RESUMO
AIM: Secondary radiation-related side effects like secondary glaucoma (SG) of different modalities of treatment in uveal melanoma patients can appear in certain interval after therapy. This study describes the incidence of SG in patients after stereotactic radiosurgery (SRS). METHOD: The data of 230 patients treated by SRS were reviewed for SG. Group of 83 patients who were observed 5 years after treatment in one center with follow-up regularly at least 4 times per year were analyzed. RESULTS: In group of 83 patients with the median age 59 years, the median tumor volume at baseline was 0.41 cm3. The survival without SG after single dose SRS was 94 % in 1.5 year, 77 % in 2 years, 57 % in 3 years, 43 % in 3.5 years, and 18 % in 4.5 year after irradiation. In 6 patients (7.2 %) secondary enucleation was necessary due to SG. Both predictors (tumor volume and age of patient) at the time of SRS were not statistically significant by Cox proportional-hazards regression. CONCLUSIONS: Complications like SG in 5 year interval after irradiation can lead to secondary enucleation of the eye globe (Fig. 3, Ref. 44).
Assuntos
Glaucoma/epidemiologia , Melanoma/cirurgia , Aceleradores de Partículas , Lesões por Radiação/etiologia , Radiocirurgia/efeitos adversos , Radiocirurgia/métodos , Neoplasias Uveais/cirurgia , Feminino , Seguimentos , Glaucoma/etiologia , Glaucoma/fisiopatologia , Humanos , Incidência , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Eslováquia , Fatores de Tempo , Resultado do Tratamento , Carga Tumoral , Úvea/efeitos da radiação , Úvea/cirurgia , Neoplasias Uveais/patologiaRESUMO
The authors describe a female patient with bilateral colobomatous malformations of the uvea in conjunction with anorectal atresia and other symptoms suggesting Schmid-Fraccaro's syndrome called also cat eye syndrome. Using fluorescent hybridization in situ, the authors identified the supernumerous bisatellite marker chromosome derived from chromosome 22 which made it possible to confirm the suspected diagnosis.
Assuntos
Anormalidades Múltiplas , Coloboma , Úvea/anormalidades , Anormalidades Múltiplas/diagnóstico , Aberrações Cromossômicas , Cromossomos Humanos Par 22 , Feminino , Marcadores Genéticos , Humanos , Hibridização in Situ Fluorescente , Lactente , SíndromeRESUMO
The authors describe a 14-year-old patient who developed suddenly multiple milia of both upper eyelids. Histological examination revealed that eruptive cysts of folliclesvellus hair were involved. The authors present a brief review of the literature, describe the clinical and histological picture, type of heredity, differential diagnostic possibilities and method of treatment.
