Dependência funcional e qualidade de vida relacionada à saúde bucal em uma coorte de 15 anos com pessoas idosas: um estudo caso-controle / Functional dependency and oral health-related quality of life in a 15-year cohort of older adults: a case-control study

Resumo Objetivo investigar a relação entre o aumento da dependência funcional e a deterioração da qualidade de vida relacionada à saúde bucal (QVRSB) em pessoas idosas decorridos 15 anos. Método Trata-se de um estudo caso-controle aninhado em uma coorte de pessoas idosas seguidas durante 15 anos proveniente do Estudo SABE (Saúde, Bem-estar e Envelhecimento). A QVRSB foi medida por meio do Geriatric Oral Health Assessment Index (GOHAI) nos anos 2000 e 2015. O desfecho foi determinado pelos participantes que passaram a relatar QVRSB insatisfatória, definida pelo escore ≤50, após 15 anos. As exposições foram condições sociodemográficas, condições gerais de vida e variáveis clínicas. Regressão Logística foi utilizada na análise dos dados. Resultados Dos indivíduos da coorte que avaliaram sua QVRSB como satisfatória/regular no ano 2000, foram identificados 53 casos que passaram a avaliar como insatisfatória e 194 controles que mantiveram sua qualidade de vida no ano 2015. A média de idade da coorte em 2015 foi 82,6 anos; 68,1% eram mulheres. Mudanças negativas na dependência funcional em atividades instrumentais (OR=2,50 IC95% 1,05-6,01; p=0,039), no número de dentes (OR=3,96 IC95% 0,99-15,83; p=0,052) e na renda insuficiente (OR=3,52 IC95% 0,94-13,18; p=0,061) mostraram associação com o desfecho. Conclusão Concluiu-se que a piora da dependência funcional em atividades instrumentais foi importante indicador de risco para a deterioração da QVRSB na população idosa mesmo na presença do aumento de dentes ausentes e da renda insuficiente, mostrando a importância de considerar outros fatores, além de variáveis clínicas e socioeconômicas, para o melhor entendimento da QVRSB.

Abstract Objective to investigate the relationship between the increase in functional dependence and the deterioration of oral health-related quality of life (OHRQoL) in older people after 15 years. Method This is a case-control study nested in a cohort of elderly people followed for 15 years from the SABE Study (Health, Wellbeing and Aging). OHRQoL was measured using the Geriatric Oral Health Assessment Index (GOHAI) in the years 2000 and 2015. The outcome was determined by participants who began to report unsatisfactory OHRQOL, defined by a score ≤50, after 15 years. Exposures were sociodemographic conditions, general living conditions and clinical variables. Logistic regression was used in data analysis. Results Out of cohort participants who assessed their OHRQOL as satisfactory/regular in the year 2000, 53 individuals that assessed as unsatisfactory were considered cases and 194 that maintained their OHRQOL were controls in the year 2015. The average age of the cohort in 2015 was 82.6 years; 68.1% were women. Negative changes in functional dependence on instrumental activities (OR=2.50 CI95% 1.05-6.01; p=0.039), number of teeth (OR=3.96 CI95% 0.99-15.83; p=0.052) and insufficient income (OR=3.52 CI95% 0.94-13,18; p=0.061) showed an association with the outcome. Conclusion It was concluded that worsening of functional dependence on instrumental activities was an important risk indicator for deterioration of OHRQoL in elderly people even in the presence of increase of both lost teeth and insufficient income, showing the importance of considering other factors, in addition to clinical and socioeconomic variables, for a better understanding of OHRQoL.

Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches.

Periodontitis is a high prevalent disease into the clinical dentistry. Genetic variations in interleukins (IL) genes were associated with chronic periodontitis (CP) and were focus of several meta-analyses. This study aimed to assess the noteworthiness in the meta-analyses by means of a Bayesian approach to determinate possible false report associations. A systematic search was performed for meta-analyses with associations between gene polymorphisms in interleukins and CP. The calculations for the False-Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. As results, eight meta-analyses approaching the IL1A/rs1800587, IL1B/rs1143634, IL1RN/rs2234663, IL4/rs2243250, IL6/rs1800795/rs1800796, IL17A/rs2275913 and IL18/rs1946518/rs187238 polymorphisms have been identified. Twenty-two from 270 calculations (8.15%) were noteworthy. Herein, we have identified the IL1A and IL1B polymorphisms as noteworthy biomarkers for CP susceptibility.

Non-significant association between - 330 T/G polymorphism in interleukin-2 gene and chronic periodontitis: findings from a meta-analysis.

BACKGROUND: Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data. METHODS: A literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I2) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg' and Egger's test with Comprehensive meta-analysis software. The value of P < 0.05 was considered as significant. RESULTS: Five studies were identified in diverse ethnical groups with 1425 participants. The - 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg's test and the linear regression Egger's test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic. CONCLUSIONS: This meta-analysis showed a non-significant association between - 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation.