexiga Urinária Hiperativa/sangue , Bexiga Urinária Hiperativa/diagnóstico por imagem , Bexiga Urinária Hiperativa/etiologia , Urodinâmica/fisiologia , Adulto JovemRESUMO
Urodynamic parameters and bioelectric brain activity were studied in 30 females aged 24-66 years with overactive bladder (OAB) before and after transcranial magnetotherapy. It was found that OAB patients have disorders of bioelectric brain activity by two types of EEG patterns (I.A. Svyatogor classification)--thalamic and stem, Patients with thalamic type EEG benefit more from magnetotherapy higher efficacy of which manifests with regress of clinical symptoms and urodynamic improvement.
Assuntos
Eletroencefalografia , Tálamo/fisiopatologia , Estimulação Magnética Transcraniana , Bexiga Urinária Hiperativa/diagnóstico , Bexiga Urinária Hiperativa/terapia , Adulto , Idoso , Tronco Encefálico/fisiopatologia , Feminino , Humanos , Pessoa de Meia-Idade , Prognóstico , Resultado do Tratamento , Bexiga Urinária Hiperativa/fisiopatologiaRESUMO
Urodynamic and microcirculatory parameters were studied in 70 females aged from 21 to 70 years with hyperactive urinary bladder (HAUB) and 15 females free of diseases of the lower urinary tract. HAUB patients appeared to develop microcirculatory disorders in the wall of the bladder manifest as slow circulation resulting in detrusor hyperactivity responsible for HAUB symptoms. HAUB development is accompanied with urodynamic disorders - enhancement of detrusor contractility and that of urethral sphincter with growing amplitude of their electric activity leading to potentiation of bladder evacuatory ability. Different conservative treatments were evaluated for their influence on urodynamics and microcirculation in females with HAUB.
