[Theory of systems generation at its present stage]. / Teoriia sistemogeneza na sovremennom étape.

Anokhin's theory of systems genesis describes the selective development and maturation of morphofunctional associations of cells in response to ecological factors. This theory is corroborated by data obtained as a result of studying the embryonal and early postnatal development of man and animals. Further progress of this theory is based on a more detailed studying of the cellular mechanisms and the selectivity of establishment of intercellular contacts. In the postnatal period the formation of the complicate functional system of behaviour is studied. The discrete, "quantum" character of the behaviour formation is investigated in detail. A particular attention is paid to the psychic functional systems on which man's abstract thinking is based. Studying of the maturation sequence of functional systems (intersystem heterochronism) allows one to substantiate a concept on system-character periodization of development. The importance of interrelations within a population for formation of the body's functional systems can be seen on the examples of the interrelations "mother--foetus", and "mother--child", as well as the interrelations between individuals in a group. It is possible, that the systems genesis theory will be used in the nearest future in pediatric practice more extensively.

[Role of the determinance factor in formation of systemic connections during ontogenesis]. / O roli faktora determinirovannosti v obrazovanii sistemnykh sviazei v ontogeneze

Behaviour of differentiating neuroblasts was studied in the nervous tissue culture of the newborn rats cortex and medulla oblongata of the rabbit embryo. The phasic-contrast microscopy and study of fixated preparations revealed that distribution of the neuroblasts over the substrate, their mutual orientation, the character of their branches growth and formation of contacts occur in vitro involving certain stages of morphological forming of the brain systemic organization. The clear trend of the neuroblasts behaviour to formation of certain connections suggests their genetic determinance. The distribution of neuroblasts over the substrate from different brain areas has its own phenotypic features.

[Realization of systemic relations in the behavior of early neuroblasts in nerve tissue cultures]. / O realizatsii sistemnykh sviazei v povedenii rannikh neiroblastov v usloviiakh kul'tury nervoi tkani.

When cultivating the nervous tissue of newborn rats, rabbit embryos and tadpoles (as whole fragments or dissociated cells), 3 groups of neuroblasts are distinguished: differentiating, migrating and with growing processes. These groups correspond to different stages of neuroblast development in vivo and their presence in the tissue cultures of different brain regions reflects the heterochrony of cell development in these regions. The neuroblasts realize their morphogenetic potential within several days of cultivation irrespective of the contact with the other cells but the subsequent differentiation (dendrite branching, nuclear clearance etc.) proceeds only in cells united in aggregates.