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1.
Lik Sprava ; (6): 86-90, 1998 Aug.
Artigo em Russo | MEDLINE | ID: mdl-9844884

RESUMO

Effects were studied of diltiazem on parameters characterizing cardiohemodynamics, peripheral bloodflow, condition of atrial natriuretic peptide (ANUP), of cyclic nucleotides (cGMP), the renin-angiotensin system in patients with various manifestations of stenocardia. An inhibitory action of diltiazem on ANUP and cGMP secretion in a VEM-test was recordable but changes were not significant at the height of the drug action in rest. Improvement in myocardial contractility after the course treatment with the drug was accompanied by reduction in blood plasma levels of ANUP and cGMP. It is suggested that changes in ANUP concentration might be traced to improvement in the anginal course and to the drug effects such as lowering of myocardial oxygen demand, of pre- and afterload, improvement in the indices for myocardial contractility.


Assuntos
Angina Pectoris/tratamento farmacológico , Bloqueadores dos Canais de Cálcio/uso terapêutico , Diltiazem/uso terapêutico , Neurotransmissores/sangue , Adulto , Idoso , Angina Pectoris/sangue , Angina Pectoris/fisiopatologia , Angina Instável/sangue , Angina Instável/tratamento farmacológico , Angina Instável/fisiopatologia , Fator Natriurético Atrial/sangue , Fator Natriurético Atrial/efeitos dos fármacos , Bloqueadores dos Canais de Cálcio/farmacologia , Diltiazem/farmacologia , Tolerância ao Exercício/efeitos dos fármacos , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/sangue , Isquemia Miocárdica/tratamento farmacológico , Isquemia Miocárdica/fisiopatologia , Sistema Renina-Angiotensina/efeitos dos fármacos
2.
Ter Arkh ; 65(2): 55-8, 1993.
Artigo em Russo | MEDLINE | ID: mdl-9133014

RESUMO

A study is presented of hemodynamic effects and reactions of prostacyclin--thromboxane system in patients with stable (63 pts) and unstable angina pectoris (57 pts) who took aldizem 240 mg daily during 3 week. It was found that the aldizem improved clinical and hemodynamic indices and increased plasma concentration of 6-keto-PGF1 alpha and FPE2, but reduced TxB2 and PGF2 alpha. Also these changes depended on time of therapy: long-term therapy resulted in improvement of the prostacyclin-thromboxane balance.


Assuntos
Angina Pectoris/tratamento farmacológico , Angina Instável/tratamento farmacológico , Diltiazem/farmacologia , Neurotransmissores/sangue , Adulto , Idoso , Angina Pectoris/sangue , Angina Pectoris/fisiopatologia , Angina Instável/sangue , Angina Instável/fisiopatologia , Diltiazem/uso terapêutico , Avaliação de Medicamentos , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Prostaglandinas/sangue
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