RESUMO
[formula: see text] The first total synthesis of spicamycin amino nucleoside 2 has been achieved. The aminoheptose unit 5 was prepared stereoselectively from myo-inositol, and the characteristic N-glycoside linkage was constructed by way of Pd-catalyzed coupling reaction of 5 with 6-chloropurine derivative 6.
Assuntos
Inositol/química , Espectroscopia de Ressonância Magnética , Paládio/química , Nucleosídeos de Purina/síntese química , Nucleosídeos de Purina/químicaRESUMO
We semiquantitatively analyzed expression of PCNA and LeY in seborrheic keratosis (SK), actinic keratosis (AK), Bowen's disease (BD), and squamous cell carcinoma (SCC), using immunocytochemically stained tissue sections. PCNA expression increased in a stepwise fashion from low levels in normal skin to higher expressions within SK, AK, BD, and SCC. The levels of LeY protein also increased in this order. The PCNA expression pattern shifted from expression limited to the basal and suprabasal cell layers (in normal skin and SK) to expression extending to the upper squamous and granular layers (in AK, BD, and SCC). On the other hand, the pattern of LeY expression shifted from the granular (in normal skin) to the upper squamous (in SK and AK) and suprabasal layers (in BD and SCC). These findings suggest that PCNA expression is related to the degree of cell proliferation and that LeY expression is related to the degree of differentiation or keratinization of tumor cells. In addition, PCNA and LeY show a reciprocal relationship in their expression.
Assuntos
Antígenos do Grupo Sanguíneo de Lewis/metabolismo , Antígeno Nuclear de Célula em Proliferação/metabolismo , Neoplasias Cutâneas/metabolismo , Doença de Bowen/metabolismo , Carcinoma in Situ/metabolismo , Carcinoma de Células Escamosas/metabolismo , Humanos , Imuno-Histoquímica , Ceratose Seborreica/metabolismoRESUMO
BACKGROUND: Perianal Paget's disease often coincides with anorectal carcinoma, which extends into the epidermis from a contiguous organ. OBJECTIVE: Our purpose was to present a patient with perianal Paget's disease who had a rectal adenocarcinoma excised 14 years previously in another hospital and to determine whether there is a relationship between the perianal Paget's disease and the rectal adenocarcinoma. METHODS: We examined the resected specimens of the rectal adenocarcinoma and the perianal Paget's disease histologically. RESULTS: In the resected specimen of the rectal adenocarcinoma, Paget cells were present within the anal epidermis adjacent to the rectal adenocarcinoma. The Paget cells showed the same histochemical and immunohistological findings as the adenocarcinoma cells. CONCLUSION: There was a close relationship between the perianal Paget's disease and the rectal adenocarcinoma. It is probable that the Paget cells were derived from direct spread from the rectal adenocarcinoma.
Assuntos
Adenocarcinoma/patologia , Neoplasias das Glândulas Anais/patologia , Doença de Paget Extramamária/patologia , Neoplasias Retais/patologia , Adenocarcinoma/metabolismo , Adenocarcinoma/cirurgia , Neoplasias das Glândulas Anais/etiologia , Neoplasias das Glândulas Anais/metabolismo , Animais , Antígeno CA-19-9/metabolismo , Antígeno Carcinoembrionário/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Mucina-1/metabolismo , Doença de Paget Extramamária/etiologia , Doença de Paget Extramamária/metabolismo , Reação do Ácido Periódico de Schiff , Neoplasias Retais/metabolismo , Neoplasias Retais/cirurgiaRESUMO
A 54-year-old Japanese man with ulcerative lichen planus is reported. He had a painful erythema with ulcers on his soles and nail dystrophy. Mucous involvement was present on his lip. His hairs were intact. Histopathological findings confirmed the diagnosis of lichen planus.
