1.
Biochem Soc Trans
; 31(Pt 1): 56-9, 2003 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12546653
RESUMO
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.