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1.
IEEE Trans Biomed Eng ; 71(2): 446-455, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37603484

RESUMO

OBJECTIVE: Total artificial hearts (TAH) serve as a temporary treatment for severe biventricular heart failure. The limited durability and complication rates of current devices hamper long-term cardiac replacement. The aim of this study was to assess the feasibility of a novel valveless pumping principle for a durable pulsatile TAH (ShuttlePump). METHODS: The pump features a rotating and linearly shuttling piston within a cylindrical housing with two in- and outlets. With a single moving piston, the ShuttlePump delivers pulsatile flow to both systemic and pulmonary circulation. The pump and actuation system were designed iteratively based on analytical and in silico methods, utilizing finite element methods (FEM) and computational fluid dynamics (CFD). Pump characteristics were evaluated experimentally in a mock circulation loop mimicking the cardiovascular system, while hemocompatibility-related parameters were calculated numerically. RESULTS: Pump characteristics cover the entire required operating range for a TAH, providing 2.5-9 L/min of flow rate against 50-160 mmHg arterial pressures at stroke frequencies of 1.5-5 Hz while balancing left and right atrial pressures. FEM analysis showed mean overall copper losses of 8.84 W, resulting in a local maximum blood temperature rise of <2 K. The CFD results of the normalized index of hemolysis were 3.57 mg/100 L, and 95% of the pump's blood volume was exchanged after 1.42 s. CONCLUSION AND SIGNIFICANCE: This study indicates the feasibility of a novel pumping system for a TAH with numerical and experimental results substantiating further development of the ShuttlePump.


Assuntos
Insuficiência Cardíaca , Coração Artificial , Coração Auxiliar , Humanos , Pressão Arterial , Fluxo Pulsátil
2.
Artigo em Inglês | MEDLINE | ID: mdl-35130156

RESUMO

Stabilization of the position and orientation of non-spherical, sub-wavelength particles in mid-air is required for using acoustic levitation forces in applications such as automation of micro manufacturing processes, 3-D scanning, and inspection. Acoustic locking has previously been demonstrated by time-multiplexing of different acoustic traps at the same frequency. In this case, the magnitude of the acoustic levitation forces and the stabilizing torque are coupled by the ratio of the durations during which the different traps are applied and cannot be adjusted independently assuming operation at maximum power. This work presents a compact device that uses a method for independently adjusting the vertical trapping forces and the stabilizing torque using two different ultrasonic frequencies. A 40-kHz vertical standing wave is used to generate levitation forces that counteract the gravitational force. Additionally, a 25-kHz horizontal standing wave is used to generate a tunable stabilizing torque. Using this method, objects made from high-density materials across a wide range of geometries can be locked acoustically with increased stability compared with state-of-the-art methods. This is demonstrated by locking tin cuboids with a density of 7.3 g/cm3 and plastic cuboids with average side lengths between 0.9 and 3.5 mm. The experimental results demonstrate torsional spring constants of up to 50 nN · m/rad and an orientation stability of <7.5°.


Assuntos
Acústica , Som , Fenômenos Mecânicos , Ultrassom
3.
Artigo em Inglês | MEDLINE | ID: mdl-35120003

RESUMO

The achievable rotational frequency of acoustically levitated particles is limited by the suspension stability and the achievable driving torque. In this work, a spherical ring arrangement of piezoelectric transducers and an improved excitation concept are presented to increase the rotational speed of an acoustically levitated particle by more than a factor of 10 compared to previously published results. A maximum rotational frequency of 3.6 kHz using asymmetric expanded polystyrene (EPS) particles is demonstrated. At such rotational speeds, high-frequency resonances of the transducers cause disturbances of the acoustic field which present a previously unexplored limit to the achievable manipulation rate of the particle. This limit is investigated in this work by means of calculations based on an analytical model and high precision measurements of the transducer characteristics beyond the conventional frequency range.


Assuntos
Acústica , Transdutores , Rotação
4.
Semin Thorac Cardiovasc Surg ; 34(1): 238-248, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34166811

RESUMO

Treatment of univentricular hearts remains restricted to palliative surgical corrections (Fontan pathway). The established Fontan circulation lacks a subpulmonary pressure source and is commonly accompanied by progressively declining hemodynamics. A novel cavopulmonary assist device (CPAD) may hold the potential for improved therapeutic management of Fontan patients by chronic restoration of biventricular equivalency. This study aimed at translating clinical objectives toward a functional CPAD with preclinical proof regarding hydraulic performance, hemocompatibility and electric power consumption. A prototype composed of hemocompatible titanium components, ceramic bearings, electric motors, and corresponding drive unit was manufactured for preclinical benchtop analysis: hydraulic performance in general and hemocompatibility characteristics in particular were analyzed in-silico (computational fluid dynamics) and validated in-vitro. The CPAD's power consumption was recorded across the entire operational range. The CPAD delivered pressure step-ups across a comprehensive operational range (0-10 L/min, 0-50 mm Hg) with electric power consumption below 1.5 W within the main operating range. In-vitro hemolysis experiments (N = 3) indicated a normalized index of hemolysis of 3.8 ± 1.6 mg/100 L during design point operation (2500 rpm, 4 L/min). Preclinical investigations revealed the CPAD's potential for low traumatic and thrombogenic support of a heterogeneous Fontan population (pediatric and adult) with potentially accompanying secondary disorders (e.g., elevated pulmonary vascular resistance or systemic ventricular insufficiency) at distinct physical activities. The low power consumption implied adequate settings for a small, fully implantable system with transcutaneous energy transfer. The successful preclinical proof provides the rationale for acute and chronic in-vivo trials aiming at the confirmation of laboratory findings and verification of hemodynamic benefit.


Assuntos
Técnica de Fontan , Coração Auxiliar , Adulto , Criança , Técnica de Fontan/efeitos adversos , Coração Auxiliar/efeitos adversos , Hemodinâmica , Hemólise , Humanos , Modelos Cardiovasculares , Resultado do Tratamento
5.
IEEE Trans Biomed Eng ; 68(4): 1370-1378, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33048670

RESUMO

OBJECTIVE: This paper presents a comparative study of computational fluid dynamics (CFD) simulations and in vitro hemolysis examinations of a bearingless centrifugal blood pump. The outcomes of the in vitro study are analyzed with the help of CFD hemolysis models. METHODS: Several pump prototypes were manufactured and tested. Each model was implemented in a CFD framework and simulated with different Eulerian hemolysis models. The outcomes are compared to experimental data. The model achieving the highest correlation is used to explain the in vitro outcomes in detail. RESULTS: It is shown that a double-stage model achieves the best correlation. The sensitivity of the simulation is considerably lower than that of in vitro tests. The CFD model reveals that most of the cell destruction is caused in the radial gap of the pump. Further critical regions are the bottom volume and the shroud clearance gap. Only 0.5% of the priming volume is subject to overcritical shear stress. CONCLUSION: Cell compatibility can be improved by increasing the radial gap, lowering the shroud and hub clearance gaps, and increasing the fillet radius of the inlet nozzle. CFD models can be used to examine the cell damage effects and help to further improve the pump design. SIGNIFICANCE: This paper compares different Eulerian CFD hemolysis models, parameter sets, and equivalent shear stresses to several in vitro hemolysis tests. The sensitivity of the models is compared to that of in vitro studies. It is shown that CFD simulations have their limitations but can help with interpreting the outcomes of in vitro studies.


Assuntos
Coração Auxiliar , Hidrodinâmica , Simulação por Computador , Hemólise , Humanos , Estresse Mecânico
6.
IEEE Open J Eng Med Biol ; 1: 316-323, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-35402951

RESUMO

Goal: The importance of the main impeller design parameters in bearingless centrifugal pumps with respect to hemolysis for cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) applications are studied in this work. Methods: Impeller prototypes were designed based on theoretical principles. They were manufactured and their hydraulic and hemolytic performance were analyzed experimentally. The cell compatibility is benchmarked against commercially available centrifugal blood pumps BPX-80 (Medtronic) and FloPump 32 (International Biophysics Corporation). Results: The developed prototypes outperform the BPX-80 and FloPump 32 with regard to hemocompatibility by more than a factor of 4.5. The implemented pump features reduced overall and priming volumes. A significant improvement of the cell compatibility is achieved by increasing the radial gap between the impeller and the pump head. The blade should be sufficiently high and a blade outlet angle of 90° provides favorable performance. No correlation between the hydraulic and hemolytic performance is observed. Conclusions: This work identified the most important geometrical parameters of the impeller for blood pumps with respect to cell compatibility. This provides valuable design guidelines for improving existing pumps.

7.
Sci Adv ; 4(1): e1701519, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29326976

RESUMO

Our world is increasingly powered by electricity, which is largely converted to or from mechanical energy using electric motors. Several applications have driven the miniaturization of these machines, resulting in high rotational speeds. Although speeds of several hundred thousand revolutions per minute have been used industrially, we report the realization of an electrical motor reaching 40 million rpm to explore the underlying physical boundaries. Millimeter-scale steel spheres, which are levitated and accelerated by magnetic fields inside a vacuum, are used as a rotor. Circumferential speeds exceeding 1000 m/s and centrifugal accelerations of more than 4 × 108 times gravity were reached. The results open up new research possibilities, such as the testing of materials under extreme centrifugal load, and provide insights into the development of future electric drive systems.

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