[Diagnostic potential of chronoaximetric electrodiagnostics in the assessment of denervation-induced defects of m. soleus in patients with diabetic neuropathy].

The study was designed to elucidate the informative value of chronaximetry for the quantitative assessment of denervation-induced defects of m. soleus in patients with diabetic neuropathy. Conditions are clarified under which chronaximetric measurements disagree with the position of the IT hyperbola; this discrepancy lowers substantially the informative value of these characteristics as a measure of the degree of manifestation of diabetic neuropathy. The value of chronaximetry for this purpose is markedly surpassed by that of the position of the vertex of IT hyperbola. Two approaches are proposed to the simplified and exact calculation of the position of the vertex of IT hyperbola. The length of the excitation pulse obtained by these methods (CRP6 and TGT parameters) may be used, similar to chronaximetric measurements, both for the evaluation of neuropathic changes and for the choice of optimal electrostimulation technique.

Pro- and antioxidants in the central lymph in experimental chronic toxic hepatitis.

Using rat model of chronic toxic hepatitis we showed the involvement of the lymph system in the formation of the response to toxic liver damage consisting in deposition of LPO products in the central lymph and active involvement of antioxidants in their neutralization with redistribution of ceruloplasmin into lymph vessels against the background of reduced a-tocopherol content in the central lymph.

[The clinical and pharmacokinetic features of lymphotropic therapy in patients with new-onset pulmonary tuberculosis].

Regional lymphotropic therapy used in complex treatment of patients with new-onset pulmonary tuberculosis enhances its efficiency. It is well tolerated by patients and easy-to-use. The pharmacokinetic feature of isoniazid during its lymphotropic administration is its shorter elimination half-life, decreased total clearance, and a larger area under the pharmacokinetic curve.

Hepatoprotective properties of aqueous extract from Pentaphylloides fruticosa during chronic toxic hepatitis.

Hepatoprotective properties of Pentaphylloides fruticosa L. aqueous extract were studied using rat model of chronic toxic hepatitis. The preparation normalized alanine aminotransferase activity and bilirubin concentration in the plasma. Aqueous extract of Pentaphylloides fruticosa produced a protective effect on microsomal metabolism of xenobiotics and lipid peroxidation activity in the plasma and microsomal liver fraction.

[Effects of the enterosorbent SUMS-1 on isoniazid pharmacokinetics and lipid peroxidation in patients with pulmonary tuberculosis and drug-induced hepatic lesions]. / Vliianie énterosorbenta SUMS-1 na farmakokinetiku izoniazida i perekisnoe okislenie lipidov u bol'nykh tuberkulezom legkikh s lekarstvennym porazheniem pecheni.

The use of the enterosorbent SUMS-1 in the combined therapy for pulmonary tuberculosis patients with drug-induced toxic hepatic lesion arrests the clinical and laboratory manifestations of endotoxicosis, removes antibiotic intolerance, increases the elimination rate of isoniazid, and reduces its distribution scope, the area beneath the kinetic curve being unchanged. The plasma concentrations of primary products and after-products of lipid peroxidation products during enterosorbent therapy decline and the levels of ceruloplasmin and alpha-tocopherol remain unchanged.

[The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency]. / Vliianie ostroi gipoksii na farmakokinetiku antipirina i izoniazida u krys s razlichnoi rezistentnost'iu k nedostatku kisloroda.

Experiments in rats with different sensitivity to hypobaric hypoxia established bimodal distribution of antipyrine and isoniazide half-lives. Moreover, the low-sensitive rats were rapid acetylators and slow oxidizers, but the high-sensitive ones vice versa. The slowing down of antipyrine and isoniazide metabolism is supposed to be the most rational reaction of oxygen-dependent systems to the lack of oxygen in tissues.

[The characteristics of iron metabolism and the function of the transferrin-ceruloplasmin system in rats with different resistances to hypoxia]. / Osobennosti obmena zheleza i sostoianie sistemy transferrin--tseruloplazmin u krys s razlichnoi ustoichivost'iu k gipoksii.

Alterations of the same type in iron metabolism and the state of transferrin-ceruloplasmin system were demonstrated in rats with high and low sensitivity to hypoxia in acute hypobaric hypoxia. Immediately after acute hypoxia a decrease of all the parameters of ceruloplasmin and transport was demonstrated. A stimulating impact of acute hypoxia on ceruloplasmin and transferrin synthesis was observed which was most marked in low-sensitive rats on the third day after hypoxia.

[Pharmacokinetics of antipyrine, nifedipine and diazepam in experimental myocardial infarct]. / Farmakokinetika antipirina, nifedipina i diazepama pri éksperimental'nom infarkte miokarda.

It has been shown, that antipyrine, nifedipine, diazepam pharmacokinetics changes in different ways after myocardial infarction. On day 7, 14, and 21 after myocardial ischemia antipyrine T1/2 increased considerably, and antipyrine Cl and Kel decreased. Nifedipine T1/2 increased on day 7 only. There were no diazepam pharmacokinetic changes during restoration period. However, microsomal diazepam metabolism changed significantly. Diazepam hydroxylation increased on day 7 of myocardial infarction, and on day 14 and 21 did not differ from the control. Diazepam metabolites content changed considerably during restoration period. Under myocardial infarction cytochrome P-450 isoenzymes, oxidizing present substances seem to be altered to different extent.