[Epitope analysis of the hemagglutinin molecule of the Victoria lineage influenza B viruses].

A panel of five monoclonal antibodies (MAbs) to the HA1 molecule of the influenza B virus of the Victorian lineage with high virus-neutralizing activity was developed. For identification of the virus neutralizing epitopes in HA1 escape mutants (EM) of the influenza BIShandong/07/97 and B/Malaysia/2506/04 virus were selected using virus- neutralizing antibodies (MAbs). Three EMs had single, two--double and one--triple amino acid substitutions (AAS) in HA1 (H122N, A202E, K203T, K2031, K203N or A317V). In addition, AAS N197S was detected in three EMs. A correlation of AAS identified with peculiarities of interaction of EMs with Mabs was discussed.

[Immediate results of combined treatment for soft tissue sarcomas including intraoperative radiation therapy].

Nowadays the most popular and justified, from oncological positions, method of treatment for soft tissue sarcomas is a combined approach with the use of conservative surgery followed by postoperative radiation therapy. In this regard, intraoperative radiation therapy (IORT) in a single dose of 10-20 Gy is a method that optimizes the role of radiation therapy in treatment of this pathology allowing precise localization of radiation zone within the "tumor bed", thereby minimizing damage of normal tissues and critical organs. The aim of the study was to investigate the effect of IORT on the frequency and structure of post-operative complications. Testing group (n = 49) was compared to the group without IORT (n = 57) and group with only surgery (n = 171). According to the study it was not obtained statistically significant differences in the incidence of postoperative complications in the groups (p = 0,57), not marked influence on the structure of post-operative complications.

[Results of combined treatment with intraoperative radial therapy of soft tissue sarcoma].

The intraoperative radiation therapy (IORT) in combined therapy of soft tissue sarcoma in a single dose 10-20 Gy is the method, which can optimize the role of radiation therapy in treatment of this nosology. This method allows exact localization of the irradiation zone in the frames of "tumor bed", thereby minimizing the damage of normal tissues and critical organs. The aim of the study was the influence of IORT on the rate and structure of postoperative complications and long-term results of treatment in the group under study (n = 49) in comparison with the group of combined treatment without IORT (n = 57) and the group of surgical treatment. No statistically reliable difference in the rate of postoperative complications in groups (p = 0.57) was obtained and there was no influence on the structure of postoperative complications. At the same time the statistically reliable increase of general survival rates (p = 0.025) and the survival without relapse in the main group (p < 0.025) were obtained. Thus, the application of IORT in combined treatment of soft tissue sarcomas showed the satisfactory profile of "surgical safety", provided the reliable increase of general survival rates and rates without relapse.

[In vitro development of the reconstructed embryos of cattle activated after various electrofusion times].

The dynamics of in vitro development of reconstructed embryos of cattle after various electrofusion times was studied. The in vitro mature oocytes without zona pellucida enucleated using the touch method were taken as cytoplasts. Fetal fibroblasts were used as the nuclei source. Approximately 40% of embryos activated between 3 and 3.2 hours after electrofusion developed to blastocysts. The effectiveness of in vitro cloned embryo development did not decrease when the time between electrofusion and activation was extended up to 4-5 hours. The pattern of more successful development of in vitro reconstructed embryos was found using enucleated oocytes, excreting the first polar body after 18 hours in comparison with oocytes matured in vitro afterwards, as cytoplasts.

[Expanded D2 lymphodissection in combined treatment of gastric cancer: unification of treatment approaches].

The authors present an analysis of results of using D2 operations in combined treatment of gastric cancer. Such volumes of operations combined with preoperative irradiation are not followed by greater number of complications and lethality. The incidence of progressing in terms more than a year proved to be considerably lower in the group of patients with combined treatment with D2 lymphodissection than in the groups without lymphodissection and preoperative radiation therapy.

[Preoperative radiotherapy and extended surgical procedures for stomach cancer--assessment of safety of the combined approach].

Immediate results of D-2 surgery for stomach cancer are presented. No significanty was reported during combination therapy including preoperative gammatherapy 2) a rise in complication incidence or lethality. Hence, D-2 surgery is a safe antitumor procedure.

[Study with a quartz resonator of a new natural informational channel associated with quantum properties of the physical space (vacuum)]. / Experimental'nye issledovaniia novogo informatsionnogo kanala v prirode, obuslovlennogo kvantovymi svoistvami fizicheskogo prostranstva (vakuuma) s pomoshch'iu kvartsevogo rezonatora.

The results on long-time measurements of differential frequency of two quartz generators are presented. One generator is placed into magnetic system creating a vector potential field, and the other (calibration generator) is situated out of this system. It was found that oscillations of frequency difference occur with periods to 20 h and 22.5 h were revealed. Tangents to the Earth parallel at the moments of observation of value minima form three distinct subsets of directions. The traditional physical concepts do not explain these results. These results are in a good agreement with hypothesis about the anisotropic interaction of objects in nature (due to the new fundamental vector constant, cosmological vector potential Ag) and hence a new informational channel. The possibility is discussed that external factors affect biological objects via the new information channel.