RESUMO
A 72-year-old woman was referred to our hospital for palliative care. Fifteen years earlier, she had undergone total hysterectomy and radiotherapy for cervical cancer. One year before her referral, she visited a hospital due to a gait disturbance and was diagnosed with lymphangiosarcoma. The level of coagulation factor VIII plasma activity was >201% (normal range: 62-145%) and the immunohistochemical results were positive for factor VIII-related antigen in a tumor specimen. To the best of our knowledge, this is the first report of high coagulation factor VIII plasma activity in a patient with lymphangiosarcoma.
Assuntos
Fator VIII/metabolismo , Linfangiossarcoma/sangue , Linfangiossarcoma/imunologia , Idoso , Evolução Fatal , Feminino , Humanos , Imuno-Histoquímica , Linfangiossarcoma/diagnóstico , Linfangiossarcoma/etiologia , Linfedema/complicações , Coxa da Perna , Neoplasias do Colo do Útero/complicações , Fator de von Willebrand/metabolismoRESUMO
A 65-year-old man with limited disease-small cell lung cancer was treated with concurrent chemoradiotherapy which resulted in a partial response. He further received high-dose chemotherapy with autologous peripheral blood stem cell transplantation. Development of non-small cell carcinoma was, however, suspected at a site of the residual nodule in cytological examination using bronchoscopy. He then underwent lobectomy, which revealed that the nodule was composed of necrotic tissue. He has been alive without recurrence for seven years. This multimodality treatment appeared to be effective for this patient. However, further investigation is necessary to clarify the role of multimodality treatment.
