RESUMO
The paper covers the results of 32 endoscopic studies. The D. E. Korzhevsky procedure was used to determine the activity of NADP.H diaphorase, a NO-synthase marker, in gastric mucosal biopsy specimens from patients with acute and scarring peptic ulcer. A high activity of NO synthase was found in patients with acute ulcer and its inhibition was ascertained in those with scarring ulcer. The findings lead to the conclusion that NO-dependent mechanisms are involved in the pathogenesis of an ulcerative process.
Assuntos
Úlcera Duodenal/enzimologia , Mucosa Gástrica/enzimologia , Óxido Nítrico Sintase/metabolismo , Adolescente , Adulto , Biomarcadores , Biópsia , Progressão da Doença , Úlcera Duodenal/patologia , Feminino , Mucosa Gástrica/patologia , Humanos , Masculino , NADPH Desidrogenase/metabolismoRESUMO
Basing upon the histochemical study of SDG and NO-synthase activity in 68 biopsies taken from patients with duodenal ulcer the connection between the clinical specificity and the activity of the disease the SDG activity decreases, while that of NO-synthase increases. At the phase of cicatrization the opposite process is going on. The authors connect the phenomena under investigation with the vasodilatory and protective abilities of the nitrogen oxide.
Assuntos
Úlcera Duodenal/etiologia , Duodeno/patologia , Mucosa Intestinal/patologia , Biópsia , Úlcera Duodenal/enzimologia , Úlcera Duodenal/patologia , Duodeno/enzimologia , Histocitoquímica , Humanos , Mucosa Intestinal/enzimologia , Óxido Nítrico Sintase/metabolismo , Oxirredução , Succinato Desidrogenase/metabolismoAssuntos
Úlcera Duodenal/fisiopatologia , Cicatrização , Adulto , Úlcera Duodenal/tratamento farmacológico , Endoscopia Gastrointestinal , Infecções por Helicobacter/tratamento farmacológico , Infecções por Helicobacter/fisiopatologia , Helicobacter pylori , Humanos , Masculino , Gravação em Vídeo , Cicatrização/efeitos dos fármacosRESUMO
The authors present an analysis of the general morbidity among sailors. It was established that the leading place is occupied by diseases of the respiratory organs. It is proposed to include in the system of medical choice of sailors examination of the external respiration and immune status.