Image cytometric evaluation of nuclear texture features and DNA content of the reticular form of oral lichen planus.

OBJECTIVE: To analyze image cytometric chromatin changes reflected in nuclear texture features and DNA ploidy of oral lichen planus in relation to the normal buccal mucosa and buccal mucosa expressing malignancy-associated changes in cancer patients. STUDY DESIGN: Twenty-eight patients with the reticular form of oral lichen planus, with a follow-up period of 25 years, 50 healthy controls and 50 lung cancer patients were included in the study. Scrapings of buccal mucosa were suspended in transport medium. Monolayer filter preparations were Feulgen-thionin stained. Image cytometric analysis was performed by Cyto-Savant. RESULTS: All oral lichen planus specimens in our study were diploid. In univariate analysis, differences between the normal buccal mucosa and oral lichen planus were found in several nuclear texture features, which gave an 80% correct classification rate in multivariate analysis. In the second part of the study, the classifier that recognizes malignancy-associated changes on the buccal mucosa of patients with lung cancer correctly recognized > 80% of oral lichen planus samples as normal buccal mucosa. CONCLUSION: Our results indicate that chromatin changes in oral lichen planus exist compared to normal cells; however, the chromatin structure of the reticular form of oral lichen planus does not express malignancy-associated changes and is more similar to normal squamous cells.

Sinus maxillaris mycetoma of odontogenic origin: case report

O número de infecções fúngicas tem aumentado. Infecções fúngicas com a espécie Aspergillus, presentes nas cavidades dos maxilares, podem estar relacionadas com os ápices dos dentes do arco superior. Mudanças diagnósticas nos seios maxilares e certos tipos de dores faciais podem ser indicativos de infecção fúngica. Os autores relatam um caso de sinusite por aspergilose (aspergillosis sinusitis) e descrevem os métodos de diagnóstico e tratamento desta infecção, que pode estar relacionada com o tratamento endodôntico.

Malignant potential of the reticular form of oral lichen planus over a 25-year observation period in 55 patients from Slovenia.

A retrospective evaluation of the reticular form of oral lichen planus was made on the basis of clinical and histopathological observations in 55 patients. Patients were re-examined once every six months over a 25-year period. Biopsies were taken from all lesions. No cases of complete remission and no cases of malignant transformation were recorded. Our findings suggest that the reticular form of oral lichen planus is not a precancerous lesion.