RESUMO
Clinico-epidemiological analysis and etiological verification of the outbreak of respiratory infection among school children in a rural district of the Khabarovsk territory, registered in spring 1997, were made. According to clinical signs, one-third of the patients had whooping cough, while the rest of the children exhibited the signs of respiratory infection with the symptoms of longering bronchitis. A half of the children had not been vaccinated against whooping cough, as they had been given injections of adsorbed DT vaccine with reduced antigen content. Etiologically, the diagnosis of whooping cough was confirmed in 57% of the patients with 47.4% of them having Bordetella pertussis monoinfection and 52.6% having mixed infection, mainly in combination with chlamydiosis. Whooping cough took an abnormal course under these circumstances. Treatment with erythromycin produced a good effect.
Assuntos
Surtos de Doenças , Infecções Respiratórias , Adolescente , Criança , Infecções por Chlamydia/diagnóstico , Infecções por Chlamydia/epidemiologia , Infecções Comunitárias Adquiridas/diagnóstico , Infecções Comunitárias Adquiridas/epidemiologia , Infecções Comunitárias Adquiridas/etiologia , Diagnóstico Diferencial , Humanos , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/etiologia , População Rural , Sibéria/epidemiologia , Vacinação , Coqueluche/diagnóstico , Coqueluche/epidemiologiaRESUMO
Prognostic value of markers of cytomegalovirus infection (CMV) in pregnant women for the neonatal status was assessed. Detection of such markers as antiCMV IgM and CMV DNA in cervical secretion by DNA dot-spot hybridization in women with a complicated course of pregnancy indicates a 5.7% risk of delivery of children with stable symptoms. Studies of antibodies to pre-early proteins (IE CMV) showed that antiCMV IgG to IE are more incident in pregnant women than antiCMV IgM; moreover, antiCMV IgG to IE but not antiCMV IgM are detected in umbilical blood. The results of detection of antiCMV IgG and IgM to IE correlated with the clinical characteristics of newborns.
Assuntos
Infecções por Citomegalovirus/diagnóstico , Doenças Fetais/diagnóstico , Diagnóstico Pré-Natal , Biomarcadores , Feminino , Humanos , Recém-Nascido , GravidezAssuntos
Infecções Respiratórias/etiologia , Doença Aguda , Adolescente , Criança , Infecções por Chlamydia/diagnóstico , Infecções por Chlamydia/epidemiologia , Infecções por Chlamydia/etiologia , Diagnóstico Diferencial , Humanos , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/epidemiologia , Sibéria/epidemiologia , Coqueluche/diagnóstico , Coqueluche/epidemiologia , Coqueluche/etiologiaRESUMO
Numerous examinations during 12-36 months of 16 children suffering from myocarditis and their 37 relatives revealed long-term persistence of Coxsackie A13/A18 viruses in the familial foci of infection in 13 cases. In addition, 9 families were found to have foci of Coxsackie B virus infection of which 2 were also persistent (Coxsackie B1 and B3) and 7 transitory. In 8 families, Coxsackie B viruses circulated simultaneously with Coxsackie A13/A18.
Assuntos
Infecções por Coxsackievirus/genética , Reservatórios de Doenças , Enterovirus/isolamento & purificação , Microbiologia Ambiental , Miocardite/genética , Adulto , Anticorpos Antivirais/análise , Criança , Infecções por Coxsackievirus/imunologia , Infecções por Coxsackievirus/microbiologia , Enterovirus/imunologia , Feminino , Humanos , Masculino , Miocardite/imunologia , Miocardite/microbiologia , Linhagem , Fatores de TempoRESUMO
Virological and clinico-instrumental examinations were carried out three times during one year in 13 patients with rheumatic carditis and 34 of their relatives from 13 families. Besides, probands from 5 families had been examined 1-3 years before this study during treatment for rheumocarditis. Among 62 virus strains isolated from feces, blood, and nasopharyngeal washings in the family foci 40 were Coxsackie A13, 12: Coxsackie B1, B2, B5; 10 viruses were not identified. Coxsackie A13 virus was isolated from probands, siblings and parents in 11 out of 13 families. Virus-neutralizing antibodies to it were demonstrated in the great majority of probands and relatives, including those families where no virus had been isolated. Coxsackie A13 virus and antibodies to it were shown to persist throughout the observation period in most families.
Assuntos
Infecções por Coxsackievirus/microbiologia , Enterovirus/isolamento & purificação , Cardiopatia Reumática/microbiologia , Adolescente , Adulto , Anticorpos Antivirais/análise , Criança , Pré-Escolar , Infecções por Coxsackievirus/genética , Efeito Citopatogênico Viral , Enterovirus/imunologia , Fezes/microbiologia , Feminino , Humanos , Masculino , Nasofaringe/microbiologia , Cardiopatia Reumática/genéticaRESUMO
The pathological process due to Coxsackie A18 virus and hemolytic streptococcus infection was studied in adult white mice. Their synergistic effect was established as manifested by longer periods of virus detection in the blood and heart and the detection of the streptococcus in animals infected with an 8-fold lower dose. In cases of combined infection, signs of dystrophy, destruction and proliferation developed in the myocardium reaching the highest intensity when the virus and the microbe had been inoculated simultaneously.