RESUMO
Contents of free amino acids and some biogenic amines were studied in hypertonic patients at the age of 40-50 years. The study demonstrates quantitative changes in levels of free amino acids and some biogenic amines caused by disorders of protein metabolism. The data obtained may be used for diagnosis of hypertonic diseases.
Assuntos
Aminoácidos/urina , Aminas Biogênicas/urina , Hipertensão/urina , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Caracteres SexuaisRESUMO
It was established that initial stages of hypertensive disease are accompanied by quantitative changes of the content of free fatty acids. An important diagnostic criterion in the pathogenesis of this disease are unsaturated fatty acids. Their concentration was studied in erythrocytes using gaseous-fluid chromatography. Dynamic examination of fatty acid composition is informative in different forms of cardiovascular diseases.
Assuntos
Ácidos Graxos não Esterificados/sangue , Hipertensão/sangue , Adulto , Cromatografia Gasosa , Membrana Eritrocítica/química , Feminino , Humanos , Masculino , Lipídeos de Membrana/análiseRESUMO
Blood plasma and red cell membrane levels of polyunsaturated fatty acids were measured by gas chromatography in patients with Stage I essential hypertension, borderline arterial hypertension, functional classes II-IV unstable angina pectoris, and unstable angina. The findings suggest that insufficient linolenic acid level in blood plasma and red cell membranes and, in the majority of cases, elevated concentrations of linoleic acid are among lipid metabolism disorders in cardiovascular patients. This fact permits a conclusion that measurements of blood plasma and red cell membrane levels of polyunsaturated fatty acids may be an additional diagnostic criterion permitting an assessment of the disease severity and elucidation of the pathogenesis of coronary disease and arterial hypertension.