Tunable exciton-polaritons emerging from WS2 monolayer excitons in a photonic lattice at room temperature.

Engineering non-linear hybrid light-matter states in tailored lattices is a central research strategy for the simulation of complex Hamiltonians. Excitons in atomically thin crystals are an ideal active medium for such purposes, since they couple strongly with light and bear the potential to harness giant non-linearities and interactions while presenting a simple sample-processing and room temperature operability. We demonstrate lattice polaritons, based on an open, high-quality optical cavity, with an imprinted photonic lattice strongly coupled to excitons in a WS2 monolayer. We experimentally observe the emergence of the canonical band-structure of particles in a one-dimensional lattice at room temperature, and demonstrate frequency reconfigurability over a spectral window exceeding 85 meV, as well as the systematic variation of the nearest-neighbour coupling, reflected by a tunability in the bandwidth of the p-band polaritons by 7 meV. The technology presented in this work is a critical demonstration towards reconfigurable photonic emulators operated with non-linear photonic fluids, offering a simple experimental implementation and working at ambient conditions.

Demonstration of a polariton step potential by local variation of light-matter coupling in a van-der-Waals heterostructure.

The large oscillator strength of excitons in transition metal dichalcogenide layers facilitates the formation of exciton-polariton resonances for monolayers and van-der-Waals heterostructures embedded in optical microcavities. Here, we show, that locally changing the number of layers in a WSe2/hBN/WSe2 van-der-Waals heterostructure embedded in a monolithic, high-quality-factor cavity gives rise to a local variation of the coupling strength. This effect yields a polaritonic stair case potential, which we demonstrate at room temperature. Our result paves the way towards engineering local polaritonic potentials at length scales down to atomically sharp interfaces, based on purely modifying its real part contribution via the coherent light-matter coupling strength g.

[Management of multiresistant bacteria in urology]. / Management multiresistenter Erreger in der Urologie.

Contamination and infection with extensive drug resistant (XDR) bacteria are increasing in urology with the exception of methicillin resistant Staphylococcus aureus (MRSA) (stabilization). They often lead to logistic and therapeutical problems. Only 30-50% of XDR cases are of exogenous origin. To slow this trend, screening, hygiene programs, isolation, decontamination, targeted therapy of symptomatic infections, education programs, and success controls should be applied. Furthermore, all regulatory and legal instructions should be followed. Local hygiene networks help to find apt measures for XDR control. It is important to balance hygiene measures against hygiene hysteria. To prepare urological instruments, a local instrument preparation plan that takes into consideration all legal instructions should be followed. The efforts in health system general prophylactic measures should be supported. Only with consistent implementation in all areas of daily life (health care, local environment, animal husbandry, and soil contaminated within the framework of animal husbandry) can a substantial reduction of XDR bacteria be achieved in the long term.

Changes in physical functioning among men and women aged 50-79 years in Germany: an analysis of National Health Interview and Examination Surveys, 1997-1999 and 2008-2011.

BACKGROUND: This study examines changes in physical functioning among adults aged 50-79 years in Germany based on data from two German National Health Interview and Examination Surveys conducted in 1997-1999 (GNHIES98) and 2008-2011 (DEGS1). METHODS: Using cross-sectional data from the two surveys (GNHIES98, n = 2884 and DEGS1, n = 3732), we examined changes in self-reported physical functioning scores (Short Form-36 physical functioning subscale (SF-36 PF)) by sex and age groups (50-64 and 65-79 years). Covariables included educational level, living alone, nine chronic diseases, polypharmacy (≥5 prescribed medicines), body mass index, sports activity, smoking and alcohol consumption. Multimorbidity was defined as ≥2 chronic diseases. Multivariable models were fitted to examine consistency of changes in physical functioning among certain subgroups and to assess changes in mean SF-36 PF scores, adjusting for changes in covariables between surveys. RESULTS: Mean physical functioning increased among adults aged 50-79 years between surveys in unadjusted analyses, but this change was not as marked among men aged 65-79 years who experienced rising obesity (20.6 to 31.5%, p = 0.004) and diabetes (13.0 to 20.0%, p = 0.014). Prevalence of multimorbidity and polypharmacy use increased among men and women aged 65-79 years. In sex and age specific multivariable analyses, changes in physical functioning over time were consistent across subgroups. Gains in physical functioning were explained by improved education, lower body mass index and improved health-related behaviours (smoking, alcohol consumption, sports activity) in women, but less so among men. CONCLUSIONS: Physical functioning improved in Germany among adults aged 50-79 years. Improvements in the population 65-79 years were less evident among men than women, despite increases in multimorbidity prevalence among both sexes. Changes in health behaviours over time differed between sexes and help explain variations in physical functioning. Targeted health behaviour interventions are indicated from this study.

Occupational risk factors for prostate cancer in an area of former coal, iron, and steel industries in Germany. Part 2: results from a study performed in the 1990s.

Currently, there is no established occupational risk factor for prostate cancer. However, in the 1980s, a hospital-based case-control study in the greater Dortmund area showed an elevated risk for hard coal miners and, based on few cases, for painters and varnishers. Therefore, approximately 10 yr later, a similar study regarding prostate cancer was performed in this area. In total, 292 patients with prostate cancer who underwent radical prostatectomy and 313 controls who underwent transurethral resection of a benign prostatic hyperplasia were investigated by questionnaire. All of them were operated on between 1995 and 1999. This study showed a decreased risk for prostate cancer in hard coal miners (odds ratio [OR] = 0.67, 95% confidence interval [CI] = 0.44-1.03). Occupational exposures related to an elevated risk for prostate cancer were exposures to combustion products (20% cases vs. 11% controls), colorants and dyes (19 vs. 13%), and cutting fluids (8 vs. 6%). The different prostate cancer risks for underground coal miners in two studies with a time interval of approximately 10 yr are striking. Factors to be discussed are the introduction of prostate-specific antigen (PSA) screening for prostate cancer and investigation of cases that underwent radical prostatectomy, where the disease in general is locally confined. Working conditions in the local underground coal mines improved over time but did not change markedly in the period of interest. In essence, the present study does not corroborate an elevated prostate cancer risk in former underground hard coal miners from the greater Dortmund area.

[Hygiene, Screening and Management of Multidrug-Resistant Pathogens (3MRGN, 4 MRGN, MRSA) in Urology]. / Hygiene, Screening und Management multiresistenter Erreger (3MRGN, 4 MRGN, MRSA) in der Urologie.

The increasing development of resistance to antibiotics has fatal consequences for the treatment of infectious diseases. One of the main causes is the inappropriate use, and therefore overuse, of these substances. Today, multidrug-resistant pathogens are a major problem for facilities of the public health system, especially for hospitals. Pathogens of particular interest are methicillin-resistant S. aureus and multidrug-resistant gram-negative bacteria. Adapted hygienic measures, effective screening and functioning management of affected patients are required to reduce the risk of infection for patients and staff as well as the spread of pathogens.

[Mortality follow-up of the German Health Interview and Examination Survey for Adults (DEGS) : methods and first results]. / Mortalitäts-Follow-up der Studie zur Gesundheit Erwachsener in Deutschland (DEGS) : Methodik und erste Ergebnisse.

OBJECTIVES: Within the framework of the German Health Interview and Examination Survey for Adults (DEGS), the Robert Koch Institute (RKI) conducted a nationwide mortality follow-up study. As there is no national mortality register in Germany, mortality and causes of death were investigated individually and under observance of state-specific data protection conditions. METHODS: The German Health Interview and Examination Survey 1998 (GNHIES98) provided the database including 7,124 participants aged 18-79 years. A total of 6,979 participants of GNHIES98 (98 %) who consented to be re-contacted were invited between October 2008 and October 2011 to also participate in the first data collection wave of DEGS (DEGS1). In this context, the vital status and the causes of death for deceased participants were assessed. Age- and sex-specific probabilities of survival and death rates were calculated and grouped by main causes of death according to ICD-10 groups. RESULTS: A total of 671 individuals (285 women, 386 men) died between the two survey contacts. For all deceased persons the date of death and for 539 (80.3 %) the causes of death could be determined. With a median follow-up time of 12.0 years, 8,0742.5 person years were available for survival analysis. The crude overall death rate amounted to 8.3 per 1,000 persons-years (women: 7.2; men: 9.5). Among 539 persons with available information on causes of death, 209 (38.8 %) were attributable to cardiovascular diseases, 188 (34.9 %) to cancer, 135 (25.0 %) to other causes, and seven (1.3 %) could not be unambiguously assigned. CONCLUSIONS: A mortality follow-up was successfully integrated in the longitudinal component of DEGS as part of the national health monitoring at the RKI. Death rates and cause-specific mortality in relation to highly prevalent chronic diseases and risk factors provide essential information for assessing the potential of prevention and quality of care among adults in Germany. This requires a regular and complete conduction of mortality follow-ups.

[Adjustable transobturatoric sling system in men : diagnosis and therapy recommendations to persistent pain]. / Adjustierbare transobturatorische Schlingensysteme beim Mann : Diagnostik und Therapieempfehlungen bei persistierenden Schmerzen.

BACKGROUND: In addition to artificial sphincters, male slings are recommended in the current guidelines for the treatment of persistent male stress incontinence. Today, several sling systems are available. Well-known complications of all sling systems are infections, erosion, residual urine/urinary retention, de novo urgency, and postoperative pain. DISCUSSION: Compared to retropubic implanted adjustable sling systems or functional slings, pain is more common after transobturatoric implantation of adjustable sling systems. Early postoperative pain is very common. In contrast, persistent pain is rare. However, the treatment of persistent pain is a large challenge for urologists and patients. There are no recommendations for diagnostic workup or treatment. RESULTS: After pain classification, pain management should be started with nonsteroidal anti-inflammatory drugs and/or tricyclic antidepressive agents, if necessary treatment escalation with a weak opioid and if not effective interventional procedures should be performed. Sling explantation is only necessary in rare cases.

[Prevalence of dyslipidemia among adults in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS 1)]. / Verbreitung von Fettstoffwechselstörungen bei Erwachsenen in Deutschland: Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1).

Interview and laboratory data from the first wave of the German health interview and examination survey for adults (DEGS1) from 2008 to 2011 were used to provide current estimates of the prevalence of dyslipidemia which are representative of the population in Germany 18 to 79 years of age. A total of 56.6 % of men and 60.5 % of women 18 to 79 years have elevated serum total cholesterol concentrations in excess of the currently recommended threshold of 190 mg/dL; 17.9 % of men and 20.3 % of women have highly elevated total cholesterol concentrations ≥ 240 mg/dL. A total of 19.3 % of men and 3.6 % of women have high density lipoprotein cholesterol concentrations below 40 mg/dL. The overall prevalence of dyslipidemia (total cholesterol ≥ 190 mg/dL or medical diagnosis of dyslipidemia) is 64.5 % for men and 65.7 % for women. Of these, more than half of both men and women have previously undiagnosed dyslipidemia. Among persons with known dyslipidemia, 30.8% take lipid-lowering medication. Dyslipidemia is widely prevalent among adults in Germany. More in-depth analyses will examine time trends in the prevalence of dyslipidemia in Germany and in an international comparison. An English full-text version of this article is available at SpringerLink as supplemental.

[Prevalence of hysterectomy in women 18 to 79 years old: results of the German Health Interview and Examination Survey for Adults (DEGS1)]. / Prävalenz von Hysterektomien bei Frauen im Alter von 18 bis 79 Jahren: Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1).

In many countries, hysterectomy is one of the most frequently performed surgical procedures in gynaecology. The aim of this study is to analyse the prevalence of hysterectomy in Germany by socio-demographic factors and factors of (reproductive) health. Analyses are based on data from the "German Health Interview and Examination Survey for Adults (DEGS1)", which is part of the health monitoring of the Robert Koch Institute (RKI). The prevalence of hysterectomy among participating women (18-79 years old) was 17.5% (n = 689). Most women (49.1%) were 40-49 years old when surgery was performed. 6.1% of hysterectomised women had cancer of the uterus or ovaries, and 19.7% underwent a simultaneous oophorectomy. There were significant differences in the prevalence of hysterectomy regarding social status, place of residence in 1988, number of live births, and body weight. DEGS1 is the first study showing the prevalence of hysterectomy in a representative sample of the German population. More detailed analyses of the DEGS data, among other data sources, are needed to evaluate the importance of the described associations and to assess trends. An English full-text version of this article is available at SpringerLink as supplemental.

[Medication use of adults in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)]. / Arzneimittelanwendung von Erwachsenen in Deutschland : Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1).

The first wave of the German Health Interview and Examination Survey for Adults, 2008-2011 (DEGS1), assesses current medicine use among participating adults aged 18-79 years in the 7 days prior to the medical examination as part of a standardised interview. About three quarters (74.4 %) of all men and women state that they used at least one preparation. Prevalence is highest among 70-79 year olds (men 94.9 %; women 96.3 %). Overall women have a significantly higher prevalence rate (85.4 %) than men (63.8 %). Preparations for the treatment of cardiovascular diseases are the most frequently used medicines (men 27.2 %; women 29.5 %). Polypharmacy (the use of 5 or more preparations) increases continuously with age and is observed significantly more often in women than in men in all age groups with the exception of the age group 70-79. Of the 20,084 recorded preparations, 71.8 % are prescribed by a doctor and 27.7 % are self-medicated. While there are no differences in overall medication linked to social status, a social gradient is observed in prescribed preparations and self-medication. The results presented here describe key indicators of medication use representative of the German adult population. Based on the extensive data of DEGS1, further analyses into aspects such as co- and multimedication will be addressed in the future. An English full-text version of this article is available at SpringerLink as supplemental.

[Hydronephrosis after suburethral sling implantation: diagnosis and operative management in men]. / Harnstauungsniere nach suburethraler Bandeinlage : Diagnostik und operatives Management beim Mann.

Readjustable suburethral sling procedures have become established as a standard method for therapy of postoperative urinary stress incontinence in men. Due to the silicone construction revision after implantation of Argus ™ slings can be carried out without problems even after a long indwell time. In the case presented correction of sling-related hydronephrosis due to incorrect positioning of the Argus ™ sling is demonstrated. Surgical correction was possible without explantation or exchanging the system and ensuring a good functional outcome.

[Possibilites and limitations of retrospective research on cause of death within the framework of a nationwide epidemiological study]. / Möglichkeiten und Grenzen retrospektiver Todesursachenrecherchen im Rahmen bundesweiter epidemiologischer Studien.

Cause-specific mortality is an important endpoint in longitudinal epidemiological studies to research causal health links and carry out individual process analyses. As in Germany no national mortality register exists, state-specific data-protection conditions for and approaches to cause of death studies were researched and tested within the framework of a pilot project. The database was provided by a sample of deceased study participants from the 1998 nationwide health survey. Under the given conditions, cause of death research in a nationwide epidemiological study is possible in principle, but requires a great deal of time and effort. In Rhineland-Palatinate research needs to be carried out in a timely manner as the health authorities' retention period for death certificates is limited to minimum of 5 years. In Berlin the research situation is particularly difficult as, while the death certificates are held 3 years by the statistics bureau, this department cannot release any pseudonymous data. In Berlin it is possible to research the cause of death for some of the deceased through the doctors and hospitals that issued the death certificates and through the GKR Berlin-Brandenburg (in keeping with the special data protection measures of the cancer registry). In North Rhine Westphalia the written consent obtained during people's lifetimes, including an explicit release from medical confidentiality, is required to carry out cause of death research. In all other German states exceptions are possible, in all cases requiring the consent of the state's data protection commissioners. The results of the pilot project underline the need for a national mortality register. Until this is established the approach used in the pilot study can be used and, working together with the state and national data protection authorities and with the highest national health authorities, can be further optimized in order to avoid losing data and to use resources efficiently.

Analgesic use in a national community sample of German children and adolescents.

BACKGROUND: Previous studies suggest that pain management by analgesic medications may be low among children. This study aims to investigate analgesic use and its correlates among children in Germany. METHODS: Analgesic use during a 1-week period was investigated in a community sample of 14,836 children and adolescents aged between 3 and 17 years in Germany. SPSS complex sample method was used to estimate the prevalence and associated factors of analgesic use among the general child population and among those children with pain in the same child population. RESULTS: The prevalence of analgesic use was 8.9% among the general child population and 17.5% among children with pain that occurred at least once a week. Paracetamol (acetaminophen), aspirin and ibuprofen were the most frequently used paediatric analgesics, accounting for two-thirds of all analgesics. The vast majority of painkillers were self-medicated (67%, bought over the counter or obtained from other sources), used for a short term within 1 week (92%) and taken for the treatment of pain (85%). Use of analgesics was closely associated with girls, older age groups, children with a poor overall health status and children with recurrent pain, irrespective of family immigrant background and socioeconomic status. CONCLUSION: Analgesic use appears to be low among children in Germany, reflecting largely the fact that pain perceived among children under ambulant care may be mild to moderate and does not need analgesic medications. As the majority of paediatric analgesics were self-medicated, use of analgesics still should be closely monitored particularly among specific subpopulations such as adolescents to avoid potential abuse.

[Sticking guide wire. Problems with a high-flow catheter]. / "Der Draht hakt". Probleme mit einem "High-flow"-Katheter.

In the case presented an intravenous line for large volume infusion rates was to be placed in a patient with an aortic aneurysm during clinical preoperative care. After a high-flow catheter had been placed without any problems retraction of the guide wire was found to be impossible. Computer tomography revealed that the reason was a kink in the catheter resulting in the guide wire being nipped off. Fortunately both catheter and guide wire could be removed completely without any further complications.

Psychotropic medication in children and adolescents in Germany: prevalence, indications, and psychopathological patterns.

OBJECTIVE: The aim of this study was to identify the "real-life" prevalence of psychotropic medications in children and adolescents in Germany and related behavioral and emotional problems. Data from the nationwide representative National German Health Interview and Examination Survey for Children and Adolescents (KiGGS) were analyzed. METHOD: A total of 17,450 subjects aged 0-17 years from 167 communities were examined as part of the KiGGS in Germany between 2003 and 2006 to determine their use of antidepressants, antipsychotics, anxiolytics, and sedatives within the 7 days prior to being interviewed. Medication use was assessed by a medical doctor who conducted a computer-assisted personal interview (CAPI) with the parents, and related emotional and behavioral problems were assessed using the Strength and Difficulties Questionnaire (SDQ). RESULTS: The overall prevalence for these medications was moderate (4.81/1000; 95% confidence interval [CI], 3.70-6.26), but prevalence varied across the different classes of drugs (sedatives > antipsychotics > antidepressants > anxiolytics). Rates of off-label use were high for antipsychotics and antidepressants. About 30% of the medication, especially sedatives, was used without prescription. Subjects using psychotropic medication obtained higher scores in the screening for emotional or behavioral problems than the total sample, but 40% of the children did not show abnormal scores. CONCLUSION: The indication for antipsychotics was mostly behavioral symptomatology, while antidepressants were used for a wide variety of symptoms. The high proportion of children and adolescents using psychotropic medication with normal scores in the emotional and behavioral screening was remarkable. It cannot be determined whether in these cases low scores were related to improvement in symptoms or whether medication was being misused.

Health correlates and mode of administration of hormones--are there any differences between parenteral and oral estrogen preparations?

OBJECTIVES: To investigate use-associated differences between parental and oral hormone therapy (HT) users in reference to HT non-users regarding self-rated general health status, quality of life, health service utilization, and selected chronic diseases. METHODS: All cases of last-week medicine use were recorded among 2248 women aged 40-79 who participated in the German Health Interview and Examination Survey 1997-1999. 89 current parenteral HT users and 322 oral HT users were identified. Health correlates were compared between the two groups in reference to HT non-users. RESULTS: Oral HT users had a poorer current health status as well as an impaired health status compared to the year before, were less satisfied with their health and life in general, and showed a lower quality of life regarding 'body pain' and 'vitality' in comparison with hormone non-users (all p<.05). Parenteral HT users showed no significant difference compared with HT non-users and oral HT users, respectively, in these health correlates except for a less satisfaction with health found in comparison with HT non-users (p=.002). Prevalences of cerebral-cardiovascular diseases were not different among women using parenteral or oral HT use. Parenteral HT users visited the offices of general practitioner and gynecologists more frequently than oral HT users as well as hormone non-users (all p<.05). CONCLUSIONS: Oral HT use is associated with a negative assessment for health well-being whereas parenteral HT use shows largely a neutral effect. Further designated studies could clarify whether the mode of hormone administration consistently affects health-related quality of life and whether the mode of hormone treatment influences the choice of outpatient facilities for surveillance of therapy.

Changes of menopausal hormone therapy use pattern since 2000: results of the Berlin Spandau Longitudinal Health Study.

BACKGROUND: There are virtually no prospective cohort studies in Germany regarding the changes of menopausal hormone therapy (HT) use pattern and factors associated with HT discontinuation after the release of the Women's Health Initiative (WHI) trial results. METHODS: We assessed HT prevalence and use pattern as well as factors associated with HT discontinuation in a cohort of 903 women 40 years of age and older, who participated in two consecutive follow-up visits in a 20-year prospective health study from July 2000 to February and from August 2002 to December 2004. RESULTS: Overall, the prevalence of HT users in the cohort declined significantly from 35.4% in 2000-2002 to 22.5% in 2002-2004. Adjusting for aging of the population, a statistically significant decrease in HT user prevalence was consistently observed across subgroups of HT users defined by type and duration of HT use. The decline was most pronounced with respect to women using combined estrogen-progestin regimens (-10.5%), higher-dose estrogens (-11.6%), oral preparations (-11.1%), as well as long-term HT users (-8.4%). The prevalence of women indicating HT use for climacteric symptoms decreased significantly (-12.4%), whereas the prevalence of women reporting use of HT for the prevention of osteoporosis increased (+1.8%) significantly. Irrespective of hysterectomy status, half of the women who continued HT changed their HT preparations and switched to lower estrogen doses (11.5%), topical estrogens (8.2%), or phytohormones (3.8%). We did not observe any significant differences between women who continued and discontinued HT regarding health-related characteristics of the study population as of 2000-2002. However, women seeing a gynecologist in the 12 months preceding the 2002-2004 visit were significantly less likely to discontinue HT use in bivariate and multivariate analyses. CONCLUSIONS: Substantial declines in HT user prevalence as well as changes in HT use patterns to lower-dose estrogen preparations and non-oral routes of administration are likely to reflect effects of the publication of the WHI results. Consulting a gynecologist appeared to be relevant for a woman's decision to continue HT.

Use of psychotropic drugs and alcohol among non-institutionalised elderly adults in Germany.

INTRODUCTION: Little is known about the use of psychotropic drugs and alcohol among non-institutionalised elderly adults in Germany. METHODS: Using data from the 1998 German National Health Interview and Examination Survey, we analysed patterns of current psychotropic drug and alcohol use among 726 male and 879 female survey participants between the ages of 60 and 79. Multivariable regression analysis was used to determine factors associated with alcohol consumption and psychotropic drug use. RESULTS: The overall weighted last-week prevalence was 20.1% for the use of psychotropic drugs, 47.3% for the use of alcohol, 15.1% for risky drinking, and 7.6% for combined psychotropic drug and alcohol use. Factors significantly related to psychotropic drug use included female sex, older age, poor health status and polypharmacy. Male sex, smoking, higher social status, better health status and living alone were determinants of alcohol consumption. CONCLUSIONS: Compared to other European countries, overall psychotropic drug use among the elderly in Germany is slightly lower, whereas alcohol use as risky drinking and concurrent use of alcohol and psychotropic drugs are highly prevalent. It should be of particular concern to health professionals that people at high risk for psychotropic drug use include the most vulnerable subgroups among the elderly.