[Connection between severity of the course of tick-borne encephalitis with the concentration of interleukin-2 and interleukin-6 in blood]. / Izuchenie sviazi tiazhesti techeniia zabolevaniia s kontsentratsiei interleikina-2 i interleikina-6 v syvorotkakh krovi bol'nykh kleshchevym éntsefalitom.

AIM: To test IL-6 and IL-2 serum concentrations as indirect prognostic indicators in tick-borne encephalitis (TBE) course. MATERIAL AND METHODS: 13 TBE patients' sera were examined for IL-2 and IL-6. RESULTS: IL-6 was not detected in patients with TBE fever but was detected in meningoencephalytic TBE. CONCLUSION: TBE patients demonstrate a positive correlation between the disease severity and serum IL-6. This criterion is proposed as a prognostic factor of a TBE course.

[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein]. / Protektivnaia aktivnsot' bakterial'noi plazmidy, nesushchei gen nestrukturnogo belka NS1 virusa kleshchevogo éntsefalita.

Three intramuscular injections (50 micrograms each) with bacterial plasmid pMV45 carrying nonstructural gene of NS1 protein of tick-borne encephalitis (TBE) virus protected 88% Balb/c mice from lethal challenge with the virus. Antibodies to NS1 nonstructural protein were detected in the sera of vaccinated mice after the challenge. Absence of antibodies to E structural protein indicated absence of manifest infectious process in mice vaccinated with plasmid and challenged with a lethal dose of TBE virus.