Age, temperature, and parasitaemia predict chloroquine treatment failure and anaemia in children with uncomplicated Plasmodium falciparum malaria.

The prevalence of chloroquine-resistant Plasmodium falciparum malaria has been increasing in sub-Saharan Africa and parts of South America over the last 2 decades, and has been associated with increased anaemia-associated morbidity and higher mortality rates. Prospectively collected clinical and parasitological data from a multicentre study of 788 children aged 6-59 months with uncomplicated P. falciparum malaria were analysed in order to identify risk factors for chloroquine treatment failure and to assess its impact on anaemia after therapy. The proportion of chloroquine treatment failures (combined early and late treatment failures) was higher in the central-eastern African countries (Tanzania, 53%; Uganda, 80%; Zambia, 57%) and Ecuador (54%) than in Ghana (36%). Using logistic regression, predictors of early treatment failure included younger age, higher baseline temperature, and greater levels of parasitaemia. We conclude that younger age, higher initial temperature, and higher baseline parasitaemia predict early treatment failure and a higher probability of worsening anaemia between admission and days 7 or 14 post-treatment.

Age of male circumcision and risk of prevalent HIV infection in rural Uganda.

OBJECTIVE: To assess whether circumcision performed on postpubertal men affords the same level of protection from HIV-1 acquisition as circumcisions earlier in childhood. DESIGN: Cross-sectional study of a population-based cohort. SETTING: Rakai district, rural Uganda. METHODS: A total of 6821 men aged 15-59 years were surveyed and venous blood samples were tested for HIV-1 and syphilis. Age at circumcision was dichotomized into men who were circumcised before or at age 12 years (prepubertal) and men circumcised after age 12 years (postpubertal). Postpubertal circumcised men were also subdivided into those reporting circumcision at ages 13-20 years and > or = 21 years. RESULTS: HIV-1 prevalence was 14.1% in uncircumcised men, compared with 16.2% for men circumcised at age > or = 21 years, 10.0% for men circumcised at age 13-20 years, and 6.9% in men circumcised at age < or = 12 years. On bivariate analysis, lower prevalence of HIV-1 associated with prepubertal circumcision was observed in all age, education, ethnic and religious groups. Multivariate adjusted odds ratio of prevalent HIV-1 infection associated with prepubertal circumcision was 0.39 [95% confidence interval (CI), 0.29-0.53]. In the postpubertal group, the adjusted odds ratio for men circumcised at ages 13-20 years was 0.46 (95% CI, 0.28-0.77), and 0.78 (95% CI, 0.43-1.43) for men circumcised after age 20 years. CONCLUSIONS: Prepubertal circumcision is associated with reduced HIV risk, whereas circumcision after age 20 years is not significantly protective against HIV-1 infection. Age at circumcision and reasons for circumcision need to be considered in future studies of circumcision and HIV risk.

Legislatory framework for private medical practice in Uganda.

BACKGROUND: In Uganda the private health sector has expanded dramatically in recent years with a striking proliferation of facilities for private medical practice which is particularly evident in urban areas. OBJECTIVES: The general objective of this study was to analyse the laws and regulations governing the private health sector in order to determine how they affect the operations and development of private medical practice in Uganda. METHODS: Between December 1995 and December 1996, we identified and reviewed all the laws, which affect private medical practice in Uganda. We discussed the contents of the laws with Ministry of Health officials and with representatives of private practitioners. We also made visits to a sample of clinics, which we inspected to ascertain compliance with the laws, and held interviews with managers of the clinics to get their views about the laws. RESULTS: Two categories of laws were identified. The first category includes two laws adopted in 1993, whose purpose is to ensure the availability at all times of efficacious and cost effective drugs in the country. The second category includes three laws, all adopted in 1996, which spell out the licensing procedures, supervision, disciplining and general control of different categories of professionals. The list of health professions, which are permitted to practice privately, was revised to include new categories, which were previously not allowed. We identified what we considered to be barriers to private health sector development, loopholes in the laws and also assessed the enforcement of the laws. The legal barriers include restrictions of drug imports, the requirement for the professionals to renew their practising licenses and to register the premises annually at one central place in the country, long periods of time mandated for acquiring experience before one can be permitted to practice privately and the finding that there are some capable professions which are still not allowed to practice privately. CONCLUSION: We made recommendations to the Ministry of Health to address all these barriers. We also recommended to the Ministry that non-professionals who have the ability to set up clinics should be allowed to register them provided they can engage professionals to operate them.

Trends in HIV-1 prevalence may not reflect trends in incidence in mature epidemics: data from the Rakai population-based cohort, Uganda.

OBJECTIVES: To assess whether trends in serial HIV-1 prevalence reflect trend in HIV incidence, and to decompose the effects of HIV-1 incidence, mortality, mobility and compliance on HIV-1 prevalence in a population-based cohort. DESIGN: Two-year follow up (1990-1992) of an open cohort of all adults aged 15-59 years, resident in a sample of 31 representative community clusters in rural Rakai District, Uganda. METHODS: A detailed household enumeration was concluded at baseline and in each subsequent year. All household residents were listed, and all deaths and in- and out-migrations that occurred in the intersurvey year wee recorded. In each year, all consenting adults were interviewed and provided a serological sample; 2591 adults aged 15-59 years were enrolled at baseline. RESULTS: HIV prevalence among adults declined significantly 1990 and 1992 (23.4% at baseline, 21.8% in 1991, 20.9% in 1992; P < 0.05). Declining prevalence was also observed in subgroups, including young adults aged 15-24 years (from 20.6 to 16.2% over 3 years; P < 0.02), women of reproductive age (from 27.1 to 23.5%; P < 0.05), and pregnant women (from 25.4 to 20.0%; not significant), However, HIV incidence did not change significantly among all adults aged 15-59 years (2.1 +/- 0.4 per 100 person-years of observation (PYO) in 1990-1991 and 2.0 +/- 0.3 per 100 PYO in 1991-1992], nor in population subgroups. HIV-related mortality was high (13.5 per 100 PYO among the HIV-positive), removing more infected persons that were added by seroconversion. Net out-migration also removed substantial numbers of HIV-positive individuals. CONCLUSIONS: In this mature HIV epidemic, HIV prevalence declined in the presence of stable and incidence. HIV-related mortality contributed most to the prevalence decline. Prevalence was not an adequate surrogate measure of incidence, limiting the utility or serial prevalence measures in assessing the dynamics of the HIV epidemic and in evaluating the impact of current preventive strategies.

PIP: Findings are reported from a 2-year follow-up study of an open cohort of people aged 15-59 years living in a sample of 31 representative community clusters in rural Rakai district, Uganda, to measure whether trends in serial HIV-1 prevalence reflect trends in HIV incidence, and to gain insight into the effects of HIV-1 incidence, mortality, mobility, and compliance upon HIV-1 prevalence. In each year of study, all consenting adults provided a serological sample and were interviewed; 2591 adults were enrolled at baseline. HIV prevalence among adults declined significantly between 1990 and 1992; from 23.4% in 1990, to 21.8% in 1991, and 20.9% in 1992. Declining prevalence was also observed in subgroups, including young adults aged 15-24 years from 20.6% to 16.2%, reproductive-age women from 27.1% to 23.5%, and pregnant women from 25.4% to 20.0%. The decline in HIV prevalence among pregnant women, however, is not significant. HIV incidence did not change significantly among all adults aged 15-59 years, nor in population subgroups. HIV-related mortality was 13.5/person-year of observation among those who were HIV-positive. Substantial numbers of HIV-infected individuals were also loss to emigration.

Trends in attitudes and behaviour relevant to AIDS in Ugandan community.

Behaviour-related preventive measures are still the main weapon against the spread of AIDS. Intensive AIDS prevention and control activities conducted over the last ten years need to be evaluated on the basis of their impact on attitudes and behaviour relevant to AIDS. The main objective of this study was to document and evaluate trends in attitudes and behaviour relevant to AIDS in a Ugandan community over a seven year follow up period. The study was a longitudinal community-based closed cohort. Periodic surveys were conducted on the study group and data on condom use, attitudes about condoms, rates of sexual partner change and reported frequency of sexually transmitted diseases were collected in all surveys. Data reported are from surveys conducted during 1987, 1992 and 1994 in which similar questions were asked and emerging trends identified. Reported condom use ever, increased from 3.9% in 1987 to 10.1% in 1992 and to 27.2% in 1994. This is a 7.3 fold increase over seven years. In females, reported use of condoms increased from 1.2% in 1987 to 18.2% in 1994 while in males it increased from 6.9% to 35.3% over the same period. In this study group there are still more people opposed to the ongoing intensive condom campaign than there are those supporting it. The percentage supporting the campaign was 28% in 1987, 26% in 1992 and 40.8% in 1994. This is a rising trend. The rate of sexual partner change has declined. During the baseline survey, 26.5% of the respondents reported that they had intercourse with two or more sexual partners in the six months period before the interview. This proportion decreased to 6.8% in 1992 but then increased to 17.1% in 1994. During the baseline survey, 2.6% of the study group reported that they had sexual intercourse with six or more partners during the six months period before the interview but during the 1992 and 1994 surveys, no one reported sexual intercourse with more than five partners during a similar period. The reported frequency of sexually transmitted diseases during a twelve month recall period, reflecting STD incidence, decreased from 3.5% in 1992 to 1.9% in 1994. In conclusion during the seven year followup period of this community-based closed cohort, we have identified a sharp increase in condom use, a reduced rate of sexual partner change and a decline in the reported frequency of sexually transmitted disease. The percentage of people supporting the condom campaign is rising. These are some of the outstanding outcomes of the AIDS prevention activities conducted in the country over the last 10 years.

PIP: Over the past decade, the Government of Uganda has implemented health education campaigns aimed at preventing the further spread of HIV infection and AIDS. A 7-year (1987-94) longitudinal closed cohort study (n = 1990) conducted in Kasangati evaluated the impact of these campaigns on condom attitudes and use, rates of sexual partner change, and sexually transmitted disease (STD) incidence. Kasangati is a semirural subcounty north of Kampala. Most encouraging was a 7.3-fold increase in condom use over the 7-year study period. Ever use of condoms rose from 4% in 1987 (baseline) to 10% in 1992 and to 27% in 1994. Support for campaigns that urge condom use outside of regular relationships rose from 28% in 1987 to 26% in 1992 and to 40.8% in 1994. The proportion of respondents reporting 2 or more sexual partners in the previous 6 months fell from 26.5% in 1987 to 6.8% in 1992, then increased to 17.1% in 1994. It is unclear whether the higher rate of sexual partner change in 1994 than 1992 represents an underreporting in 1992 or is related to increased rates of condom use. In the 1987 survey, 20.2% of respondents reported an STD episode in the preceding 5 years. In 1992 and 1994, when the recall period was reduced to 12 months before the survey, these rates were 3.5% and 1.9%, respectively. The numerous AIDS prevention campaigns in Uganda, combined with easier access to condoms, appear to have had a significant impact on AIDS-related attitudes and behaviors in Uganda.

Adolescents, sexual behaviour and HIV-1 in rural Rakai district, Uganda.

OBJECTIVES: To describe the epidemiology of HIV-1 infection among adolescents aged 13-19 years, in rural Rakai district, Uganda. STUDY DESIGN: Baseline survey and 2-year follow-up (1990-1992) of adolescents in a population-based, open rural cohort. METHODS: Annual enumeration and behavioral/serological survey of all consenting adolescents aged 13-19 years at recruitment, residing in 31 randomly selected community clusters. RESULTS: At baseline, of 909 adolescents present in study clusters, 824 (90.6%) provided interview data and serological samples. No adolescents aged 13-14 years were HIV-infected. Among those aged 15-19 years, 1.8% of men and 19.0% of women were HIV-positive. Among young women aged 15-19 years in marital/consensual union, 21.3% were HIV-positive; this rate did not differ significantly from the 29.1% prevalence in those reporting non-permanent relationships; prevalence was significantly lower in women reporting no current relationship (4.3%). After multivariate adjustment, female sex, age 17-19 years, residence in trading centers/trading villages and a history of sexually transmitted disease symptoms remained significantly associated with HIV infection. Seventy-nine per cent of adolescents provided a follow-up serological sample. No young men aged 13-14 years seroconverted during the study; in young women aged 13-14 years, HIV seroincidence was 0.6 per 100 person-years (PY) of observation. Among young men aged 15-19 years, there were 1.1 +/- 0.6 seroconversions per 100 PY of observation prior to age 21 years; among women 15-19 years, the incidence rate was 3.9 +/- 1.0 per 100 PY of observation prior to age 21 years. The mortality rate among HIV-positive adolescents aged 15-19 years, at 3.9 per 100 PY of observation, was 13-fold higher than that among the HIV-uninfected. By 1992, knowledge of sexual transmission was almost universal, the proportions reporting multiple partners had decreased and condom use had increased over baseline. CONCLUSIONS: Adolescents, and young women in particular, are vulnerable to HIV infection. Despite reported behavioral changes, HIV incidence rates remain substantial, and there is a need for innovative HIV preventive measures.

Adolescent sexual networking and HIV transmission in rural Uganda.

Information on 861 adolescents shows that in 1991 36 per cent reported having been sexually active in the previous 12 months, but only 6.2 per cent had ever used a condom (11% males, 2.4% females). The HIV infection rate was 5.9 per cent overall, 0.8 per cent in males and 9.9 per cent in females. The proportion sexually active and the rate of HIV infection rise with age. The annual incidence of HIV infection was 2.0 per 100 person-years of follow-up among all adolescents, 0.8 in males and 3.0 in females. The annual mortality rate among HIV-negative adolescents was 0.37 per cent versus 3.92 per cent among the HIV-positive adolescents, a rate ratio of 10.6. Sexual network data were collected on 389 adolescents aged 15-19 years of whom 55 per cent were sexually active. The median age of first sexual intercourse was 15 years in either sex. The 214 adolescents reported 339 sexual relationships of which 38.5 per cent were with spouses, 36 per cent with boy or girl friends and 21 per cent with 'friends'. There were 52 concurrent sexual relationships reported by 35 adolescents. Males report higher rates of concurrent sexual relationships than females. The sexual partners of boys were mainly younger students and housemaids while the girls' partners were mainly older traders and salaried workers. Adolescents in this community report high rates of sexual activity and have complex sexual networks. They probably are important in the dynamics of HIV infection.

PIP: Interview and HIV serostatus data were obtained for 861 adolescents aged 13-19 years in 1991 living in Rakai district, Uganda. Although 36% reported having been sexually active during the previous 12 months, only 11% of males and 2.4% of females had ever used a condom. 0.8% of males and 9.9% of females were infected with HIV. The proportion of adolescents who are sexually active and the rate of HIV infection both increase with age. The annual incidence of HIV infection was 2.0 per 100 person-years of follow-up among all adolescents, 0.8 in males and 3.0 in females. The annual mortality rate among HIV-negative adolescents was 0.37% compared to 3.92% among the HIV-positive adolescents. Sexual networking data were collected from 389 adolescents aged 15-19 years of whom 55% were sexually active. The median age at first sexual intercourse was 15 years for both boys and girls. The 214 sexually active adolescents reported 339 sexual relationships of which 38.5% were with spouses, 36% with boyfriends or girlfriends, and 21% with friends. 52 concurrent sexual relationships were reported by 35 adolescents, with males reporting higher rates of concurrent sexual relationships than females. Boys' sex partners were mainly younger students and housemaids while the girls' partners were mainly older traders and salaried workers.

The social dynamics of HIV transmission as reflected through discordant couples in rural Uganda.

OBJECTIVE: To describe the role of men and women as sources of HIV transmission and to estimate HIV incidence among discordant couples resident in diverse rural communities in Uganda. SETTING: Rakai, a rural district in Uganda, East Africa. METHODS: A population-based cohort study, which has been conducted as annual serological and behavioral surveys since 1989. Community clusters were stratified into trading centers on main roads, intermediate trading villages on secondary roads and agricultural villages off roads. In the 1990 survey round, serological data were available for 79 discordant and 411 concordant HIV-negative couples aged 13-49 years. The present analysis examines sex-specific seropositivity associated with place of residence and the incidence of seroconversion among discordant couples between 1990 and 1991. RESULTS: Seventy-nine discordant couples were followed; the HIV-positive partner was male in 44 couples (57%) and female in 35 couples (43%). There was marked variation in the sex of the seropositive partner by place of residence: women were the HIV-positive partner in 57% of couples from trading centers, 52% from intermediate villages, and 20% from agricultural communities (P < 0.008). Condom use was higher in discordant couples in which the man was the uninfected partner (17.1%) rather than the woman (9.5%). HIV-positive women, but not HIV-positive men, reported significantly more sexual partners and more genital ulcers than seronegative individuals of the same sex. Seroincidence rates among men and women in discordant relationship were 8.7 and 9.2 per 100 person-years (PY), respectively, which was much higher than in concordant seronegative couples (men, 0.82; women, 0.87 per 100 PY). CONCLUSIONS: In this Ugandan population, men are the predominant source of new infections in rural villages. Risk factors and preventive behaviors vary with the sex of the infected partner, and seroconversion rates are similar in both sexes.

PIP: The analysis of marital relationships in rural Uganda in which one partner is infected with human immunodeficiency virus (HIV) revealed important information about the social dynamics of HIV transmission. As part of an ongoing cohort study of over 3000 adults in southwestern Uganda's Rakai district, data were collected on 79 discordant couples. The HIV-infected partner was male in 44 couples (57%) and female in 35 couples (43%). In the trading centers and intermediate trading villages, women were more likely to be the HIV-infected partner (57% and 52%, respectively); in rural areas, however, the male partner was the HIV carrier in 80% of discordant couples. 14.3% of women in female HIV-positive compared to only 2.1% of those in male HIV-positive discordant relationships reported two or more sexual partners in the year preceding the interview; there was no significant difference on this factor among HIV-positive and HIV-negative men (48.8% and 45,7%, respectively). 17.1% of seronegative men with HIV-infected wives compared to only 9.5% of seropositive men with seronegative wives used condoms with their partner. During the one-year study period, the rate of seroconversion was 8.7/100 years of observation for men and 9.2 for women. Extrapolation of the data from this study to the district as a whole suggests that 18.7% of couples have at least one HIV-infected member. Needed are campaigns to promote monogamy and condom use, particularly among men from rural areas who travel to high prevalence trading areas.

The declining HIV seroprevalence in Uganda: what evidence?

PIP: Papers presented at the Ninth International Conference on AIDS and STDs in Africa, held in Kampala in December 1995, indicate that HIV prevalence has been declining in several sectors of the population in Uganda over the past few years. This paper reviews the following relevant presentations: studies among pregnant women in Mulago hospital, Kampala; sentinel surveillance data; a community-based study of HIV in Masaka district; a community-based study in Rakai district; and persons attending voluntary HIV testing in towns in Uganda. Most of the data presented come from urban areas. Approximately 90% of the country's population, however, lives in rural areas. All of the studies document declining trends in HIV prevalence in the populations studied. The author considers whether these findings represent what is happening in the general population and what is behind this trend. On the basis of the presentations made during the conference, it seems that the main factors affecting current HIV seroprevalence trends in Uganda are HIV incidence, HIV-related mortality, and demographic changes. The role of each of these factors is discussed in light of the available evidence. More specifically, there appears to be a real decline in HIV seroprevalence in some population groups in Uganda. Very high HIV-related mortality, the movement of many young people into the adult demographic category while retaining their HIV-negative status, and probably a lower HIV incidence rate than that prevailing before 1990 are some of the explanations for the observed trend.^ieng

Incidence of HIV-1 infection in a rural region of Uganda.

OBJECTIVE: To determine the incidence of infection with HIV-1 and the risk factors associated with seroconversion in three geographical strata of a rural Ugandan district. DESIGN: Serological, sociodemographic, and behavioural surveys of everyone aged 13 or more in 21 randomly selected communities at baseline and one year later. SETTING: Rural population of Rakai district, southwestern Uganda, residing in main road trading centres, secondary trading villages, and agricultural villages. SUBJECTS: In 1989, 1292 adults provided a blood sample and interview data; one year later, 778 survivors (77%) who had been seronegative at baseline provided follow up data. MAIN OUTCOME MEASURES: Incidence of HIV infection in relation to individual characteristics and risk factors, including place of residence. RESULTS: Incidence of HIV infection in all adults was 2.1/100 person years of observation (SE 0.5 (95% confidence interval 1.1 to 3.1)); in people aged 15-39 the incidence was 3.2/100 person years. Incidence was highest in men and women aged 20-24 (9.2/100 person years (3.9) and 6.8/100 person years (2.9) respectively). Risk factors significantly associated with seroconversion were age 24 and under and two or more sexual partners. Between the surveys the proportion of all respondents reporting high risk behaviour (two or more partners) significantly increased from 8.9% to 12.3%. CONCLUSIONS: Despite preventive programmes and substantial knowledge about AIDS the incidence of HIV infection remains high in this rural population. Prevention aimed at vulnerable rural communities is urgently needed to contain the HIV epidemic.

PIP: In 1990, researchers followed up on as many of the 1292 adults they surveyed in 1989 as they who lived in rural Rakai district in southwestern Uganda to determine HIV-1 incidence and the risk factors associated with seroconversion. They were only able to follow up on 774 of the 1037 adults who were HIV-1 seronegative in 1989. In 1989, knowledge about AIDS and about sexual intercourse as a mode of HIV transmission was high (94% and 86%, respectively). The 1989 HIV-1 seroprevalence rate ranged from 38.5% in trading centers to 8.6% in agricultural villages off main and secondary roads. 21 (2.7%) had seroconverted (incidence = 2.1/100 person years). Since the researchers oversampled in trading centers, they estimated the weighted seroincidence to be 1.9%. HIV-1 seroconversion peaked in the 20-24 year old age group with it being greater in men than in women (9.2% vs. 6.8%). The most significant risk factor for seroconversion was number of sexual partners (8.3% for 2 or more partners vs. 2.5% for 0-1 partners; rate ratio = 3.4; p .01 for trend). The risk of seroconversion for someone with just 1 sexual partner was high (2.8%), reflecting the high HIV-1 seroprevalence in Rakai district. The percentage of subjects with at least 2 sexual partners rose from 8.9% in 1989 to 12.3% in 1990. Seroconversion was not associated with injections. No one had had a blood transfusion. Attendance at a 1989 AIDS education rally did not affect HIV seroconversion. In fact, it was greater among people attending the rally (3.5% vs. 2.1%). Logistic regression revealed that age and numbers of partners were the only significant factors affecting seroconversion (odds ration [OR] for 15-24 years compared to 25-39 years was 3.9 and OR for 2 or more sexual partners was 6.5). These findings indicated that existing HIV/AIDS education programs do not reduce HIV transmission and that better strategies are needed.

The effect of AIDS on manpower resource development in Uganda

A restrospective investigation of mortality among Uganda's highly trained manpower was carried out in 1990. It was found that the mortality rate in this category had increased from 0.4per year during the pre-AIDS period to 2.5per year by 1990. This increase was largely attributable to AIDS. These findings show that AIDS is causing big losses in training investment in Uganda

The impact of AIDS in a rural Ugandan community.

Three AIDS related surveys have been conducted on a community based cohort in the Kasangati defined area, Uganda, during 1987, 1990 and 1992. The 1987 baseline survey recruited 1990 adults, and in addition to assessing levels of knowledge, attitudes and practices, HIV serology was done on all the study participants. During the 1992 survey, our objectives were threefold: (i) to assess the attitudes and behaviours relevant to AIDS and to evaluate the magnitude of any changes since 1987, (ii) to assess the socioeconomic impact of AIDS and, (iii) to assess the effect of AIDS on the mortality trends in the area. It was found that the percentage of people who had ever used a condom increased from 4% in 1987 to 10% in 1992, but those who used condoms frequently remained the same at 1%. Sexual partner change was measured over a six month period and the percentage of people who had two or more sexual partners in this period was found to be 7% in 1992 compared to 26.4% in 1987. The five year mortality rate among the persons initially HIV positive was 44.7% compared to 8.7% among those initially sero-negative. AIDS has substantially increased the mortality rate in this community leading to reduced incomes for the families of persons dying from the disease, increased expenditure on medical treatment, and a new breed of orphans. The overall five year mortality rate was 10.6% (128/1204) but if the persons reported to have died from AIDS are excluded it is only 6.1% (73/1204).

Focus group interviews about AIDS in Rakai District of Uganda.

Focus group interviews about AIDS were held in Rakai district, Uganda during early 1990 with groups from various sections of the community. It was found that the knowledge of AIDS symptoms and its transmission were widespread. Attitudes regarding many aspects of sexual behavior, AIDS patients, condoms, injections, hospital treatment, sexually transmitted diseases and an AIDS cure were investigated. We found that most people no longer fear casual contact with AIDS patients but they blame spouses of people with AIDS for spreading the infection. Condoms are generally not trusted. Many people feel that condoms cannot prevent transmission of the AIDS virus and some fear that they may get torn and cause complications in women. Most people now do not like injections for treatment and when necessary, prefer disposable needles and syringes. Hospital treatment for AIDS patients is not trusted very much, and many people believe that AIDS patients are intentionally killed off by doctors. Sexual behavior was extensively discussed and it was found that there is generally a reduced level of multiple sexual partners. The reduction is more marked in rural areas but the urban areas are still having higher levels of multiple sexual partners.

Knowledge, attitudes, and practices and their policy implications in childhood diarrhoea in Uganda.

A nationwide study of the knowledge, attitudes, and practices about childhood diarrhoea among health workers and mothers of children less than 5-years old was conducted in Uganda during 1987. We found that each child, on the average, has 6 episodes of diarrhoea in a year. While most parents (65%) continue with almost normal feeding practices during their children's diarrhoea, as is officially recommended, there are some foods that are traditionally withheld. The use of oral rehydration therapy in the form of a salt and sugar solution is very limited and needs to be promoted. Herbal treatment for diarrhoea is a widespread practice and needs to be studied further to ascertain its usefulness. Over 55% of mothers recognise poor hygiene as the most important cause of childhood diarrhoea. The general level of sanitation is not satisfactory and needs to be improved to achieve the widespread availability of safe water and adequate means of human waste disposal for all homes. The radio was found to be a potentially effective tool for health education, and the need to provide all health workers with continuing education about diarrhoea management was identified.

PIP: A 1987 nationwide study in Uganda explored knowledge, attitudes, and practices about childhood diarrhea among health workers and mothers of children under 5 years. The study found that children suffer an average of 6 diarrheal episodes/year. While 65% of parents continue almost normal feeding practices during these episodes, some foods are withheld. Oral rehydration therapy (ORT) is employed only on a very limited basis. An herbal treatment is, however, widely used. ORT should be promoted and the effectiveness of the herbal treatment investigated. More than 55% of mothers acknowledge that poor hygiene is the most important cause of childhood diarrhea. Even so, sanitation is generally poor and inadequate. Steps must be taken to increase the supply and availability of safe water as well as the efficiency of human waste disposal. Finally, radio holds potential as an effective tool for health education and all health workers should be given continuing education on the management of diarrhea.

Dynamics of spread of HIV-I infection in a rural district of Uganda.

OBJECTIVE: To define the geographical distribution of HIV infection and the community characteristics associated with HIV prevalence in a rural population of Uganda. DESIGN: Seroprevalence survey and interviews of the population aged 13 years and older in 21 randomly selected clusters. SETTING: Rural population of Rakai district, south west Uganda. SUBJECTS: 1292 adults, of whom 594 men and 698 women gave a blood sample and answered the questionnaire. MAIN OUTCOME MEASURES: HIV status determined by ELISA and western blotting in relation to community characteristics. RESULTS: The weighted seroprevalence of HIV for the district was 12.6% with prevalence by cluster varying from 1.2% to 52.8%. Seroprevalence was highest in main road trading centres (men 26%, women 47%), intermediate in rural trading villages on secondary roads (men 22%, women 29%), and lowest in rural agricultural villages (men 8%, women 9%). For both men and women, multiple regression showed a strong negative association between cluster seroprevalence and the proportion of the population employed in agriculture (beta = -0.677 for men, -0.807 for women). Among women, cluster seroprevalence increased with a higher proportion of the population reporting multiple sex partners (beta = 0.814), external travel (beta = 0.579), and injections (beta = 0.483). CONCLUSIONS: Community characteristics, particularly the proportion of the population in agriculture, are associated with HIV prevalence and can be used for targeting interventions. The seroprevalences of HIV suggest spread of infection from main road trading centres, through intermediate trading villages, to rural agricultural villages.

Knowledge, attitudes and practices concerning AIDS in Ugandans.

A survey of the knowledge, attitudes and practices of 3928 Ugandans concerning AIDS was done in two semi-rural communities in August 1987. Eighty-eight per cent of the respondents knew that AIDS could be acquired from other people and that having multiple sexual partners was high-risk behaviour. There were, however, many incorrect beliefs about HIV transmission, including belief in transmission by insect bites (37%), witchcraft (22%) and casual contact with ill people (21%). AIDS was believed to be curable by 15% of the respondents. As part of the survey, blood was obtained from 3907 (99%) participants; 421 (10.8%) had antibody to HIV-1 by enzyme-linked immunosorbent assay (ELISA) and females were more likely to be infected than males (12.5 versus 8.8%, relative risk 1.42). Factors significantly associated with HIV infection on univariate analysis include multiple sexual partners, sexually transmitted diseases (STDs), injections, and being female. Stratified analysis of a history of STDs in people who were monogamous still showed an association with HIV infection. Information about the AIDS epidemic is reaching the Ugandan population; however, changes in behaviour are slower to follow.

PIP: Knowledge, attitudes, and practices with regard to acquired immunodeficiency syndrome (AIDS) were surveyed among 3928 adults in 2 semi-rural communities of Uganda in 1987. 54% of respondents were female; the average age was 33 years and 57% were married. 203 (5%) were personally acquainted with an AIDS victim and 74% could identify at least 1 clinical symptom of AIDS. 88% correctly identified infected individuals as the major source of disease transmission; however, 37% believed AIDS could be spread by insect bites, 22% thought it could be spread through witchcraft. 22% identified dirty drinking water as a source of AIDS, and 47% thought sharing clothes with an AIDS victim would spread the disease. Ways of avoiding AIDS cited by respondents included avoiding sex with prostitutes (92%), reducing the number of sexual partners (89%), using condoms (41%), using antibiotics (23%), and getting protection from a witchdoctor (11%). 72% indicated they would be ashamed if a family member contracted AIDS, 38% felt AIDS victims deserve their punishment, and 56% favored isolating AIDS patients from the community. As part of the survey, blood samples were obtained from 3907 respondents, 421 (11%) of whom were seropositive for infection with human immunodeficiency virus (HIV). The HIV infection rate was 12.5% among females and 8.8% among males. Multiple sexual partners and a history of sexually transmitted diseases (STDs) were the factors most strongly associated with seropositivity. Although males in this study reported more sexual partners than females, the effect of multiple partners on HIV infection was more pronounced in females. This suggests that male-to-female heterosexual transmission predominates in Uganda.