[Preclinical evaluation of the effect of Metrop GP on acute toxicity and hepatotoxicity of chemotherapy].

Our paper presents the results of preclinical evaluation of the mitigating effect of Metrop GP on the acute toxicity and hepatotoxicity induced by paclitaxel and doxorubicin treatment using functional samples and biochemical and morphological techniques.

[Results of preclinical study of inactivated subunit adsorbed monovalent influenza vaccine "PANDEFLU"].

AIM: To perform preclinical study of subunit monovalent adsorbed inactivated influenza vaccine "PANDEFLU" [strains A/California/7/2009 (HIN1)v]. MATERIALS AND METHODS: Preclinical study of acute toxicity on experimental animals (assessment of vaccine's toxic effects on organs and body systems; pathomorphologic study of organs and tissues after administration of the vaccine; assessment of its influence on hematologic indicators). RESULTS: It was shown that administration of the vaccine did not lead to death of animals as well as to decrease of body mass or development of pathologic, focal sclerotic changes in parenchymal cells and visceral stroma; the vaccine did not negatively change hematologic and biochemical indicators of blood. Results of necropsy and histological study after acute administration of the vaccine in standard dose did not lead to irritation, inflammation or destruction of tissues in the place of inoculation. The vaccine was apyrogenic and did not have local irritating and allergenic effects. Status of animals after acute inoculation of the vaccine demonstrated its good tolerability and safety in doses exceeding standard human doses more than tenfold. CONCLUSION. Performed research demonstrated absence of contraindications for conduction of clinical trials of "PANDEFLU" vaccine on limited contingent of volunteers.

[Results of preclinical studies of live monovalent influenza vaccine Influvir].

AIM: To perform preclinical assessment of new live monovalent vaccine Influvir against pandemic influenza virus A/H1N1 [strainA/17/California/2009/38 (H1N1)]. MATERIALS AND METHODS: Preclinical studies of acute toxicity and effect of Influvir vaccine on systems and organs of laboratory animals (rats and outbred white mice) was performed according to modern requirements of Institute of Toxicology. RESULTS: According to results of toxicometry and necroscopy, live monovalent influenza vaccine Influvir during intransal application was safe and had good tolerability during 14 days of observation for experimental animals after acute application. Performed preclinical studies allow to label the studied vaccine as class V virtually nontoxic drugs. CONCLUSION: According to results of preclinical studies, clinical trials of live monovalent intranasal influenza vaccine Influvir can be permitted.

[Role of abnormalities of the lung surfactant system in the development of respiratory failure in critical states caused by acute neurotoxic poisoning]. / Rol' patologii surfaktantnoi sistemy legkikh v razvitii dykhatel'noi nedostatochnosti pri kriticheskikh sostoianiiakh, obuslovlennykh ostrymi otravleniiami iadami neirotoksicheskogo deistviia.

Clinical data on the surfactant system of the lungs during poisoning with neurotoxic toxins are presented and approaches to drug correction of lung system disorders in severe intoxication with neurotoxic agents are offered.

Experimental study of biological activity of angiogen in experimental cardiovascular and hemostasis pathology.

Positive effects of angiogen, a preparation containing succinic and acetylsalicylic acids, on ECG, blood clotting, and lipid metabolism were demonstrated on animals with experimental cardiovascular disease induced by repeated injections of norepinephrine.

[Effect of the transcranial electrical stimulation of the endorphinergic brain structures on the functional activity of hepatocytes after toxic exposure]. / Vliianie transkranial'noi élektrostimuliatsii éndorfinnykh struktur mozga krys na funktsional'nuiu aktivnost' gepatotsitov pri ikh toksicheskom povrezhdenii.

Biochemical events of the rat hepatocytes cytolysis and deterioration of their synthetic activity and detoxification ability, as well as morphological events of lipid degeneration after acute poisoning with dichloretane and CCl4, were significantly reduced by effects of transcranial stimulation (TES). Blockade of the TES effects with naloxone revealed its endorphinergic nature. Combined effects of the TES and Essenciale preparation were lower than separate those of these agents. The TES effects were clinically corroborated in treatment of toxic hepatitis.

[Effectiveness of alupent in disorders of the pulmonary surfactant system caused by chlorophos poisoning]. / Effektivnost' alupenta pri narusheniiakh surfaktantnoi sistemy legkikh, vyzvannykh otravleniem khlorofosom.

Acute oral chlorophos poisoning of laboratory animals was shown to result in a decrease of the pulmonary surfactant system according to the severity of intoxication. Alupent in combination with atropine and dipyroxime prevented the disturbances of the system.