RESUMO
The effect of two anthelmintics--biltricide and chloxyl--on the immune status has been compared in patients with chronic opisthorchiasis. It has been established that in using chloxyl there is a more marked and persistent imbalance of immunoregulatory T-lymphocyte subpopulations (T mu-helpers-inducers and T gamma-suppressors-effectors).
Assuntos
Anti-Helmínticos/uso terapêutico , Opistorquíase/tratamento farmacológico , Praziquantel/uso terapêutico , Xilenos/uso terapêutico , Formação de Anticorpos/efeitos dos fármacos , Formação de Anticorpos/imunologia , Doença Crônica , Humanos , Imunidade Celular/efeitos dos fármacos , Imunidade Celular/imunologia , Imunoglobulinas/análise , Contagem de Leucócitos/efeitos dos fármacos , Opistorquíase/imunologia , Fatores de TempoRESUMO
The comparative study of disturbances in the immune status of patients with different clinical forms of tick-borne encephalitis has revealed that in the severe (meningeal) form of the disease more pronounced imbalance in the immune system develops, especially with respect to immunoregulatory subpopulations of T-lymphocytes. This seems to be the cause of delayed activation of immune processes in this group of patients in comparison to those having an aborted course of the disease.
Assuntos
Linfócitos B/imunologia , Encefalite Transmitida por Carrapatos/imunologia , Linfócitos T/imunologia , Adolescente , Adulto , Idoso , Convalescença , Feminino , Humanos , Imunidade Celular/imunologia , Masculino , Pessoa de Meia-Idade , Kit de Reagentes para Diagnóstico , Formação de Roseta , Linfócitos T Auxiliares-Indutores/imunologia , Linfócitos T Reguladores/imunologia , Fatores de TempoRESUMO
Most immunological characteristics became practically normal 7-9 months after a single chloxyl treatment course in patients with chronic cholecystocholangitic opisthorchiasis. The patients who required repeated chemotherapy showed more profound and steady immune disturbances.
Assuntos
Antiplatelmínticos/uso terapêutico , Opistorquíase/imunologia , Xilenos/uso terapêutico , Adolescente , Adulto , Formação de Anticorpos/efeitos dos fármacos , Formação de Anticorpos/imunologia , Doença Crônica , Feminino , Humanos , Imunidade Celular/efeitos dos fármacos , Imunidade Celular/imunologia , Masculino , Pessoa de Meia-Idade , Opistorquíase/tratamento farmacológico , Fatores de TempoRESUMO
Analysis of the structure of immunoregulatory cells (IRC) as the reflection of cell interaction in healthy persons and in patients with typhoid fever, tick-borne encephalitis, or chronic opisthorchiasis has shown that the characteristics under study (information entropy, structural information, the coefficient of ecological-genetic correspondence) are highly sensitive and specific, which makes it possible to use them quite effectively for differentiating health from disease and for identifying this disease. The study of IRC structure as the reflection of cell interrelations helps evaluate the changes in the organization of IRC system as a whole in different infectious diseases.