Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 12 de 12
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Ned Tijdschr Geneeskd ; 150(52): 2876-9, 2006 Dec 30.
Artigo em Holandês | MEDLINE | ID: mdl-17319221

RESUMO

A 17-year-old boy who had already undergone appendectomy, presented with a one-day history of severe pain in his right lower abdomen. Physical examination and other investigations indicated acute appendicitis. On exploratory laparotomy, a second, inflamed appendix was found. Appendectomy was carried out, and the patient made a good recovery. Pathological examination of the organs removed at each operation confirmed that during both procedures an intact and clearly inflamed appendix had been removed. A double appendix is a rare clinical entity and may be associated with other congenital abnormalities. Doctors should be aware of the possibility of appendiceal duplication to avoid delay in diagnosis and treatment.


Assuntos
Apendicectomia , Apendicite/diagnóstico , Apêndice/anormalidades , Apêndice/cirurgia , Adolescente , Apendicite/cirurgia , Humanos , Masculino , Recidiva , Resultado do Tratamento
2.
Clin Infect Dis ; 31(3): 841-2, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11017847

RESUMO

Tuberculous aortitis with a tuberculous mycotic aneurysm and an aortoduodenal fistula was diagnosed in a 38-year-old man with tuberculous cervical lymphadentitis and a 3-month history of recurrent gastrointestinal bleeding, in whom extensive investigation of the digestive tract had not revealed a bleeding lesion. Either by septic embolism or by direct extension from a neighboring focus, tuberculous infection can cause a mycotic aortic aneurysm with subsequent fistulation to the duodenum.


Assuntos
Aortite/patologia , Hemorragia Gastrointestinal/patologia , Fístula Intestinal/patologia , Tuberculose Cardiovascular/patologia , Fístula Vascular/patologia , Adulto , Aortite/complicações , Hemorragia Gastrointestinal/etiologia , Humanos , Fístula Intestinal/complicações , Masculino , Recidiva , Tuberculose Cardiovascular/complicações , Fístula Vascular/complicações
3.
Ann Thorac Surg ; 69(6): 1928-9, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10892949

RESUMO

We report a case of a large symptomatic angioleiomyoma of the diaphragm. The tumor was diagnosed by computed tomography and videothoracoscopic biopsy. We removed the tumor through a left thoracolaparotomy. Three months later, a local recurrence was removed through an upper midline laparotomy. The patient remains without evidence of a recurrence 48 months after the second operation.


Assuntos
Angiomioma/cirurgia , Diafragma/cirurgia , Neoplasias Musculares/cirurgia , Neoplasias Torácicas/cirurgia , Angiomioma/patologia , Diafragma/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Musculares/patologia , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/cirurgia , Complicações Pós-Operatórias/patologia , Complicações Pós-Operatórias/cirurgia , Reoperação , Neoplasias Torácicas/patologia , Toracotomia , Tomografia Computadorizada por Raios X
4.
Acta Obstet Gynecol Scand ; 75(4): 400-3, 1996 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8638464

RESUMO

BACKGROUND: To determine whether interval carcinomas occurred and to determine the level of screening-participation by women who developed a cervical carcinoma. METHODS: A retrospective study of the cytological history of 469 patients diagnosed between January 1980 and December 1989 with cervical squamous cell carcinoma in 12 hospitals in the western part of The Netherlands. Clinical data, and cervical smear histories in 3.5 years preceding the diagnoses were obtained. Cervical smears diagnosed as Pap I, II or IIIA were traced for review. RESULTS: 306 patients' data were completed. Two hundred and twenty-three patients (72.9%) had never been screened and 83 patients (27.1%) had had at least one smear, of which 39 were normal. The percentage of women over 54 was higher in patients who had never been screened (58%) than in those screened (46%). Women over 54 were in higher Figo stage. Interval carcinoma was proven in six of 306 (2%) patients. Of the normal smears 53% were false negative. CONCLUSION: The high number of non-participants still forms the main reason for the failure of cervical cancer screening. Secondly, the assumed existence of frequent interval carcinoma could not be demonstrated. There are grounds for changing the age limits of the current Dutch screening program without changing the screening interval.


Assuntos
Carcinoma de Células Escamosas/epidemiologia , Neoplasias do Colo do Útero/epidemiologia , Adulto , Fatores Etários , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Feminino , Registros Hospitalares , Humanos , Programas de Rastreamento , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Países Baixos/epidemiologia , Estudos Retrospectivos , Fatores de Tempo , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/patologia , Esfregaço Vaginal
5.
Cytopathology ; 5(6): 359-68, 1994 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7880969

RESUMO

Fourteen percutaneous fine needle aspirates (FNAs) of focal liver lesions performed under ultrasound guidance at the Sultan Qaboos University Hospital (SQUH), Oman, between January 1991 and October 1992, are presented. Ten of these were cytologically diagnosed as hepatocellular carcinomas (HCC). The patients' ages ranged from 50 to 70 years and eight of these were males. The important diagnostic cytological criteria of HCC were found to be increased nucleocytoplasmic (N/C) ratio, trabecular pattern, atypical naked nuclei, bile production by malignant hepatocytes and absence of bile duct epithelium. Carcinoembryonic antigen (CEA) positivity of bile canaliculi by cross-reaction with biliary glycoprotein I (BGP I) made possible the differentiation of HCC from metastases. We stress the importance of cell blocks as these often constitute microbiopsies. Ultrasound-guided FNA of focal liver lesions is recommended as a simple, easy and quick procedure.


Assuntos
Carcinoma Hepatocelular/patologia , Neoplasias Hepáticas/patologia , Idoso , Antígenos CD , Biópsia por Agulha , Antígeno Carcinoembrionário/análise , Carcinoma Hepatocelular/química , Moléculas de Adesão Celular , Feminino , Glicoproteínas/análise , Humanos , Imuno-Histoquímica , Neoplasias Hepáticas/química , Masculino , Pessoa de Meia-Idade , Ultrassom
6.
Cancer ; 67(12): 3123-6, 1991 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-2044055

RESUMO

After antileukemic chemotherapy a granulocytopenic patient experienced a rapidly progressive left-sided pneumonia with pleuritic pain. After 1 week, a sudden occlusion of all aortic branches was followed by death. At postmortem, a huge thrombus in the aortic arch caused by Aspergillus invasion from the left lung was found.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doenças da Aorta/patologia , Aspergilose/patologia , Leucemia/tratamento farmacológico , Pneumopatias Fúngicas/patologia , Trombose/patologia , Adulto , Aorta Torácica/patologia , Humanos , Masculino
7.
J Infect ; 18(3): 283-8, 1989 May.
Artigo em Inglês | MEDLINE | ID: mdl-2663999

RESUMO

A 46-year-old patient with acute myelogenous leukaemia developed lethal disseminated toxoplasmosis 8 weeks after allogeneic bone marrow transplantation. Clinical features included pulmonary infiltrates, respiratory insufficiency and neurological signs. Post-transplantation toxoplasma serological tests were characterised by declining IgG titres and failure to detect IgM, whereas titres of IgG against the various herpes viruses remained constant and even increased over the same period. Circulating toxoplasma antigen could not be detected. Post mortem, specific immune complexes were identified in serum. Autopsy revealed widely disseminated toxoplasmosis with several foci in the brain, lungs and various other organs as well as concomitant infection with cytomegalovirus.


Assuntos
Anticorpos Antiprotozoários/análise , Transplante de Medula Óssea , Leucemia Mieloide Aguda/cirurgia , Toxoplasma/imunologia , Toxoplasmose/diagnóstico , Animais , Ciclosporinas/uso terapêutico , Humanos , Imunoglobulina G/análise , Imunoglobulina M/análise , Leucemia Mieloide Aguda/complicações , Masculino , Pessoa de Meia-Idade , Toxoplasmose/complicações , Toxoplasmose/imunologia
8.
Am J Clin Pathol ; 90(4): 391-6, 1988 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-2459953

RESUMO

A comparative immunohistologic and immunocytologic study was performed to assess the immunoreactivity of the monoclonal antibodies OC125 and OV632, both directed at antigens present on epithelial ovarian tumors. OC125 reacted with 53 of 59 ovarian carcinomas, 20 of 20 uterine carcinomas, and 25 of 111 nongynecologic tumors (including 20 of 38 breast carcinomas). OV632 was demonstrated in 47 of 59 ovarian carcinomas, 11 of 20 uterine carcinomas, and only 7 of 111 nongynecologic tumors. With OV632 no reactivity was found in carcinomas of the breast or the gastrointestinal tract. Cytologic preparations of malignant effusions of patients with ovarian cancer showed reactivity with OC125 in 32 of 35 cases, and OV632 with positivity in 34 of 35 cases. Mesothelial cells in reactive effusions were OC125 positive in 16 of 20 cases but never showed positivity with OV632. The authors conclude that for histopathology a combination of OC125 and OV632 offers high sensitivity (0.86) and specificity (0.89) for ovarian cancer. For cytology, OV632 is the most specific tumor marker available.


Assuntos
Anticorpos Monoclonais , Biomarcadores Tumorais , Imuno-Histoquímica , Neoplasias Ovarianas/patologia , Coloração e Rotulagem , Especificidade de Anticorpos , Reações Antígeno-Anticorpo , Líquido Ascítico/análise , Líquido Ascítico/patologia , Feminino , Humanos , Imuno-Histoquímica/métodos , Neoplasias Ovarianas/análise , Coloração e Rotulagem/métodos
9.
Acta Cytol ; 32(5): 707-12, 1988.
Artigo em Inglês | MEDLINE | ID: mdl-2458662

RESUMO

The value of monoclonal antibodies (MAbs) for the immunodetection of keratin, vimentin and two melanoma-associated antigens recognized by NKI/C3 and NKI/Bteb for the diagnosis of malignant melanoma has been previously established on histologic preparations. In the present study, cytologic preparations from 20 fine needle aspirates and effusions from patients with malignant melanoma were evaluated using these antibodies. Twenty of 20 smears were negative for keratin, and 20 of 20 smears were positive for vimentin. Positivity for NKI/C3 was seen in 12 of 12 cases studied, and for NKI/Bteb in 12 of 13 cases. These results indicate that a panel of MAbs consisting of anti-keratin, anti-vimentin, NKI/C3 and NKI/Bteb is useful for a more accurate diagnosis of malignant melanomas on cytologic preparations. The expression of these antigens in melanoma cells in cytologic smears can be a valuable aid in the detection of primary (noncutaneous) and metastatic melanomas by fine needle aspiration.


Assuntos
Anticorpos Monoclonais , Melanoma/diagnóstico , Antígenos de Neoplasias/análise , Biópsia por Agulha , Humanos , Técnicas Imunoenzimáticas , Imuno-Histoquímica , Queratinas/análise , Melanoma/análise , Melanoma/patologia , Vimentina/análise
10.
Arch Pathol Lab Med ; 112(2): 151-4, 1988 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-3276289

RESUMO

The monoclonal antibody RAP 5 immunoreactive with the ras gene product p21 was used in an immunohistochemical study of 57 patients with advanced ovarian cancer and in 28 normal ovaries. The pattern of the staining of various tumor specimens was similar to the germinal epithelium of normal ovaries, whereas the intensity of staining was more enhanced in carcinomas than in normal ovaries. However, we found a lack of correlation among staining intensity of RAP 5 and the histologic type, the histologic grade, the ploidy class, and the clinical outcome.


Assuntos
Genes ras , Neoplasias Ovarianas/genética , Adenoma/genética , Adenoma/patologia , Adulto , Idoso , Anticorpos Monoclonais , Cistadenocarcinoma/genética , Cistadenocarcinoma/patologia , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Neoplasias Ovarianas/mortalidade , Neoplasias Ovarianas/patologia , Ovário/patologia , Ploidias
11.
Histopathology ; 11(3): 287-94, 1987 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-3480871

RESUMO

CA 125 is a tumour marker located primarily on non-mucinous epithelial ovarian tumours and which is recognized by the monoclonal antibody OC 125. In this study the value of CA 125 in surgical pathology was assessed. In fresh frozen material, the expression of CA 125 was demonstrated in 82% of 83 epithelial ovarian neoplasms using the indirect immunoperoxidase technique. In addition, all adenocarcinomas of cervix (n = 5) and endometrium (n = 15) tested expressed CA 125, and 25 of 111 (22%) non-gynaecological malignant tumours were positive. The positive cases included 20 breast carcinomas, one carcinoma of the stomach and one of the colon. Using a commercial kit on routinely fixed, paraffin embedded material, CA 125 positivity was demonstrated in 29 of 36 (80%) serous cystadenocarcinomas after pronase pre-treatment of the sections, in contrast to 100% (n = 25) positivity on frozen tissue sections. CA 125 can, therefore, be demonstrated in routinely fixed paraffin embedded material, although the number of positive results is less than in fresh frozen sections.


Assuntos
Antígenos de Neoplasias , Carcinoma/diagnóstico , Neoplasias Ovarianas/diagnóstico , Antígenos de Neoplasias/análise , Antígenos Glicosídicos Associados a Tumores , Carcinoma/análise , Feminino , Humanos , Imuno-Histoquímica , Proteínas de Neoplasias/análise , Neoplasias Ovarianas/análise
12.
Arch Pathol Lab Med ; 110(11): 1035-40, 1986 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-2430547

RESUMO

For the evaluation of differential diagnostic parameters, hepatocellular carcinoma (HCC, n = 26), liver cell adenoma (n = 4), focal nodular hyperplasia (n = 8), and secondary liver tumors (n = 15) were studied with histologic and immunohistochemical methods. The study was performed on formalin-fixed, paraffin-embedded tissue sections, and, in some cases, also on frozen sections. The diagnostic contribution of the demonstration of alpha-fetoprotein, alpha-antitrypsin, hepatitis B surface antigen, carcinoembryonic antigen (CEA), and biliary glycoprotein I (BGPI), compared with routine hematoxylin-eosin and reticulin stains was evaluated. For the differentiation between HCC, adenoma, and focal nodular hyperplasia, immunohistochemistry contributed less than the strict application of histologic criteria. Immunohistochemistry of CEA and BGPI, however, appeared to be of help in differentiating between primary and secondary liver tumors as follows: CEA is consistently absent in liver cell tumors, while a bile canalicular staining pattern was seen in 80% of HCC due to the presence of BGPI reactivity.


Assuntos
Adenoma/patologia , Carcinoma Hepatocelular/patologia , Neoplasias Hepáticas/patologia , Adenoma/imunologia , Antígenos CD , Antígenos de Neoplasias/análise , Antígeno Carcinoembrionário/análise , Carcinoma Hepatocelular/imunologia , Moléculas de Adesão Celular , Diagnóstico Diferencial , Glicoproteínas/análise , Antígenos de Superfície da Hepatite B/análise , Humanos , Hiperplasia/imunologia , Hiperplasia/patologia , Cirrose Hepática/patologia , Neoplasias Hepáticas/imunologia , alfa 1-Antitripsina/análise , alfa-Fetoproteínas/análise
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...