RESUMO
In experiments on the white rats it was established that the citalopram in dose 5 mg/kg significantly affects the circadian rhytms of excretory function of kidneys, especially at night. We conclude that serotonin, which content is increased by citalopram, may serve as a neurotransmitter in circadian rhytms regulation.
Assuntos
Ritmo Circadiano/efeitos dos fármacos , Citalopram/farmacologia , Diurese/efeitos dos fármacos , Taxa de Filtração Glomerular/efeitos dos fármacos , Rim/efeitos dos fármacos , Inibidores Seletivos de Recaptação de Serotonina/farmacologia , Animais , Creatinina/metabolismo , Rim/fisiopatologia , Ratos , Ratos WistarRESUMO
In experiments on the white rats it was established that the steady-state (during 8 days) darkness results in desynchronization of the circadian rhythms of kidney excretory function. Hydrocortisone hydrochloride 5 mg/kg during constant darken resulted in poluria, natriuresis and acidogenesis without influencing the acid phosphates excretion.
Assuntos
Ritmo Circadiano/efeitos dos fármacos , Escuridão , Diurese/efeitos dos fármacos , Hidrocortisona/farmacologia , Rim , Amônia/urina , Animais , Creatinina/urina , Rim/efeitos dos fármacos , Rim/metabolismo , Rim/fisiologia , Natriurese/efeitos dos fármacos , Fosfatos/urina , Ratos , Ratos WistarRESUMO
In experiments on White rats was established, that the steady-state darkness during 8 days results in desynchronizes of the circadian rhythms of sodium ions, titrate acids and ammonium excretion with moving from 23.00-2.00 hours to 2.00-14.00 hours.
Assuntos
Ritmo Circadiano/fisiologia , Escuridão , Diurese , Rim/fisiologia , Animais , Creatinina/urina , Testes de Função Renal , Potássio/urina , Compostos de Amônio Quaternário/urina , Ratos , Ratos Wistar , Sódio/urinaRESUMO
Epiphysectomy in adult pubescent Wistar rats causes polyuria and Na uresis at the expense of the increased rate of the glomerular filtration and sodium filtration charge. Melatonin in a dose of 4.31 mkM/100 g of the body weight increased the glomerular filtration of both sodium and water and stimulated the sodium tubular transport in rats with intact epiphysis and did not normalize changes of the nephron excretory activity after epiphysectomy.