Selective orthotic constraint of lower limb movement during walking reveals new insights into neuromuscular adaptation.

Introduction: A concern expressed by the clinical community is that the constraint of motion provided by an ankle foot orthosis (AFO) may lead the user to become dependent on its stiffness, leading to learned non-use. To examine this, we hypothesized that using an experimental AFO-footwear combination (exAFO-FC) that constrains ankle motion during walking would result in reduced soleus and tibialis anterior EMG compared to free (exAFO-FC) and control (no AFO, footwear only) conditions. Method: A total of 14 healthy subjects walked at their preferred speed (1.34 ± 0.09 m·s-1) for 15 min, in three conditions, namely, control, free, and stop. Results: During the stance phase of walking in the stop condition, ipsilateral soleus integrated EMG (iEMG) declined linearly, culminating in a 32.1% reduction compared to the control condition in the final 5 min interval of the protocol. In contrast, ipsilateral tibialis anterior iEMG declined in a variable fashion culminating in an 11.2% reduction compared to control in the final 5 min interval. During the swing phase, the tibialis anterior iEMG increased by 6.6% compared to the control condition during the final 5 min interval. The contralateral soleus and tibialis anterior exhibited increased iEMG in the stop condition. Discussion: An AFO-FC functions as a biomechanical motion control device that influences the neural control system and alters the output of muscles experiencing constraints of motion.

Material properties and application of biomechanical principles provide significant motion control performance in experimental ankle foot orthosis-footwear combination.

BACKGROUND: This study, the first of its kind, originated with the need for a brace (an ankle foot orthosis), to constrain ankle plantarflexion and dorsiflexion within a motion threshold of <5°. A conventional thermoplastic, solid brace failed during a quasi-static loading study, informing the investigation and development of an experimental carbon composite brace, maximizing stiffness and proximity of shank and foot cylindrical shells to provide the required degree of control. METHODS: Two experiments were conducted: a quasi-static loading study, using cadaveric limbs (n = 2), and a gait study with healthy subjects (n = 14). Conditions tested were STOP, FREE, and CONTROL. Data for all studies were collected using six motion-capture cameras (Vicon, Oxford, UK; 120 Hz) tracking bone-anchored markers (cadaveric limbs) and skin-anchored markers (subjects). In the quasi-static loading study, loading conditions were congruent with the gait study. Study 1 involved a quasi-static loading analysis using cadaveric limbs, compared motion data from a conventional thermoplastic solid brace and the experimental brace. Study 2 involved quantifying ankle plantarflexion and dorsiflexion in subjects during treadmill walking, in brace STOP, FREE, and CONTROL conditions. FINDINGS: The experimental brace in STOP condition consistently constrained ankle plantarflexion and dorsiflexion below the motion threshold of <5°, across all studies. INTERPRETATION: Collectively, these findings demonstrate (1) that a conventional thermoplastic, solid brace was ineffective for clinical applications that required significant motion control, and (2) that ankle motion control is most effective when considered as a relationship between the brace, the ankle-foot complex, and the external forces that affect them both.

Acoustic Emissions as a Non-invasive Biomarker of the Structural Health of the Knee.

The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation. In this paper, we investigate that mechanism using an injury model in human lower-limb cadavers, and relate AEs to joint kinematics. Using our custom joint sound recording system, we recorded the AEs from nine cadaver legs in four stages: at baseline, after a sham surgery, after a meniscus tear, and post-meniscectomy. We compare the resulting AEs using their b-values. We then compare joint anatomy/kinematics to the AEs using the X-ray reconstruction of moving morphology (XROMM) technique. After the meniscus tear the number and amplitude of the AE peaks greatly increased from baseline and sham (b-value = 1.33 ± 0.15; p < 0.05). The XROMM analysis showed a close correlation between the minimal inter-joint distances (0.251 ± 0.082 cm during extension, 0.265 ± .003 during flexion, at 145°) and a large increase in the AEs. This work provides key insight into the nature of joint AEs, and details a novel technique and analysis for recording and interpreting these biosignals.

Acoustical Emission Analysis by Unsupervised Graph Mining: A Novel Biomarker of Knee Health Status.

OBJECTIVE: To study knee acoustical emission patterns in subjects with acute knee injury immediately following injury and several months after surgery and rehabilitation. METHODS: We employed an unsupervised graph mining algorithm to visualize heterogeneity of the high-dimensional acoustical emission data, and then to derive a quantitative metric capturing this heterogeneity-the graph community factor (GCF). A total of 42 subjects participated in the studies. Measurements were taken once each from 33 healthy subjects with no known previous knee injury, and twice each from 9 subjects with unilateral knee injury: first, within seven days of the injury, and second, 4-6 months after surgery when the subjects were determined to start functional activities. Acoustical signals were processed to extract time and frequency domain features from multiple time windows of the recordings from both knees, and k-nearest neighbor graphs were then constructed based on these features. RESULTS: The GCF calculated from these graphs was found to be 18.5 ± 3.5 for healthy subjects, 24.8 ± 4.4 (p = 0.01) for recently injured, and 16.5 ± 4.7 (p = 0.01) at 4-6 months recovery from surgery. CONCLUSION: The objective GCF scores changes were consistent with a medical professional's subjective evaluations and subjective functional scores of knee recovery. SIGNIFICANCE: Unsupervised graph mining to extract GCF from knee acoustical emissions provides a novel, objective, and quantitative biomarker of knee injury and recovery that can be incorporated with a wearable joint health system for use outside of clinical settings, and austere/under resourced conditions, to aid treatment/therapy.

Wearable knee health system employing novel physiological biomarkers.

Knee injuries and chronic disorders, such as arthritis, affect millions of Americans, leading to missed workdays and reduced quality of life. Currently, after an initial diagnosis, there are few quantitative technologies available to provide sensitive subclinical feedback to patients regarding improvements or setbacks to their knee health status; instead, most assessments are qualitative, relying on patient-reported symptoms, performance during functional tests, and physical examinations. Recent advances have been made with wearable technologies for assessing the health status of the knee (and potentially other joints) with the goal of facilitating personalized rehabilitation of injuries and care for chronic conditions. This review describes our progress in developing wearable sensing technologies that enable quantitative physiological measurements and interpretation of knee health status. Our sensing system enables longitudinal quantitative measurements of knee sounds, swelling, and activity context during clinical and field situations. Importantly, we leverage machine-learning algorithms to fuse the low-level signal and feature data of the measured time series waveforms into higher level metrics of joint health. This paper summarizes the engineering validation, baseline physiological experiments, and human subject studies-both cross-sectional and longitudinal-that demonstrate the efficacy of using such systems for robust knee joint health assessment. We envision our sensor system complementing and advancing present-day practices to reduce joint reinjury risk, to optimize rehabilitation recovery time for a quicker return to activity, and to reduce health care costs.

Novel Methods for Sensing Acoustical Emissions From the Knee for Wearable Joint Health Assessment.

OBJECTIVE: We present the framework for wearable joint rehabilitation assessment following musculoskeletal injury. We propose a multimodal sensing (i.e., contact based and airborne measurement of joint acoustic emission) system for at-home monitoring. METHODS: We used three types of microphones-electret, MEMS, and piezoelectric film microphones-to obtain joint sounds in healthy collegiate athletes during unloaded flexion/extension, and we evaluated the robustness of each microphone's measurements via: 1) signal quality and 2) within-day consistency. RESULTS: First, air microphones acquired higher quality signals than contact microphones (signal-to-noise-and-interference ratio of 11.7 and 12.4 dB for electret and MEMS, respectively, versus 8.4 dB for piezoelectric). Furthermore, air microphones measured similar acoustic signatures on the skin and 5 cm off the skin (∼4.5× smaller amplitude). Second, the main acoustic event during repetitive motions occurred at consistent joint angles (intra-class correlation coefficient ICC(1, 1) = 0.94 and ICC(1, k) = 0.99). Additionally, we found that this angular location was similar between right and left legs, with asymmetry observed in only a few individuals. CONCLUSION: We recommend using air microphones for wearable joint sound sensing; for practical implementation of contact microphones in a wearable device, interface noise must be reduced. Importantly, we show that airborne signals can be measured consistently and that healthy left and right knees often produce a similar pattern in acoustic emissions. SIGNIFICANCE: These proposed methods have the potential for enabling knee joint acoustics measurement outside the clinic/lab and permitting long-term monitoring of knee health for patients rehabilitating an acute knee joint injury.

A novel method to assess angle sensor performance for wearable exoskeletal joint kinematics.

Full range of motion (ROM) at a joint is necessary for efficient and adaptive movement; as such, it is an essential clinical evaluation measure for assessing an individual's motor function, which can be affected by any number of musculoskeletal injuries and neuropathies. Measurement of joint ROM in the clinic has classically been accomplished statically through the use of a manual goniometer. More recent efforts in the fields of prosthetics and orthotics have demonstrated the potential utility of wearable systems (e.g., exoskeletons, orthoses) designed to control joint motion(s) and instrumented with sensors capable of capturing joint angle data dynamically. This paper presents a novel methodology to assess the performance of a variety of angle sensors in the context of wearable joint angle measurement, particularly for use in articulated ankle-foot orthoses (AFOs). Dynamic and static errors are considered, and a cost-benefit analysis of a variety of off-the-shelf and custom-built sensors is reported to provide comparative data for selecting a sensor to measure joint motion in wearable exoskeletal systems. All of the sensors considered reported angular errors below 5° across all tests, though the optical encoder consistently demonstrated the highest accuracy (<;0.7°) and precision, and both the resistive potentiometers exhibited the highest error in the dynamic tests (1.5° to 4°). The anisotropic magnetoresistive (AMR) sensor demonstrated the highest performance-to-cost ratio.

Optimal placement and angulation of a dorsal motion control mechanism to resist heel rise in an orthosis.

BACKGROUND: No studies have determined the optimal location and angular orientation for orthotic dorsal control mechanisms (e.g. dorsal foot strap) for use in lower limb orthoses to resist foot motion for maximum user function and comfort. OBJECTIVES: To determine the optimal dorsal location and angular orientation of an orthotic control mechanism to resist foot movements associated with heel rise. STUDY DESIGN: An in vitro cadaveric study quantified the dorsal force required to resist foot motion. METHODS: The study simulated heel rise and quantified the force of a dorsal control mechanism in nine test conditions comprising three angles (75°, 90°, and 105°) and three longitudinal axis positions at 2.0 cm increments. RESULTS: The test condition representing the longest lever arm (proximal location) applied at an obtuse angle (105°) required the least force (55.6 N) to constrain foot motion, whereas the shortest lever arm (distal location) at the acute angle (75°) required the greatest force (90.4 N) to constrain foot motion. CONCLUSION: To resist foot motion relative to the orthosis, clinicians should aim for the most proximal placement (longest lever arm) at an obtuse angle (105°) with the intention that the resultant controlling force be perpendicular to the bony structure. CLINICAL RELEVANCE: A dorsal foot control strap applies a critical orthotic corrective force, as part of a force couple to restrict motion of the foot and shank in lower limb orthoses. Foundational orthotic principles that stipulate optimal clinical placement and angular orientation are necessary to ensure maximum function and comfort to users.

Symmetrical kinematics does not imply symmetrical kinetics in people with transtibial amputation using cycling model.

People with amputation move asymmetrically with regard to kinematics (joint angles) and kinetics (joint forces and moments). Clinicians have traditionally sought to minimize kinematic asymmetries, assuming kinetic asymmetries would also be minimized. A cycling model evaluated locomotor asymmetries. Eight individuals with unilateral transtibial amputation pedaled with 172 mm-length crank arms on both sides (control condition) and with the crank arm length shortened to 162 mm on the amputated side (CRANK condition). Pedaling kinetics and limb kinematics were recorded. Joint kinetics, joint angles (mean and range of motion [ROM]), and pedaling asymmetries were calculated from force pedals and with a motion capture system. A one-way analysis of variance with tukey post hoc compared kinetics and kinematics across limbs. Statistical significance was set to p

A portable powered ankle-foot orthosis for rehabilitation.

Innovative technological advancements in the field of orthotics, such as portable powered orthotic systems, could create new treatment modalities to improve the functional out come of rehabilitation. In this article, we present a novel portable powered ankle-foot orthosis (PPAFO) to provide untethered assistance during gait. The PPAFO provides both plantar flexor and dorsiflexor torque assistance by way of a bidirectional pneumatic rotary actuator. The system uses a portable pneumatic power source (compressed carbon dioxide bottle) and embedded electronics to control the actuation of the foot. We collected pilot experimental data from one impaired and three nondisabled subjects to demonstrate design functionality. The impaired subject had bilateral impairment of the lower legs due to cauda equina syndrome. We found that data from nondisabled walkers demonstrated the PPAFO's capability to provide correctly timed plantar flexor and dorsiflexor assistance during gait. Reduced activation of the tibialis anterior during stance and swing was also seen during assisted nondisabled walking trials. An increase in the vertical ground reaction force during the second half of stance was present during assisted trials for the impaired subject. Data from nondisabled walkers demonstrated functionality, and data from an impaired walker demonstrated the ability to provide functional plantar flexor assistance.

Experimental evaluation of a portable powered ankle-foot orthosis.

Ankle-foot orthoses (AFOs) ameliorate the impact of impairments to the lower limb neuromuscular motor system that affect gait. Emerging technologies provide a vision for fully powered, untethered AFOs. The portable powered AFO (PPAFO) provides both plantarflexor and dorsiflexor torque assistance via a bi-directional pneumatic rotary actuator. The system uses a portable pneumatic power source (bottle of compressed CO(2)) and embedded electronics to control foot motion during level walking. Experimental data were collected to demonstrate functionality from two subjects with bilateral impairments to the lower legs. These data demonstrated the PPAFO's ability to provide functional assistance during gait. The stringent design requirements of light weight, small size, high efficiency and low noise make the creation of daily wear assist devices challenging; but once such devices appear, they will present new opportunities for clinical treatment of gait abnormalities.

Torsional stiffness of an intramedullary nail versus blade plate fixation for tibiotalocalcaneal arthrodesis: a biomechanical study.

The purpose of this investigation is to compare the rotational stability of intramedullary rod fixation with blade plate and screw fixation in tibiotalocalcaneal arthrodesis. Five matched pairs of cadaver ankles were randomly fixated with a lateral blade plate and screws or a retrograde intramedullary nail. The bone mineral density (BMD) for each sample was ascertained. These samples were tested through internal and external rotation of 0.5 degrees/s until 7 N-m was achieved. The torsional stiffness of each specimen was determined from the linear slope of the torque-rotation curve. No statistical difference in internal (p=.11) or external (p=.36) rotation for the matched pairs was noted. Data were excluded from one intramedullary sample secondary to early failure of the tibia. A trend toward increased rotational stability in the intramedullary group versus plate fixation in specimens with lower BMD was observed. These findings suggest no rotational biomechanical advantage of intramedullary nail compared to blade plate fixation in a cadaveric tibiotalocalcaneal arthrodesis model.

The influence of metatarsal support height and longitudinal axis position on plantar foot loading.

BACKGROUND: Metatarsal supports are effective at decreasing plantar foot pressures at the metatarsal heads, however, little is known about the dependence of this decrease upon height and position. METHODS: Barefoot static stance pressure measurements were recorded during standing in single limb support (n=22). Two metatarsal support heights (5mm, 10mm) were evaluated in six positions at 5mm increments (0, 5, 10, 15, 20, 25 mm) proximal to the metatarsal heads along the longitudinal axis of the foot. The barefoot condition with no metatarsal support served as the control. Mean force was measured for each test condition. The findings of this study are limited to the barefoot (unshod) condition. FINDINGS: Mean plantar force decreased significantly under the second metatarsal head with both 5 and 10mm metatarsal supports compared to the control, and 10mm metatarsal support compared with 5mm metatarsal support (P<0.05) while no statistically significant differences were noted relative to longitudinal axis position. INTERPRETATION: The results of this study suggest that the thickness of a metatarsal support is a determinant factor in regulating plantar loading. Surprisingly, the longitudinal axis location of a metatarsal support does not appear to be as important as clinically presumed since the data showed that the force decrease was similar for all positions from 5 to 25 mm. Thus, the orthotic induced effect of a metatarsal support seems to have a sizable interaction range that has not previously been reported. We speculate that the metatarsal support's fulcrum and lift effect can be sustained at a more proximal position due to the foot's rigidity as a lever and the manner in which a metatarsal support interacts with the plantar aponeurosis.