[Effect of preliminary antibiotic administration on the course of ether anesthesia]. / Vliianie predvaritel'nogo vvedeniia antibiotikov na techenie éfirnogo narkoza.

The effect of pretreatment with benzylpenicillin, tetracycline hydrochloride and streptomycin sulfate on the course of either anesthesia was studied in experiments on animals. Benzylpenicillin and tetracyclin hydrochloride neither significantly changed the reactivity of the mouse body nor affected the course of ether anesthesia. Administration of streptomycin sulfate to mice and dogs was attended by the reduced function of the central nervous system. The course of ether anesthesia changed accordingly. The reaction of the animals who had been pretreated with streptomycin sulfate was determined by the species features. In white mice, the antibiotic increased the resistance to the toxic effect of ether while in the dogs, it decreased, on the contrary, the body resistance under anesthesia, thereby accelerating the animals' death.

[Effect of streptomycin sulfate on the process of higher nervous activity recovery in dogs in the postanesthesia period]. / Vliianie streptomitsina sul'fata na protsess vosstanovleniia vysshei nervnoi deiatel'nosti sobak v postnarkoticheskom periode.

The effect of streptomycin on recovery of the higher nervous activity during the postanesthesia period was studied on 3 dogs with the method of the conditioned reflexes. It was found that streptomycin sulphate administered in a dose of 25 mg per 1 kg body weight induced no changes in the conditioned reflexes of the non-anesthetized animals. After ether anesthesia disorders in the conditioned and unconditioned reflexes, as well as differentiation was observed during the postanesthesia period. On an average they normalized in 7, 6 and 2 days respectively from the moment of anesthesia. When streptomycin sulphate was used during the post anesthesia period, both the strength and the character of the disorders in the conditioned reflexes changed. In this case recovery of the conditioned and unconditioned reflexes was registered in 2 days, while that of the differential inhibition was registered in 3--7 days from the moment of anesthesia.

[The effect of mixtures of caffeine, glucose and ascorbic acid on conditioned reflex activity in dogs during the postanesthetic period]. / Vliianie smesi kofeina, gluikozy i askorbinovoi kisloty na uslovnoreflektornuiu deiatel'nost' v postnarkoticheskom periode u sobak

It was shown in experiments on four dogs by the conditioned method that the period of recovery of conditioned activity after one hour ether anaesthesia tested 7 to 7.5 days. Premedication with a mixture of caffeine, glucose and ascorbic acid reduced the recovery time to four or five days. After the administration of the complex in the postanaesthetic period (in 2.5 hours after anaesthesia) the stabilizing effect was still more pronounced. Thus, the recovery time of unconditioned and conditioned reflexes and differentiation was reduced to three or four days.