RESUMO
In pharmacological ulcer models in rats colloidal bismuth subcitrate (CBS) demonstrated anti-ulcer activity. This was neither a result of an acid neutralizing nor of an acid secretion inhibitory effect. Both in vitro and in vivo, an anti-peptic action was found. At low pH CBS precipitates and was shown to form a coating on the gastric wall especially on the ulcer crater. This coating most likely forms a protective barrier to the peptic activity of gastric juice. Low toxicity was seen following chronic daily administration of high doses of CBS for 3 months to rats and 6 months to dogs. Although the blood levels were more elevated in rats, the tissue bismuth levels were comparable in the two species (except for the caecum). The chief bismuth-excreting organs, the kidneys, showed relatively high concentrations, while the brain-concentrations were extremely low in concordance with the absence of nervous system toxicity.
Assuntos
Antiulcerosos/farmacologia , Bismuto/farmacologia , Compostos Organometálicos , Animais , Bismuto/metabolismo , Fenômenos Químicos , Química , Coloides , Modelos Animais de Doenças , Ácido Gástrico , Ratos , Fatores de TempoRESUMO
The anti-ulcer action of colloidal bismuth subcitrate (CBS) was tested in rats with a ligated pylorus (the Shay preparation). The liquid form used in the clinic displayed a dose-related inhibition of gastric ulceration. the recently developed solid form appeared to be just as effective. On the other hand, non-processed, non-colloidal bismuth salts and the CBS vehicle blank were completely inactive. The anti-ulcer activity of CBS was found to be unrelated to its buffering capacity.
