1.
Radiobiologiia
; 22(4): 512-6, 1982.
Artigo
em Russo
| MEDLINE
| ID: mdl-6292992
2.
Radiobiologiia
; 16(4): 535-8, 1976.
Artigo
em Russo
| MEDLINE
| ID: mdl-996241
3.
Vopr Med Khim
; 22(4): 528-33, 1976.
Artigo
em Russo
| MEDLINE
| ID: mdl-1027239
RESUMO
A glutathione reductase activity was unaltered in thymus and liver tissue and slightly increased in spleen of rats within 15-30 min after administration of a radioprotector mercaptoethylamine. At the same time an activation of unspecific disulphide reductase occured. The both enzymes participated in spliting of mercaptoethylamine disulphides coupled with proteins. The radioprotective effectiveness of the aminothiol was, though partially, due to development of these disulfides. Retention of disulfides between the protector and cell proteins could be extended up to 1 h. by administration of mercaptoethylamine into rats with decreased content of endogenous glutathione, caused by the previous treatment with cyclohexene.
Assuntos
Dissulfetos/metabolismo , Mercaptoetilaminas/metabolismo , Proteínas/metabolismo , Protetores contra Radiação/metabolismo , Animais , Sítios de Ligação/efeitos dos fármacos , Cicloexanos/farmacologia , Estabilidade de Medicamentos , Ativação Enzimática/efeitos dos fármacos , Glutationa Redutase/metabolismo , Fígado/enzimologia , Masculino , Mercaptoetilaminas/farmacologia , Oxirredutases/metabolismo , Ligação Proteica/efeitos dos fármacos , Ratos , Baço/enzimologia , Timo/enzimologia , Fatores de Tempo
4.
Dokl Akad Nauk SSSR
; 204(4): 1006-9, 1972 Jun 01.
Artigo
em Russo
| MEDLINE
| ID: mdl-5042377