[Oxidase activity of ceruloplasmin and the state of hemocoagulation in patients with chronic pancreatitis]. / Oksidaznaia aktivnost' tseruloplazmina i sostoianie gemokoaguliatsii u bol'nykh khronicheskim pankreatitom.

We examined oxidase activity of ceruloplasmin, fibrinogen content in the blood serum and the state of hemocoagulation in 80 patients with chronic pancreatitis of different etiology. The presence of ceruloplasmin was considered to be paraphenylenediamine oxidase. It was shown that at the acute stage of the disease oxidase activity of ceruloplasmin is increased and depends on the severity, duration and presence of complications. An increase of the anti-oxidant action protein content is accompanied by hypercoagulation and an increase of the fibrinogen content. Data are given on the availability of correlation relationship between the fibrinogen content and general blood coagulation constant.

[Features of composition of bile acids in duodenal bile in patients with chronic pancreatitis]. / Osobennosti sostava zhelchnykh kislot v duodenal'noi zhelchi bol'nykh khronicheskim pankreatitom.

A number of conditions contributing to changes in metabolism of bile acids (BA) appears in case of chronic pancreatitis (CP). There was a study of particular features of the BA composition in the bile of 20 patients with CP and 10 donors with the help of the thin-layer chromatography method. The first group consisted of patients with alcoholic pancreatitis (AP) at the acute stage of the disease, and the second one consisted of patients with chronic biliary pancreatitis. A substantial increase in the content of conjugated BA was recorded in the bile of AP patients. The dependence of changes of bile secretion and its content on the duration of the disease was established. A reduction of bile secretion and decrease in the content of conjugated BA and cholesterol therein were recorded in the second group of patients. A particular feature of the BA composition was a decrease in the percentage of conjugates of cholic acid and glycodioxicholan acids. Cholic acid prevailed among free BAs. The lithocholic acid content increased depending on the duration and severity of the disease. Possible reasons of cholesterol deficit and high free cholic acid content in the bile of CP patients were noted. The findings indicate a colloidal stability of the bile in case of CP. An abnormal conjugation of BAs with glycine and especially with taurine can be not only the reason for changes in the qualitative BA composition but can also lead to changes in absorption of exogenous cholesterol. These changes are most apparent in patients with biliary-dependent forms of pancreatitis.

[Stomach mucosa prostaglandins in liver cirrhosis]. / Prostaglandiny slizistoi obolochki zheludka pri tsirroze pecheni.

Distinct decrease in content of prostaglandins PGE, PGF2 alpha and 6-keto-PGF1 alpha was detected in biopsy material, using radioimmunoassay, from gastric mucosal membrane of patients with liver tissue cirrhosis complicated and not complicated by ulcerous disease of stomach or duodenum which correlated with a decrease in secretion of gastric juice (basal and histamine-stimulated secretion). These data suggest considerable impairments of endogenous biosynthesis of prostaglandins in gastric mucosal membrane under conditions of liver tissue cirrhosis, which are of importance in development of ulcerous disease in these patients.

[Role of gastric mucosa prostaglandins in the development of ulcer lesions in liver cirrhosis]. / Rol' prostaglandinov slizistoi obolochki zheludka v razvitii iazvennykh porazhenii pri tsirroze pecheni.

The amount of prostaglandins (PD) E, F2 alpha and I2 (measured as 6-keto-Pg F1 alpha) in endoscopic biopsy specimens of gastric corpus' mucosa also as the concentration of Pg E and F2 in gastric juice of cirrhotic patients without or with gastric and duodenal ulcer were measured by radioimmunoassay. Release of Pgs with gastric juice (in the basal state and after histamine stimulation) was also significantly less in these patients. It was concluded that the severe disturbance of endogenous biosynthesis Pgs in gastroduodenal mucus of cirrhotic patients may play an important role in the development of ulcer disease in these patients.