Unusually high creatine kinase in a case of rhabdomyolysis without acute kidney injury: a case report.

Background: While rhabdomyolysis frequently leads to hospital admissions, typically following trauma, recurrent occurrences are relatively rare, accounting for just 10% of cases. For young patients experiencing repetitive episodes without an apparent cause, a comprehensive investigation into the possible etiologies is crucial. Recognizing the atypical nature of recurrent rhabdomyolysis is crucial and a thorough workup encompassing evaluations for potential endocrine, inflammatory, and metabolic etiologies is recommended. Additionally, acute kidney injury is a common complication with severe rhabdomyolysis, hence early recognition and intervention is crucial. Case Description: Herein we present a case of a 30-year-old young African American male patient with recurrent rhabdomyolysis with the highest ever reported creatine kinase (CK) to our knowledge. A notable aspect of this case is the surprising absence of acute kidney injury, despite the severity of CK elevation. We also delve into the extensive workup done for rhabdomyolysis of unclear etiology. Conclusions: Our case underscores the importance of looking into non-traumatic factors behind recurrent rhabdomyolysis, especially in young patients. We also stress the significance of early detection and intervention, showcasing the potential to prevent acute kidney injury even in the presence of markedly elevated CK levels. Timely recognition and appropriate management can prove instrumental in mitigating the severity of complications associated with rhabdomyolysis.

A case of culture-negative endocarditis causing flail perforated mitral valve.

We describe a case of culture negative endocarditis causing mitral valve perforations and recurrent heart failure admissions.

A Case of Sinus of Valsalva Aneurysm Rupture Causing Cardiogenic Shock.

A sinus of Valsalva aneurysm (SVA) is an abnormal dilation between the aortic valve annulus and sinotubular junction resulting from weakness in the elastic lamina. In the vast majority of cases, SVAs are asymptomatic and are incidentally detected on echocardiogram imaging. In some cases, they can rupture and lead to an intracardiac shunt. Sudden rupture of a high-flow aneurysm can lead to significant hemodynamic compromise and a high fatality rate if not diagnosed early and intervened upon. We present the case of a 68-year-old male who presented with symptoms of heart failure and later rapidly deteriorated due to a sudden spontaneous rupture of the SVA leading to cardiogenic shock. In our case, timely identification and intervention led to a good outcome for our patient. We also present echocardiogram images and videos to educate the readers further about diagnosing SVA. With this case report, we would like to help clinicians and researchers expand their understanding of the condition and treatment outcomes.

A Rare Case of Mycotic Aneurysm Due to Methicillin-Sensitive Staphylococcus aureus (MSSA) Bacteremia.

Mycotic aneurysm is defined as an infection of the arterial wall either by fungi or bacteria. Although, a rare complication of infection, it is associated with high morbidity and mortality. We describe a 69-year-old female with a rare thoracic aortic mycotic aneurysm, with no clear source of infection and a predominantly atypical presentation, manifesting primarily as heart failure, at a rural community hospital. Our case also depicts the rapid development of aortitis and mycotic aneurysms. This case highlights the challenges in the diagnosis and management of this condition.

COVID-19 Bullous Lung Disease Superinfection by Raoultella planticola.

Bullous lung lesions from coronavirus disease 2019 (COVID-19) pneumonia, causing pneumothorax, are a rare complication, affecting up to 1% of infected patients. Raoultella planticola is an aerobic, gram-negative bacteria known to cause opportunistic infection. We present a rare case of spontaneous pneumothorax from rupture of lung bulla as a late sequela from COVID-19 pneumonia and superinfection of the bulla by R. planticola. Although superinfection of bullous lesions is known, this is the first reported case of R. planticola pneumonia in a patient with COVID-19 lung bullae. COVID-19 patients are at heightened risk for bullous lung lesions and superinfection by opportunistic organisms; thus, they should be followed up closely.

Severe Refractory Hypocalcemia Caused by Denosumab.

Denosumab is a fully human monoclonal antibody that binds to the receptor activator of nuclear factor kappa-Β ligand, an essential cytokine factor in bone resorption, which reduces bone resorption and has been shown to decrease the incidence of skeletal-related events in patients with malignancy and bone metastasis. Severe hypocalcemia is a rare and life-threatening adverse effect of denosumab therapy. Here, we discuss the case of a patient with stage 4 estrogen receptor-positive, progesterone receptor-negative, human epidermal growth factor receptor 2-negative breast cancer who was on treatment with denosumab for bony metastases and presented with severe refractory hypocalcemia.