[Lymphocytic colitis caused by medicine ingredient modification].

A 49-year-old woman was referred to our hospital for further evaluation and treatment of diarrhea. Colonoscopic findings revealed indistinct vascular patterns and extensive edema in a colon segment, and white granular mucosa and crack-like appearance in the sigmoid colon and rectum. She was diagnosed with lymphocytic colitis (LC) based on lymphocytic infiltration into the epithelium on histopathological examination. Diarrhea symptoms resolved after long-term medication withdrawal. This medicine's composition was changed 4 years ago and this modification possibly triggered LC.

[Pulmonary resection in renal cell carcinoma metastasis;the influence of histologic atypia of the metastatic focus on preoperative or perioperative diagnosis].

UNLABELLED: The diagnostic potential of histological atypia grades in distinguishing between primary lung tumors and renal pulmonary metastases. OBJECTIVE: In cases of pulmonary resection for renal cell carcinoma patients, both the preoperative and perioperative diagnosis of lung cancer may be complicated by the need to distinguish between a primary lung tumor and metastatic renal tumor. The degree of histological atypia (grade) of the suspected metastatic focus may indicate the source of the lesion. The aim of this study was to evaluate the preoperative and perioperative diagnostic potential of histological atypia in determining the origin of lung tumors. STUDY DESIGN: Five cases that involved surgery for suspected lung metastasis from renal cell carcinoma were investigated. RESULTS: In cases for which the precise diagnosis of the metastatic focus was uncertain, histological atypia of the metastatic focus was of grade 3, whereas that of the primary renal cancer was of grade 1 or 2. CONCLUSION: These findings suggest that lung metastases with grade 3 histological atypia are suspected to be primary lung tumors on the basis of preoperative imaging, and preoperative distinction between primary lung tumors and metastases from renal cell carcinoma is therefore difficult. In such cases, the choice of operative method needs to be very carefully considered.