RESUMO
151 rheumatics aged between 16 and 70 were examined. 110 of them had active rheumatism, in 41 inactive form of the disease was diagnosed. Various gastric changes found in 90.5% of patients were related both to rheumatism and adverse effects of antirheumatic treatment as well as to concomitant diseases of stomach and duodenum. Achlorhydria resistant to pentagastrin was rather in patients with rheumatism. This may be explained by predominant lesions of main cells while parietal cells remain quite intact.
Assuntos
Doenças Reumáticas/fisiopatologia , Estômago/fisiopatologia , Adolescente , Adulto , Idoso , Mucosa Gástrica/metabolismo , Mucosa Gástrica/patologia , Humanos , Pessoa de Meia-Idade , Doenças Reumáticas/complicações , Gastropatias/etiologia , Gastropatias/fisiopatologiaRESUMO
Five rheoparodontographic curve types were distinguished, characterizing the severity of periodontal condition and the underlying disease. Morphologic examinations have revealed specific features of involvement of the periodontal regional hemomicrocirculation bed, leading to disorders in energy metabolism and development of circulatory and tissue hypoxia. The detected changes result in rapid progress of the pathologic process in periodontal tissues and should be paid special attention to when planning the treatment strategy.
Assuntos
Doenças Cardiovasculares/fisiopatologia , Periodonto/fisiopatologia , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/enzimologia , Doença das Coronárias/complicações , Doença das Coronárias/enzimologia , Doença das Coronárias/fisiopatologia , Histocitoquímica , Humanos , Hipertensão/complicações , Hipertensão/enzimologia , Hipertensão/fisiopatologia , Microcirculação/fisiopatologia , Doenças Periodontais/enzimologia , Doenças Periodontais/etiologia , Doenças Periodontais/fisiopatologia , Periodonto/irrigação sanguínea , Periodonto/enzimologiaRESUMO
The authors had under observation 318 patients who were subjected to operation and suffered from various inflammatory diseases of the bile tract; perivesical and cholangiogenic abscesses of the liver were found in 33 of them. Bacteriological tests of the contents of the abscesses demonstrated most frequently the presence of Bacteroides fragilis as a monoculture in cholangiogenic abscesses and associations of anaerobic and aerobic bacteria in perivesical abscesses. Early operation with obligatory consideration for the anaerobic component of the microflora is recommended.
Assuntos
Infecções Bacterianas/complicações , Abscesso Hepático/etiologia , Bactérias Anaeróbias , Humanos , Pessoa de Meia-IdadeAssuntos
Periodontite/patologia , Animais , Biópsia , Doença Crônica , Tecido Conjuntivo/enzimologia , Imunofluorescência , Gengiva/enzimologia , Gengiva/patologia , Gengivite/enzimologia , Gengivite/patologia , Histocitoquímica , Humanos , Hipotireoidismo/enzimologia , Hipotireoidismo/patologia , Mandíbula/patologia , Periodontite/enzimologia , Periodonto/enzimologia , RatosAssuntos
Poluentes Atmosféricos/toxicidade , Sistema Cardiovascular/efeitos dos fármacos , Resinas Epóxi , Solventes/toxicidade , Animais , Sistema Cardiovascular/ultraestrutura , Compostos de Epóxi , Rim/irrigação sanguínea , Pulmão/irrigação sanguínea , Microcirculação/efeitos dos fármacos , Microcirculação/ultraestrutura , Microscopia Eletrônica , Ratos , Fatores de TempoRESUMO
A light and electron microscope studies of the lenses in ak/ak and +/+ mice at different stages of embryogenesis have shown that the earliest effect of the mutant gene ak at the subcellular level was the destructive change of the cell organelles in the early invaginating placode. As a result, the formation of the basal membrane of the lens placode cells and, later on, the lens capsule development were affected. The destructive changes of the cells were accompanied by a weakening of intercellular contacts and the transport of the degenerating cells into the lens vesicle cavity.
Assuntos
Afacia/genética , Genes Recessivos , Cristalino/ultraestrutura , Animais , Afacia/embriologia , Afacia/patologia , Feminino , Idade Gestacional , Homozigoto , Cristalino/embriologia , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Mutantes , Microscopia Eletrônica , GravidezAssuntos
Trifosfato de Adenosina/uso terapêutico , Dexametasona/uso terapêutico , Endotoxinas/intoxicação , Escherichia coli , Fígado/efeitos dos fármacos , Choque Séptico/tratamento farmacológico , Animais , Avaliação Pré-Clínica de Medicamentos , Feminino , Masculino , Camundongos , Ratos , Fatores de Tempo , Vitamina E/uso terapêuticoRESUMO
A study of the lenses of CatFr/+ and +/+ mice at different stages of embryonic and postembryonic development by means of electron and light microscopy has shown that the effect of CatFr gene single dose is characterized by a more rapid denucleation of lens fibers, as compared with the normal development. Defects of the nuclear envelope structure, similar with those described earlier for homozygotes, were observed in the developing lenses of heterozygotes. In CatFr/+ mice, unlike in homozygotes, the nuclei of primary lens fibers are not practically affected but those of secondary fibers are destroyed, thus leading to the lysis of these fibers and the development of cataract. The expression of CatFr gene in heterozygotes is due to additive interaction of its effects and "denucleation" process.
Assuntos
Catarata/genética , Genes Dominantes , Camundongos Mutantes/genética , Animais , Catarata/patologia , Feminino , Heterozigoto , Homozigoto , Cristalino/embriologia , Cristalino/crescimento & desenvolvimento , Cristalino/ultraestrutura , Masculino , Camundongos , Camundongos Endogâmicos A , Microscopia EletrônicaAssuntos
Doenças da Aorta/metabolismo , Arteriosclerose/metabolismo , Capilares/metabolismo , Periodonto/irrigação sanguínea , Adulto , Doença das Coronárias/metabolismo , Glicerolfosfato Desidrogenase/metabolismo , Glicogênio/metabolismo , Glicólise , Humanos , Hipertensão/metabolismo , L-Lactato Desidrogenase/metabolismo , Pessoa de Meia-IdadeAssuntos
Encéfalo/efeitos dos fármacos , Halotano/farmacologia , Coração/efeitos dos fármacos , Fígado/efeitos dos fármacos , Animais , Encéfalo/metabolismo , Avaliação Pré-Clínica de Medicamentos , Halotano/administração & dosagem , Hipóxia/induzido quimicamente , Fígado/metabolismo , Microcirculação/efeitos dos fármacos , Miocárdio/metabolismo , Oxirredução/efeitos dos fármacos , RatosRESUMO
An electron microscope study of lenses in 11--15 and 17 days old embryos of mice homozygous by dominant cataract-Fr (CatFr) gene has shown that ultrastructural changes in the nuclear envelope are the earliest expression of the mutant gene. The primary lens fibers of 12 days old embryos CatFr/CatFr, unlike those of the normal ones, are characterized by the decrease in the number of nuclear pores, evagination of the outer nuclear membrane, marked and unequal extension of perinuclear space which connects itself with the endoplasmic reticulum cisternae. In 14 days old embryos breaks in the outer nuclear membrane and evaginations in the inner one, fusion of nuclear membranes and breaks of the nuclear envelope are observed and resulted in the release of the nuclear contents with the nucleolus in the cytoplasm. Similar ultrastructural changes are characteristic also of the nuclei of secondary lens fibers at a comparable stage of differentiation. The destructive changes of nuclei are accompanied by the degeneration and autophagocytosis of cellular organelles and matrix.