1.
Eksp Klin Farmakol
; 56(1): 22-4, 1993.
Artigo
em Russo
| MEDLINE
| ID: mdl-8100727
RESUMO
The effects of some antiallergic drugs on H1-histamine, 5-HT2-serotonin, and M-cholinoreceptors ligand binding in the rat brain were studied in vitro. Dimedrol, dimebon, and phencarol bonded to H1-receptors: IC50 were 76 +/- 10, 153 +/- 15, 320 +/- 60 nM, respectively. Diazoline and dimebon had some affinity for 5-HT2-receptors, its IC50 was 880 +/- 90 nM. Dimedrol, phencarol and diazoline were found to be active against M-cholinoceptors, but when given in the maximal concentration (10 microM) it acted nonspecifically. In contrast to the other drugs, bicarphen had no effects on the binding of [3H]-mepyramine, [3H]-ketanserine, and [3H]-quinuclidinyl benzylate in the rat brain.
Assuntos
Encéfalo/efeitos dos fármacos , Antagonistas dos Receptores Histamínicos H1/farmacologia , Antagonistas dos Receptores H2 da Histamina/farmacologia , Ketanserina/farmacocinética , Pirilamina/farmacocinética , Quinuclidinil Benzilato/farmacocinética , Animais , Encéfalo/metabolismo , Interações Medicamentosas , Ligantes , Masculino , Ratos , Ratos Sprague-Dawley , Receptores Histamínicos H1/efeitos dos fármacos , Receptores Histamínicos H1/metabolismo , Receptores Histamínicos H2/efeitos dos fármacos , Receptores Histamínicos H2/metabolismo , Receptores Muscarínicos/efeitos dos fármacos , Receptores Muscarínicos/metabolismo , Trítio
2.
Biull Eksp Biol Med
; 72(12): 81-3, 1971 Dec.
Artigo
em Russo
| MEDLINE
| ID: mdl-5132143